Nowadays rare earth elements (REEs) are widely applied in high-technology and clean energy products, but their environmental risks are still largely unknown. To estimate the ecological risk of REEs, soil samples were collected from REE mine tailings with and without phytoremediation. The results showed that the tailings had rather low organic matter and high total REE concentrations, up to 808.5 mg/kg. The 10% effective concentration (EC10) of neodymium (Nd) and yttrium (Y) were calculated based on the toxicity tests of seed germination and root growth. For both wheat and mung bean, the EC10 of Nd and Y in soils were in the range of 1053.1–1300.1 mg/kg. The average hazard quotient of mine tailing soil without phytoremediation was higher than that with phytoremediation. All the hazard quotient of Nd and Y were less than 1, indicating that Nd or Y alone was unlikely to cause adverse ecological effects. Given to the coexistence of REEs on mine sites, the ecological risk of REE mixture could be potentially high towards local soil environments, even for soils with phytoremdiation.
目的:随着各种消化内镜和薄层计算机断层扫描(computed tomography,CT)等技术的临床广泛应用,消化道黏膜下病变(submucosal lesion,SML)的检出率越来越高.针对SML治疗的内镜黏膜下层剥离术(endoscopic submucosal dissection,ESD)、外科手术数量越来越多.对于SML临床转归、ESD或外科手术的必要性及患者是否受益存在争论.本研究主要针对上消化道黏膜下病变的性质、生长速度、恶变可能及ESD或外科手术的必要性、疗效.方法:回顾性分析安徽医科大学附属安徽省立医院2004-01/2014-12经超声内镜(endoscopic ultrasonography,EUS)诊断为消化道SML的1915例患者的临床资料.运用超声内镜观察病变部位(食管、胃),病变大小,回声表现、来源等特征.根据黏膜下病变性质、大小、患者意愿等选择不同治疗方案.包括EUS的随访观察、内镜下治疗[ESD、内镜下黏膜剥离切除术、内镜黏膜下挖除术(endoscopic submucosalexcavation,ESE)、内镜经黏膜下隧道肿瘤切除术]和外科手术(开放手术、胸腔镜腹腔镜)(内镜或外科手术的指证是病灶短期内明显增大或相关内镜或影像评估怀疑有恶变的可能或患者主观要求内镜或手术切除).随访记录病灶的大小变化、切除病变的性质、大小、来源及并发症发生情况(出血、穿孔)、中转手术情况.结果:超声随访1135例SML患者(食道687例,胃448例),平均年龄50.7岁±10.3岁,男女比例为1.16∶1;食道SML初始病灶大小为:0.82 c m±0.24 c m,共计18例病灶随访过程中明显增大包括5例显著增大发生在6 mo内病理结果诊断为3例良性病变(固有肌层平滑肌瘤1例,囊肿2例)及两例恶性病变(平滑肌肉瘤1例,恶性颗粒细胞瘤1例).胃SML初始病灶大小为:1.31 cm±0.44 cm,16例病灶明显增大,包括10例病灶明显增大,病理诊断为2例平滑肌瘤病灶增大发生于12 mo内,8例间质瘤.病灶增大均在6 mo内发生.内镜下手术患者668例(食道412例,胃256例),6例(4例ESE组,2例ESD组)于术中发生穿孔,2例(均为E S E组)于术中发生出血,2例病变未完整剥离,内镜下治疗成功率为98.5%.外科手术患者112例(食道19例,胃93例)两例(GIST及食道平滑肌肉瘤)发生迟发性出血,手术成功率为98.2%.食道SML中,平滑肌瘤占86.1%,GIST占4.9%,囊肿占3%.胃S M L中,G I S T占48.1%,平滑肌瘤占24.9%,异位胰腺占17.3%,囊肿占3.4%,脂肪瘤占2.6%.结论:不论食管还是胃部黏膜下瘤,病灶的显著增大多发生于初次随访后6 mo内,6 mo后变化不明显.食管黏膜下肿瘤以平滑肌瘤为主,间质瘤少见,生长迅速的病灶及恶性病变罕见,食管病变无论外科手术或ESD术创伤及经济代价较大,不建议常规施行.胃部黏膜下病灶以间质瘤多见,迅速生长病灶较食管增多,建议12 mo内随访期间对生长迅速病灶施行ESD或外科手术. 相似文献
BACKGROUND Few studies have addressed the effects of human leukocyte antigen(HLA)alleles on different clinical sub-phenotypes in childhood steroid-sensitive nephrotic syndrome(SSNS),including SSNS without recurrence(SSNSWR)and steroid-dependent nephrotic syndrome/frequently relapse nephrotic syndrome(SDNS/FRNS).In this study,we investigated the relationship between HLA system and children with SSNSWR and SDNS/FRNS and clarified the value of HLA allele detection for precise typing of childhood SSNS.METHODS A total of 241 Chinese Han individuals with SSNS were genotyped using GenCap-WES Capture Kit,and four-digit resolution HLA alleles were imputed from available Genome Wide Association data.The distribution and carrying frequency of HLA alleles in SSNSWR and SDNS/FRNS were investigated.Additionally,logistic regression and mediating effects were used to examine the relationship between risk factors for disease process and HLA system.RESULTS Compared with SSNSWR,significantly decreased serum levels of complement 3(C3)and complement 4(C4)at onset were detected in SDNS/FRNS(C3,P<0.001;C4,P=0.018).The average time to remission after sufficient initial steroid treatment in SDNS/FRNS was significantly longer than that in SSNSWR(P=0.0001).Low level of C4 was further identified as an independent risk factor for SDNS/FRNS(P=0.008,odds ratio=0.174,95% confidence interval 0.048-0.630).The HLA-A*11:01 allele was independently associated with SSNSWR and SDNS/FRNS(P=0.0012 and P=0.0006,respectively).No significant HLA alleles were detected between SSNSWR and SDNS/FRNS.In addition,a mediating effect among HLA-I alleles(HLA-B*15:11,HLA-B*44:03 and HLA-C*07:06),C4 level and SDNS/FRNS was identified.CONCLUSIONS HLA-I alleles provide novel genetic markers for SSNSWR and SDNS/FRNS.HLA-I antigens may be involved in steroid dependent or frequent relapse in children with SSNS as mediators of immunoregulation. 相似文献
We aimed to explore the associations between the age at which children undergo surgery for hypospadias and a range of social and clinical factors in a single ce... 相似文献