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1.
Schizophrenia is a chronic and severe psychiatric disorder that has profound impact on an individual’s life and on society. Thus, developing more effective therapeutic interventions is essential. Over the past quarter‐century, an abundance of evidence from pharmacologic challenges, post‐mortem studies, brain imaging, and genetic studies supports the role of glutamatergic dysregulation in the pathophysiology of schizophrenia, and the results of recent randomized clinical trials based on this evidence have yielded promising results. In this article, we review the evidence that alterations in glutamatergic neurotransmission, especially focusing on the N‐methyl‐d ‐aspartate receptor (NMDAR) function, may be a critical causative feature of schizophrenia, how this contributes to pathologic circuit function in the brain, and how these insights are revealing whole new avenues for treatment development that could reduce treatment‐resistant symptoms, which account for persistent disability. 相似文献
2.
Kentaro Ariyoshi Yota Hiroyama Naoya Fujiwara Tomisato Miura Kosuke Kasai Akifumi Nakata Yohei Fujishima Valerie Swee Ting Goh Mitsuaki A Yoshida 《Journal of radiation research》2021,62(1):73
Alopecia is one of the common symptoms after high-dose radiation exposure. In our experiments, neonatal mice that received 7 Gy X-ray exhibited defects in overall hair growth, except for their cheeks. This phenomenon might suggest that some substances were secreted and prevented hair follicle loss in the infant tissues around their cheeks after radiation damage. In this study, we focused on exosome-like vesicles (ELV) secreted from cheek skin tissues and back skin tissues, as control, and examined their radiation protective effects on mouse fibroblast cell lines. We observed that ELV from irradiated cheek skin showed protective effects from radiation. Our results suggest that ELV from radiation-exposed cheek skin tissue is one of the secreted factors that prevent hair follicle loss after high-dose radiation. 相似文献
3.
Ken Kamisawa Takeo Kosaka Kohei Nakamura Yota Yasumizu Hiroshi Hongo Toshikazu Takeda Kazuhiro Matsumoto Hiroshi Nishihara Mototsugu Oya 《Cancer science》2022,113(9):3161
The purpose of this study was to investigate factors predicting the sensitivity to cabazitaxel therapy in metastatic castration‐resistant prostate cancer (mCRPC) patients with phosphatase and tensin homolog deleted from chromosome 10 (PTEN) alterations. This single‐institution, retrospective study included 12 mCRPC patients with PTEN alterations who had received cabazitaxel therapy. Five patients (41%) responded to cabazitaxel therapy with a prostate‐specific antigen (PSA) level decline of ≥30% from baseline, and all of them had responded to prior docetaxel therapy with a PSA decline of ≥30%. None of the patients with a poor response to prior docetaxel therapy responded well to cabazitaxel therapy. Of the seven patients who did not respond to cabazitaxel and whose PSA declined from baseline was <30%, five (71%) were also refractory to prior docetaxel therapy. The PSA responses to docetaxel and cabazitaxel were significantly correlated (p = 0.027). Kaplan–Meier analysis revealed that progression‐free survival (PFS) for cabazitaxel was significantly shorter for prior docetaxel nonresponders (3.3 versus 9.1 months, p = 0.028). Multivariate analysis revealed that a poor response to prior docetaxel (PSA decline < 30%) (hazard ratio [HR] = 6.382, 95% confidence interval [CI] 1.172–34.750, p = 0.032) and baseline PSA of ≥20 ng/ml (HR = 33.584, 95% CI 2.332–483.671, p = 0.010) were independent prognostic factors for PFS with cabazitaxel therapy. These results demonstrate cross‐resistance between docetaxel and cabazitaxel. The response to prior docetaxel therapy can influence the sensitivity to cabazitaxel therapy in mCRPC patients with PTEN alterations. 相似文献
4.
Kurahara Hiroshi Mataki Yuko Idichi Tetsuya Kawasaki Yota Mori Shinichiro Sasaki Ken Arigami Takaaki Nakajo Akihiro Fukukura Yoshihiko Higashi Michiyo Ohtsuka Takao 《International journal of clinical oncology / Japan Society of Clinical Oncology》2022,27(7):1212-1221
International Journal of Clinical Oncology - Lymphatic metastasis is a major route of metastasis in distal cholangiocarcinoma (DCC). The present study aimed to elucidate the pattern of lymph node... 相似文献
5.
Taku Fujimura Aya Kakizaki Yumi Kambayashi Yota Sato Kayo Tanita Chunbing Lyu Sadanori Furudate Setsuya Aiba 《Experimental dermatology》2018,27(1):64-70
Together with regulatory T cells (Tregs), tumor‐associated macrophages (TAMs) play roles in maintaining the tumor microenvironment. Although cytotoxic antimelanoma drugs such as dacarbazine (DTIC), nimustine hydrochloride (ACNU) and vincristine (VCR) have been used for the treatment of malignant melanoma as adjuvant therapy in Japan, the detailed mechanisms of their immunomodulatory effects are not fully understood. As the majority of TAMs are alternatively activated M2 macrophages that favour tumor development, the aim of this study was to elucidate the immunomodulatory effects of these reagents on human monocyte‐derived M2 macrophages. First, mRNA expressions and protein production of immune checkpoint molecules, PD‐L1 and chemokines by CD163+ CD206+ M2 macrophages derived from peripheral blood mononuclear cells were investigated to determine the immunomodulatory effects of DTIC, ACNU, and VCR. DTIC and VCR significantly decreased PD‐L1 mRNA expression, which was confirmed by flow cytometry. Moreover, the mRNA expression and production of CCL22 were significantly decreased by DTIC, which suggested that DTIC might suppress the recruitment of Tregs in the tumor site. Furthermore, the decreased expression of PD‐L1 and production of CCL22 were validated in vivo, using the B16F10 mouse melanoma model, leading to abrogation of the suppressive function of T‐cell proliferation. The present report suggests one of the possible antimelanoma mechanisms of DAV combination chemotherapy for melanoma patients. 相似文献
6.
7.
Hisataka Fujiwara Takayuki Suto Akira Umemura Yota Tanahashi Satoshi Amano Kenichiro Ikeda Kazuho Harada Akira Sasaki 《Asian journal of endoscopic surgery》2021,14(3):578-581
We present a rare case of De Garengeot hernia treated with simultaneous laparoscopic appendectomy and transabdominal preperitoneal hernia repair. Our patient was an 85-year-old man with a bulging mass in the right groin. De Garengeot hernia was observed on contrast-enhanced CT. Urgent laparoscopy showed the distal part of the appendix passing through a right-sided femoral hernia. Laparoscopic appendectomy was performed, followed by transabdominal preperitoneal repair of the femoral hernia. Pathological examination revealed ischemic necrosis of the appendix. The patient's postoperative recovery was uneventful. 相似文献
8.
Relationship between joint motion and acceleration during single-leg standing
in healthy male adults
Yota Abe Masaaki Sakamoto Rie Nakazawa Kenji Shirakura 《Journal of Physical Therapy Science》2015,27(4):1251-1256
[Purpose] The purpose of this study was to clarify the relationship between acceleration
and joint movement by synchronizing accelerometers and a three-dimensional motion analysis
system, and to show the utility of an accelerometer as a postural control assessment tool.
[Subjects and Methods] Head, lumbar, shank accelerations and various joint angles during
single-leg standing were measured of 20 healthy males. Root mean squares of acceleration
and joint angle were calculated. Fast Fourier transform analysis was performed for head,
lumbar, and shank accelerations, and the median frequencies were calculated. Then,
principal component analysis was performed for the median frequency of each acceleration.
Stepwise multiple regression analysis was also used to examine the relationship between
joint angle and acceleration. [Results] The score of the first principal component was
highest for shank acceleration, while that of the second principal component was highest
for lumbar and head accelerations. In multiple regression analysis, hip flexion/extension
and adduction/abduction were identified as variables associated with head acceleration.
[Conclusion] We were able to confirm the aggregation of acceleration into two components,
which we interpreted as postural control strategies using primarily the ankle and hip
joints. Furthermore, though multiple regression analysis, we were able to clarify the
joint movement indicated by acceleration of each segment.Key words: Postural control, Acceleration, Ankle sprain 相似文献
9.
Masami YOSHIOKA Daisuke HINODE Yota YAMAMOTO Yoshihito FURUKITA Akira TANGOKU 《Journal of applied oral science : revista FOB》2013,21(2):183-189