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Ali Asghar Ghafarizadeh Mahdi Malmir Samira Naderi Noreini Tayebeh Faraji Zeynab Ebrahimi 《Andrologia》2021,53(1):e13891
Induction of oxidative stress during the sperm preparation process for assisted reproductive techniques (ART) in men can weaken sperm parameters. Vitamin E (VE) is considered a factor in boosting male fertility. This experimental study (in vitro) aimed to assess the impact of VE supplementation on sperm quality and lipid peroxidation during sperm sampling at different times. For this mention, semen samples were collected from 50 asthenoteratozoospermic men. Samples were divided into control and test groups for 2, 4 and 6 hr that the test group was incubated with VE (2 mM). In two groups, total motility, progressive motility and viability based on the WHO 2010 criteria were assessed. Moreover, malondialdehyde (MDA) levels were evaluated in each group. In the control group, total and progressive motility and sperm viability were decreased significantly after 2 hr; however, MDA levels were increased significantly after 6 hr. Also, in the test group, sperm parameters were increased significantly after 2 hr, and MDA levels were decreased significantly after 6 hr compared to the control group. In outcome, in vitro VE supplementation may protect spermatozoa from the adverse effect of oxidative stress during sperm preparation via preservation antioxidant processes in normal condition. 相似文献
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Zeynab Shaghaghi Mortaza Bonyadi Mohammad H. Somi Manouchehr Khoshbaten 《Saudi Journal Of Gastroenterology》2014,20(1):54-58
Background/Aim:
Previous studies have shown the association of some genetic factors, such as Plasminogen activator inhibitor type-1 (PAI-1) 4G/5G polymorphism, with the development of inflammatory bowel disease (IBD). We aimed to study this polymorphism as a risk factor in IBD patients in this cohort.Patients and Methods:
One hundred and fifteen IBD patients and 95 healthy controls were selected from Iranian Azeri Turks and -6754G/5G polymorphism of PAI-1 gene was tested by polymerase chain reaction using allele-specific primers confirmed by sequencing.Results:
There was no significant difference of PAI-1 polymorphism between IBD patients and the control group (P > 0.05). Furthermore, these data showed no significant difference between Crohn''s disease and ulcerative colitis patients. However, 4G/4G homozygotes have reduced probability to progression of loss of appetite, whereas 5G/5G genotypes have increased risk for development of chronic diarrhea without blood, nausea, and loss of appetite.Conclusions:
Although our study showed no significant association of PAI-1 polymorphism between patients and control group, the carriers of 4G/4G genotype and 4G allele had reduced risk for the progression of IBD features in this cohort. 相似文献4.
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Malek Kammoun Jerome Piquereau Lydie Nadal‐Desbarats Sandra Même Maud Beuvin Gisle Bonne Vladimir Veksler Yann Le Fur Philippe Pouletaut William Même Frederic Szeremeta Jean‐Marc Constans Elizabeth S. Bruinsma Molly H. Nelson Holte Zeynab Najafova Steven A. Johnsen Malayannan Subramaniam John R. Hawse Sabine F. Bensamoun 《Acta physiologica (Oxford, England)》2020,228(3)
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Masoud Alirezaei Omid Dezfoulian Ali Sookhtehzari Peyman Asadian Zeynab Khoshdel 《Comparative clinical pathology》2014,23(5):1359-1365
Purified oleuropein from olive leaf extract indicated antioxidant properties in our previous reports. The recent study demonstrated that the lesions of absolute ethanol could be attributed to the increasing reactive oxygen species, subsequently lipid peroxidation and gastric ulcers. Therefore, the antioxidant effects of oleuropein as a natural antioxidant agent on intestine mucosal damages induced by absolute ethanol were investigated in the present study. The 42 adult male rats were divided into four (control, oleuropein, ethanol, and oleuropein plus ethanol) groups. Oleuropein at a dosage of 12 mg/kg was used for 10 consecutive days in oleuropein and oleuropein plus ethanol groups, thereafter absolute ethanol (once, 1 ml/rat) was administrated orally in ethanol and oleuropein plus ethanol groups at fasting state by gavage. The duodena of rats were removed for histopathology and antioxidant assay. Histological evidence of severe mucosal damages were confirmed by histopathology findings in ethanol group and prevented in oleuropein plus ethanol group. In this setting, glutathione peroxidase and catalase activities were significantly higher in oleuropein and oleuropein plus ethanol groups than the ethanol-treated rats. In contrast, thiobarbituric acid reactive substances concentration (as a lipid peroxidation marker) significantly increased in ethanol-treated rats when compared to the other groups. Our results suggest that olive leaf extract (containing oleuropein) exerts a potent antioxidant agent against oxidative stress. These findings allow us to exploit the advantages of oleuropein treatment in various diseases induced by oxidative stress in humans. 相似文献
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Mohammad Hossein Baradaranfar Zeynab Sadat Ahmadi Mohammad Hossein Dadgarnia Mohammad Hossein Bemanian Saeid Atighechi Ghasem Karimi Abolhasan Halvani Nasim Behniafard Amin Baradaranfar Tohid Emami Meybodi 《European archives of oto-rhino-laryngology》2014,271(2):311-316
Chronic rhinosinusitis is a common inflammatory condition in western countries. Nasal polyposis has different symptoms such as nasal obstruction, anterior or posterior nasal drip, reduced sense of smell, and facial pain. Medical and endoscopic treatments are the two main treatments for nasal polyposis. Our aim was to compare the efficacy of different methods on olfactory function. This is a non-randomized clinical trial study that was done on 60 patients who were divided into two groups (medical and surgical). Patients were matched based on age, history of smoking, and the severity of obstruction. The radiologist score of Lund-Mackay staging system was used to match patients in two arms of the trial based on the severity of nasal obstruction. Patients in surgery groups underwent functional endoscopic sinus surgery under general anesthesia and then received Fluticasone propionate nasal spray for 8 weeks (400 mcg bd). Patients in the medical group were only prescribed with Fluticasone propionate with the same duration and same dose as mentioned. As a result of treatment protocol, both medical and surgical group experienced improvement in olfactory function but statistical analyses revealed that surgery resulted in better resolution of symptoms. Our observation revealed that combined treatment had a better effect than medical treatment in restoring olfaction in patients with nasal polyposis. 相似文献
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Reza Rostami Payman Salamati Kourosh Karimi Yarandi Alireza Khoshnevisan Soheil Saadat Zeynab Sadat Kamali Somaie Ghiasi Atefeh Zaryabi Seyed Shahab Ghazi Mir Saei Mehdi Arjipour Mohammad Saeid Rezaee-Zavareh Vafa Rahimi-Movaghar 《中华创伤杂志(英文版)》2017,20(5):278-282
Purpose: There are some studies which showed neurofeedback therapy (NFT) can be effective in clients
with traumatic brain injury (TBI) history. However, randomized controlled clinical trials are still needed
for evaluation of this treatment as a standard option. This preliminary study was aimed to evaluate the
effect of NFT on continuous attention (CA) and short-term memory (STM) of clients with moderate TBI
using a randomized controlled clinical trial (RCT).
Methods: In this preliminary RCT, seventeen eligible patients with moderate TBI were randomly allocated in two intervention and control groups. All the patients were evaluated for CA and STM using the
visual continuous attention test and Wechsler memory scale-4th edition (WMS-IV) test, respectively,
both at the time of inclusion to the project and four weeks later. The intervention group participated in
20 sessions of NFT through the first four weeks. Conversely, the control group participated in the same
NF sessions from the fifth week to eighth week of the project.
Results: Eight subjects in the intervention group and five subjects in the control group completed the
study. The mean and standard deviation of participants'' age were (26.75 ± 15.16) years and (27.60 ± 8.17)
years in experiment and control groups, respectively. All of the subjects were male. No significant
improvement was observed in any variables of the visual continuous attention test and WMS-IV test between two groups (p≥0.05).
Conclusion: Based on our literature review, it seems that our study is the only study performed on the effect of NFT on TBI patients with control group. NFT has no effect on CA and STM in patients with moderate TBI. More RCTs with large sample sizes, more sessions of treatment, longer time of follow-up and different protocols are recommended. 相似文献