全文获取类型
收费全文 | 10073篇 |
免费 | 723篇 |
国内免费 | 53篇 |
专业分类
耳鼻咽喉 | 91篇 |
儿科学 | 322篇 |
妇产科学 | 221篇 |
基础医学 | 1611篇 |
口腔科学 | 140篇 |
临床医学 | 882篇 |
内科学 | 2026篇 |
皮肤病学 | 228篇 |
神经病学 | 907篇 |
特种医学 | 413篇 |
外国民族医学 | 2篇 |
外科学 | 1582篇 |
综合类 | 133篇 |
一般理论 | 3篇 |
预防医学 | 905篇 |
眼科学 | 138篇 |
药学 | 563篇 |
中国医学 | 43篇 |
肿瘤学 | 639篇 |
出版年
2023年 | 44篇 |
2022年 | 79篇 |
2021年 | 182篇 |
2020年 | 114篇 |
2019年 | 166篇 |
2018年 | 202篇 |
2017年 | 157篇 |
2016年 | 174篇 |
2015年 | 214篇 |
2014年 | 264篇 |
2013年 | 372篇 |
2012年 | 604篇 |
2011年 | 609篇 |
2010年 | 374篇 |
2009年 | 374篇 |
2008年 | 583篇 |
2007年 | 600篇 |
2006年 | 601篇 |
2005年 | 570篇 |
2004年 | 562篇 |
2003年 | 494篇 |
2002年 | 487篇 |
2001年 | 242篇 |
2000年 | 222篇 |
1999年 | 190篇 |
1998年 | 148篇 |
1997年 | 132篇 |
1996年 | 111篇 |
1995年 | 117篇 |
1994年 | 95篇 |
1993年 | 99篇 |
1992年 | 95篇 |
1991年 | 98篇 |
1990年 | 108篇 |
1989年 | 106篇 |
1988年 | 83篇 |
1987年 | 88篇 |
1986年 | 87篇 |
1985年 | 100篇 |
1984年 | 69篇 |
1983年 | 73篇 |
1982年 | 51篇 |
1981年 | 56篇 |
1980年 | 45篇 |
1979年 | 55篇 |
1978年 | 44篇 |
1977年 | 39篇 |
1975年 | 35篇 |
1974年 | 46篇 |
1973年 | 40篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Cromb Amandine Le Loarer Franois Sitbon Maxime Italiano Antoine Stoeckle Eberhard Buy Xavier Kind Michle 《European radiology》2020,30(5):2413-2424
European Radiology - The strongest adverse prognostic factor in myxoid/round cell liposarcomas (MRC-LPS) is the presence of a round cell component above 5% within the tumor bulk. Its identification... 相似文献
2.
3.
4.
5.
6.
7.
Dominique Trudel Luminita-Mihaela Avarvarei Michèle Orain Stéphane Turcotte Marie Plante Jean Grégoire Reinhild Kappelhoff David P. Labbé Dimcho Bachvarov Bernard Têtu Christopher M. Overall Isabelle Bairati 《Pathology, research and practice》2019,215(6):152369
Ovarian carcinoma is one of the most lethal malignancies, but only very few prognostic biomarkers are known. The degradome, comprising proteases, protease non-proteolytic homologues and inhibitors, have been involved in the prognosis of many cancer types, including ovarian carcinoma. The prognostic significance of the whole degradome family has not been specifically studied in high-grade serous ovarian cancer. A targeted DNA microarray known as the CLIP-CHIP microarray was used to identify potential prognostic factors in ten high-grade serous ovarian cancer women who had early recurrence (<1.6 years) or late/no recurrence after first line surgery and chemotherapy. In women with early recurrence, we identified seven upregulated genes (TMPRSS4, MASP1/3, SPC18, PSMB1, IGFBP2, CFI – encoding Complement Factor I – and MMP9) and one down-regulated gene (ADAM-10). Using immunohistochemistry, we evaluated the prognostic effect of these 8 candidate genes in an independent cohort of 112 high-grade serous ovarian cancer women. Outcomes were progression, defined according to CA-125 criteria, and death. Multivariate Cox proportional hazard regression models were done to estimate the associations between each protein and each outcome. High ADAM-10 expression (intensity of 2–3) was associated with a lower risk of progression (adjusted hazard ratio (HR): 0.51; 95% confidence interval (CI): 0.29-0.87). High complement factor I expression (intensity 2–3) was associated with a higher risk of progression (adjusted HR: 2.30, 95% CI: 1.17–4.53) and death (adjusted HR: 3.42; 95% CI: 1.72–6.79). Overall, we identified the prognostic value of two proteases, ADAM-10 and complement factor I, for high-grade serous ovarian cancer which could have clinical significance. 相似文献
8.
Fran ois X. Roux M.D. Serge Mordon Ph.D. Catherine Fallet-Bianco M.D. Louis Merienne M.D. Bertrand C. Devaux M.D. Jean-Paul Chodkiewicz M.D. 《Surgical neurology》1990,34(6):402-407
Considering that the 1.32-μm Nd-YAG laser should have physicothermal properties close to those of the CO2 laser, a series of experiments were conducted on rat cortex (N = 51). Three laser wavelengths were compared: CO2 laser (10.6 μm), 1.06-μm Nd-YAG, and 1.32-μm Nd-YAG lasers. For each shot, temperature measurements were recorded with an infrared thermographic videocamera. The digitized signals were figured as thermal profiles and temperature developments. Ninety-five shots were correctly studied and analyzed: CO2, N = 29; 1.06-μm Nd-YAG, N = 20; 1.32-μm Nd-YAG, N = 46. The histological lesions produced by these three lasers were compared on animals killed 24 hours (N = 20), 8 days (N = 20), and 30 days (N = 5) after the laser impacts. For equivalent densities of energy, the depth of cortical necrosis was comparable for the CO2 laser (200–250 μm) and the 1.32-μm Nd-YAG laser (210–260μm) whatever the date of death; the 1.06-μm Nd-YAG laser shots were responsible for much more important damage (400–550μm). Because of its important absorption in water and nervous tissue, the authors consider the 1.32-μm Nd-YAG laser most suitable for neurosurgery, particularly because it is conducted through optic fibers, and therefore is easy to handle during neurosurgical procedures. 相似文献
9.
10.
Peter D. Le Roux David S. Jardine Paul M. Kanev John D. Loeser 《Child's nervous system》1991,7(1):34-39
We reviewed the results of all pediatric patients undergoing intracranial pressure (ICP) monitoring in a 2-year period at our institution. The outcome of patients suffering hypoxia or ischemic injuries (HII) is compared to those suffering non-hypoxic or non-ischemic injuries (NHII). Thirty-four patients had ICP monitors placed during the study period. Inconplete patient information led to the exclusion of 5 patients. An additional 5 patients were excluded because no measures to control ICP were taken after the monitor was placed. Twenty-four patients required treatment for raised ICP (hyperventilation, 24; mannitol, 19; barbiturate coma, 6). Admission Glasgow Coma Score in patients suffering HII (median score 5) and NHII (median score 6) were not significantly different (Mann-Whitney U Test). Only 2 of 8 patients with HII were near-drowning vietims. The remaining 6 had HII from other causes (5 survivors of various forms of asphyxia and 1 of cardiac arrest). All 8 patients had poor outcomes (1 severely disabled; 7 died). The 16 patients with NHII had a variety of diagnoses (6 trauma, 5 encephalitis, 4 bacterial meningitis, 1 diabetic ketoacidosis). Among these, 6 had good outcomes and 10 poor outcomes (2 severely disabled, 2 vegetative, and 6 died). The difference in outcome between patients with NHII and HII is significant at P=0.059 (Fischer Exact test). Patients with NHII may benefit from ICP monitoring. Patients with HII from near-drowning and other causes did not appear to benefit from ICP monitoring and interventions directed at controlling ICP. 相似文献