全文获取类型
收费全文 | 620篇 |
免费 | 81篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 2篇 |
妇产科学 | 2篇 |
基础医学 | 45篇 |
口腔科学 | 7篇 |
临床医学 | 65篇 |
内科学 | 72篇 |
皮肤病学 | 3篇 |
神经病学 | 34篇 |
特种医学 | 17篇 |
外科学 | 65篇 |
综合类 | 121篇 |
预防医学 | 52篇 |
眼科学 | 1篇 |
药学 | 94篇 |
3篇 | |
中国医学 | 44篇 |
肿瘤学 | 92篇 |
出版年
2024年 | 6篇 |
2023年 | 30篇 |
2022年 | 78篇 |
2021年 | 81篇 |
2020年 | 49篇 |
2019年 | 37篇 |
2018年 | 38篇 |
2017年 | 20篇 |
2016年 | 18篇 |
2015年 | 31篇 |
2014年 | 29篇 |
2013年 | 29篇 |
2012年 | 32篇 |
2011年 | 32篇 |
2010年 | 32篇 |
2009年 | 52篇 |
2008年 | 21篇 |
2007年 | 11篇 |
2006年 | 16篇 |
2005年 | 4篇 |
2004年 | 11篇 |
2003年 | 4篇 |
2002年 | 9篇 |
2001年 | 13篇 |
2000年 | 3篇 |
1999年 | 8篇 |
1998年 | 2篇 |
1997年 | 6篇 |
1996年 | 4篇 |
1995年 | 4篇 |
1994年 | 2篇 |
1992年 | 2篇 |
1991年 | 3篇 |
1989年 | 1篇 |
1988年 | 1篇 |
排序方式: 共有719条查询结果,搜索用时 15 毫秒
1.
2.
3.
目的描述12~36月龄幼儿胃肠道功能情况,探讨潜在影响因素。方法2018年9月—2019年1月在北京市朝阳区某社区卫生服务中心招募12~36月龄幼儿385名,收集幼儿及母亲基本信息,采用简版《婴幼儿胃肠道症状问卷》评估幼儿胃肠道功能。问卷共10个问题,反映幼儿胃肠道症状(6个问题)和相关行为(4个问题)。胃肠道功能总评分为10~60分,其中胃肠道症状6~36分、胃肠道相关行为4~24分,评分越高提示胃肠功能越弱;将总评分等于或高于第二个三分位数(17分)定义为轻度胃肠不适。采用多因素logistic回归分析幼儿轻度胃肠不适的可能影响因素。结果幼儿胃肠道功能总评分、症状评分和相关行为评分的中位数(四分位数间距)分别为13.0(11.0~19.0)分、6.0(6.0~10.0)分和6.0(5.0~8.0)分。小月龄(12~17月龄14.5分,18~23月龄13.0分)比大月龄(24~29月龄12.0分,30~36月龄12.5分)、母亲为初产妇(14.0分)比经产妇(12.0分)的幼儿中位胃肠道功能总评分高(P<0.05)。轻度胃肠不适幼儿124名(32.2%),母亲为初产妇(36.8%)比母亲为经产妇(21.8%)的幼儿轻度胃肠不适发生率显著升高(P=0.004)。多因素logistic回归分析显示,12~17月龄幼儿与30~36月龄幼儿相比(调整OR,2.32;95%CI,1.14~4.71)、母亲为初产妇的幼儿与经产妇的幼儿相比(调整OR,2.05;95%CI,1.19~3.52),轻度胃肠不适风险显著升高。幼儿性别、分娩方式、母乳喂养时长和母亲分娩年龄对轻度胃肠不适发生风险无显著影响。结论幼儿胃肠道功能整体较好,幼儿月龄及母亲产次影响幼儿胃肠功能,小月龄及母亲为初产妇的幼儿易发生轻度胃肠不适。 相似文献
4.
Bai Shilei Yang Pinghua Xie Zhihao Li Jun Lei Zhengqing Xia Yong Qian Guojun Zhang Baohua Pawlik Timothy M. Lau Wan Yee Shen Feng 《Annals of surgical oncology》2021,28(13):8174-8185
Annals of Surgical Oncology - The aim of this study was to examine prognostic differences between liver resection (LR) and percutaneous radiofrequency ablation (PRFA) for hepatocellular carcinoma... 相似文献
5.
Yapu Cao Kaixiang He Qingqing Li Xin Chen Haiying Mo Zhihao Li Qiaolin Ji Ganpeng Li Gang Du Haiying Yang 《Journal of basic microbiology》2023,63(1):17-25
Gastrodia elata is an achlorophyllous and fully mycoheterotrophic orchid which obtains carbon and other nutrients from Armillaria species in its life cycle. Many researchers suggested that plant hormones, as signing molecules, play a central role in the plant–fungi interaction. In the process of Armillaria gallica 012 m cultivation, both exogenous indole-3-acetic acid (IAA) and indole-3-butyric acid (IBA) distinctly stimulated the growth of mycelia in solid media. The differential expression genes (DEGs) of A. gallica 012 m with IAA versus blank control (BK) and IBA versus BK were investigated. The results showed that more than 80% of DEGs of the IAA group were coincident with the DEGs of the IBA group, and more than half of upregulated DEGs and most of the downregulated DEGs of the IAA group coincided with those DEGs of the IBA group. Above research implied that A. gallica 012 m could perceive IAA and IBA, and possess similar responses and signaling pathways to IAA and IBA. The overlapping differential genes of the IAA group and IBA group were analyzed by GO term, and the results showed that several DEGs identified were related to biological processes including positive regulation of the biological process and biological process. The downregulated NmrA-like and FKBP_C genes might be benefit to the growth of mycelia. Those results can explain that exiguous IAA and IBA improved the growth of A. gallica to some extent. We speculate that IAA and IBA are signaling molecules, and regulate the expression of growth-related genes of A. gallica 012 m by the same signaling pathway. 相似文献
6.
沙漠干热环境徒手应激行军对人体热休克蛋白27的影响 总被引:4,自引:0,他引:4
为探讨沙漠干热徒手应激行军人体内热休克蛋白27(HSP27)的变化规律,对在沙漠干热环境中以不同速度和时间徒手行军的59名战士和14名对照组的HSP27进行了研究。结果发现,不论是以3.5还是5.0km/h徒手应激行军,各不同行军时间组HSP27明显增高(P<0.01),相同行军时间不同行军速度组和同速度不同时间组之间的HSP27均无显著性差异(P>0.05)。随行军速度(应激强度)增加,同一行军时间者血浆HSP27均略增高,行军小时1小时HSP27最高,之后略下降,2小时后变化不大,行军3小时与行军2小时基本处于同一水平。 相似文献
7.
Chaojun Xue Changyuan Wang Qi Liu Qiang Meng Huijun Sun Xiaokui Huo Xiaodong Ma Zhihao Liu Xiaochi Ma Jinyong Peng Kexin Liu 《Tumour biology》2016,37(7):8587-8597
P-glycoprotein (P-gp) is one of the major obstacles to efficiency of cancer chemotherapy. Here, we investigated whether combination of metformin and 2-deoxyglucose reverses the multidrug resistance (MDR) of K562/Dox cells and tried to elucidate the possible mechanisms. The combination of metformin and 2-deoxyglucose selectively enhanced the cytotoxicity of doxorubicin against K562/Dox cells. Metformin was not a substrate of P-gp but suppressed the elevated level of P-gp in K562/Dox cells. The downregulation of P-gp may be partly attributed to the inhibition of extracellular signal-regulated kinase pathway. The addition of 2-deoxyglucose to metformin initiated a strong metabolic stress in both K562 and K562/Dox cells. Combination of metformin and 2-deoxyglucose inhibited glucose uptake and lactate production in K562 and K562/Dox cells leading to a severe depletion in ATP and a enhanced autophagy. Above all, P-gp substrate selectively aggravated this ATP depletion effect and increased cell apoptosis in K562/Dox cells. In conclusion, metformin decreases P-gp expression in K562/Dox cells via blocking phosphorylation of extracellular signal-regulated kinase. P-gp substrate increases K562/Dox cell apoptosis via aggravating ATP depletion induced by combination of metformin and 2-deoxyglucose. Our observations highlight the importance of combination of metformin and 2-deoxyglucose in reversing multidrug resistance. 相似文献
8.
Yong Tao Byunghak Kang Daniel A. Petkovich Yuba R. Bhandari Julie In Genevieve Stein-OBrien Xiangqian Kong Wenbing Xie Nicholas Zachos Shinji Maegawa Himani Vaidya Stephen Brown Ray-Whay Chiu Yen Xiaojian Shao Jai Thakor Zhihao Lu Yi Cai Yuezheng Zhang Hariharan Easwaran 《Cancer cell》2019,35(2):315-328.e6
9.
10.
目的探讨负压封闭引流技术(VSD)在治疗骨创伤创面软组织损伤中的临床疗效。方法将80例骨创伤创面软组织损伤患者按照抽签方法随机分为对照组与观察组各40例。对照组予常规换药治疗,观察组行负压封闭引流技术(VSD)治疗。比较两组治疗效果。结果观察组患者10 d内换药率为100%,明显高于对照组(P<0.01);对照组Ⅱ期手术处理时间、治疗后创面面积、换药次数、应用抗生素费用、住院时间以及植皮优良率分别为(14.59±3.29)d、(14.11±1.78)cm2、(9.34±1.28)次、(2 102±125)元、(29.43±1.57)d及70.00%,观察组分别为(9.02±1.38)d、(10.22±1.54)cm2、(1.78±0.36)次、(1 688±101)元、(16.27±0.89)d及90.00%,两组相比,差异具有统计学意义(P<0.05)。结论负压封闭引流技术(VSD)应用于骨创伤创面软组织损伤的临床治疗之中效果明显,值得推广和应用。 相似文献