全文获取类型
收费全文 | 766篇 |
免费 | 62篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 26篇 |
儿科学 | 6篇 |
妇产科学 | 21篇 |
基础医学 | 49篇 |
口腔科学 | 54篇 |
临床医学 | 63篇 |
内科学 | 174篇 |
皮肤病学 | 13篇 |
神经病学 | 46篇 |
特种医学 | 45篇 |
外科学 | 147篇 |
综合类 | 11篇 |
一般理论 | 1篇 |
预防医学 | 38篇 |
眼科学 | 26篇 |
药学 | 62篇 |
中国医学 | 1篇 |
肿瘤学 | 51篇 |
出版年
2024年 | 1篇 |
2023年 | 6篇 |
2022年 | 32篇 |
2021年 | 52篇 |
2020年 | 28篇 |
2019年 | 35篇 |
2018年 | 46篇 |
2017年 | 34篇 |
2016年 | 41篇 |
2015年 | 25篇 |
2014年 | 49篇 |
2013年 | 43篇 |
2012年 | 75篇 |
2011年 | 70篇 |
2010年 | 43篇 |
2009年 | 27篇 |
2008年 | 35篇 |
2007年 | 29篇 |
2006年 | 23篇 |
2005年 | 30篇 |
2004年 | 30篇 |
2003年 | 15篇 |
2002年 | 10篇 |
2001年 | 6篇 |
2000年 | 3篇 |
1999年 | 7篇 |
1998年 | 2篇 |
1997年 | 1篇 |
1996年 | 5篇 |
1995年 | 1篇 |
1994年 | 5篇 |
1992年 | 5篇 |
1990年 | 3篇 |
1989年 | 3篇 |
1988年 | 3篇 |
1987年 | 3篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1971年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有834条查询结果,搜索用时 15 毫秒
1.
2.
A. Moutabarrik B. Ramdani B.G. Benghanem K. Hachim D. Zaid I. Nakanishi S. Takahara M. Ishibashi 《Transplant international》1994,7(S1):536-538
Abstract Kidney cells are an important source of immunoregulatory molecules that regulate cell-to-cell interactions, which is the key step in the generation of the immunoresponse to alloantigens. In this study we identified the cytokines that are produced by both lymphoid cells and kidney cells when coincubated in mixed kidney lymphocyte cultures (MKLC). The capacity of kidney cells to stimulate the proliferation of effector allogeneic lymphocytes was assayed by incubating irradiated kidney cells and lymphocyte. The cytokine secretion profile in MKLC was investigated by incubating monolayers of kidney cells with effector peripheral blood mononuclear cells (PBMC). The culture supernatants were harvested on days 1, 2, 3, 4, 5, 6, 7, and 8 and assayed for IL-1β, IL-2, IL-6, and TNF alpha using an ELISA. Kidney cells, in comparison to PBMC stimulator cells were poor stimulators of the allo-proliferation even when HLA expression was increased by IFN gamma treatment. Compared to lymphocyte or kidney cells incubated alone, MKLC induced a considerable stimulation of cytokine production. This increase in cytokine production was observed essentially for IL-2 and IL-6 (at day 3, a 10-fold increase in IL-2 and a 5-fold increase in IL-6). This study provided evidence that target kidney cells and effector lymphocyte interactions generate a number of cytokines such as IL-11, IL-2, IL-6, or TNF alpha. These cytokines are known to modulate alloproliferation and generation of cytotoxic J lymphocytes (CTL). 相似文献
3.
P G Baraldi B Cacciari A Guiotto R Romagnoli A N Zaid G Spalluto 《Il Farmaco; edizione pratica》1999,54(1-2):15-25
DNA minor-groove binding drugs have been extensively studied in the last years in order to influence the regulation of gene expression in neoplastic disorders by means of specific interactions with DNA bases. Pyrrolo[2,1-c][1,4]benzodiazepines (PBDs), CC-1065 and distamycins are three classes of minor-groove alkylating agents which showed interesting cytotoxicity profiles, but they cannot be used in humans for various toxicity problems. For this reason many groups applied heterocyclic substitutions extensively, in order to either modify the reactivity profile or introduce extra interactions within the minor groove, thus changing the binding site or modulating the binding sequence. 相似文献
4.
Nadia El Kadmiri Nabil Zaid Ahmed Hachem Younes Zaid Marie-Pierre Dubé Khalil Hamzi Bouchra El Moutawakil Ilham Slassi Sellama Nadifi 《Journal of molecular neuroscience : MN》2014,53(2):189-195
In Morocco, Alzheimer's disease (AD) affects almost 30,000 individuals, and this number could increase to 75,000 by 2020. To our knowledge, the genes predisposing individuals to AD and predicting disease incidence remain elusive. In this study, we aimed to evaluate the genetic contribution of mutations in the amyloid precursor protein (APP) gene exons 16 and 17 to familial and sporadic AD cases. Seventeen sporadic cases and eight family cases were seen at the memory clinic of the University of Casablanca Neurology Department. These patients underwent standard somatic neurological examination, cognitive function assessment, brain imaging, and laboratory tests. Direct sequencing of exons 16 and 17 of the APP gene was performed on genomic DNA of AD patients. In this original Moroccan study, we identified seven novel frameshift mutations in exons 16 and 17 of the APP gene. Interestingly, only one novel splice mutation was detected in a family case. There is a strong correlation between clinical symptoms and genetic factors in Moroccan patients with a family history of AD. Therefore, mutations in APP gene exons 16 and 17 may eventually become genetic markers for AD predisposition. 相似文献
5.
6.
Ritesh K. Srivastava Samer Zaid Kaylani Nayf Edrees Changzhao Li Sarang S. Talwelkar Jianmin Xu Komaraiah Palle Joseph G. Pressey Mohammad Athar 《Oncotarget》2014,5(23):12151-12165
Rhabdomyosarcoma (RMS) typically arises from skeletal muscle. Currently, RMS in patients with recurrent and metastatic disease have no successful treatment. The molecular pathogenesis of RMS varies based on cancer sub-types. Some embryonal RMS but not other sub-types are driven by sonic hedgehog (Shh) signaling pathway. However, Shh pathway inhibitors particularly smoothened inhibitors are not highly effective in animals. Here, we show that Shh pathway effectors GLI1 and/or GLI2 are over-expressed in the majority of RMS cells and that GANT-61, a specific GLI1/2 inhibitor dampens the proliferation of both embryonal and alveolar RMS cells-derived xenograft tumors thereby blocking their growth. As compared to vehicle-treated control, about 50% tumor growth inhibition occurs in mice receiving GANT-61 treatment. The proliferation inhibition was associated with slowing of cell cycle progression which was mediated by the reduced expression of cyclins D1/2/3 & E and the concomitant induction of p21. GANT-61 not only reduced expression of GLI1/2 in these RMS but also significantly diminished AKT/mTOR signaling. The therapeutic action of GANT-61 was significantly augmented when combined with chemotherapeutic agents employed for RMS therapy such as temsirolimus or vincristine. Finally, reduced expression of proteins driving epithelial mesenchymal transition (EMT) characterized the residual tumors. 相似文献
7.
8.
Neil G. Simon MBBS Martin R. Turner PhD Steve Vucic PhD Ammar Al‐Chalabi PhD Jeremy Shefner MD PhD Catherine Lomen‐Hoerth MD PhD Matthew C. Kiernan DSc 《Annals of neurology》2014,76(5):643-657
Amyotrophic lateral sclerosis (ALS) exhibits characteristic variability of onset and rate of disease progression, with inherent clinical heterogeneity making disease quantitation difficult. Recent advances in understanding pathogenic mechanisms linked to the development of ALS impose an increasing need to develop strategies to predict and more objectively measure disease progression. This review explores phenotypic and genetic determinants of disease progression in ALS, and examines established and evolving biomarkers that may contribute to robust measurement in longitudinal clinical studies. With targeted neuroprotective strategies on the horizon, developing efficiencies in clinical trial design may facilitate timely entry of novel treatments into the clinic. Ann Neurol 2014;76:643–657 相似文献
9.
Chopard Romain Campia Umberto Morin Lucas Jering Karola S. Almarzooq Zaid I. Snyder Julia Elizabeth Rizzo Samantha Waxman Aaron B. Goldhaber Samuel Z. Piazza Gregory 《Journal of thrombosis and thrombolysis》2022,54(3):449-460
Journal of Thrombosis and Thrombolysis - Multidisciplinary pulmonary embolism (PE) response teams have garnered widespread adoption given the complexities of managing acute PE and provide a... 相似文献
10.
Yasir H Rather Ajaz A Sheikh Aalia R Sufi Ateeq A Qureshi Zaid A Wani Tasneem S Shaukat 《Child and adolescent psychiatry and mental health》2011,5(1):13-3
Epistaxis is an important otorhinolaryngological emergency, which usually has an apparent etiology, frequently local trauma
in children. Here we present a case report wherein the epistaxis was recalcitrant, and proved to have a psychiatric disorder
as an underlying basis. The child was diagnosed with Attention Deficit/Hyperactivity Disorder, hyperactive type, which led
to trauma to nasal mucosa due to frequent and uncontrolled nose picking. Treatment with atomoxetine controlled the patient's
symptoms and led to a remission of epistaxis. 相似文献