Reactions to disaster at a distance. The first week after the earthquake in Soviet Armenia

Armenian-American adolescents from a Los Angeles school were interviewed during the first week after the massive earthquake in Soviet Armenia in December 1988. The authors describe their observations: All the adolescents strongly identified with the victims and felt that the catastrophe personally affected them; they all rushed into hectic activities to escape intolerable grief reactions; there was strong group pressure to accelerate helping efforts; the catastrophe was experienced as fortifying group cohesion; and there was a distinct preference to preserve and strengthen communal values, even over and above helping the earthquake victims. In particular, the authors observed the phenomenon of "participation envy," a special form of survivor guilt involving envious resentment at being excluded from a unique and rallying communal experience.     

Overview of Dietary Supplements in Prostate Cancer

Prostate cancer is a key health concern for men with its etiology still under investigation. Recently, the role of dietary supplements has been noted to have a major inhibitory effect on prostate cancer and numerous studies have been conducted in this regard. This review provides a summary on numerous recent studies conducted in this field. Some of the studies reviewed revealed a protective role for supplements, and others showed no correlation while some even had an adverse effect. The mechanism of how these supplements act on the prostate is still not clear. Further studies are warranted especially for supplements that have been shown to have a potential inhibitory role in prostate cancer.     

Incidence of Sciatic Nerve Palsy After Revision Hip Arthroplasty Through a Posterior Approach

Sciatic nerve palsy after revision hip arthroplasty is rare, but can have substantial impacts. The purpose of this study is to report the safety and reliability of limited sciatic nerve exposure during revision surgery. A retrospective case series of 350 revision hip surgeries performed by a single surgeon underwent sciatic nerve identification. In each case, the sciatic nerve was identified and tagged loosely with a Penrose drain. Three hundred forty-eight of 350 patients (99.4%) underwent successful revision hip arthroplasty. One patient developed a transient sensory palsy; and another patient, a delayed palsy. Both nerve palsies recovered by the 1-year visit. We advocate visual nerve identification and tagging in revision hip surgery as 1 possible method to potentially reduce the risks of sciatic nerve injury.     

Correlates of ecstasy use among high school seniors surveyed through Monitoring the Future

Media reports have suggested that the use of 3,4-methylenedioxymethamphetamine (MDMA or 'ecstasy') is a prodigious problem across the USA. Unfortunately, little scientific evidence exists to support this contention. In the current study, the drug-using behaviors of 1679 high school seniors are examined with data collected in 1999 through the Monitoring the Future (MTF) study. Prevalence estimates of ecstasy use are generated and associations between ecstasy use, demographic characteristics, and alcohol and other drug (AOD) use are explored. Eight percent of the sample reported lifetime ecstasy use, 6% reported use within the past 12 months, and 3% reported use within the past 30 days. Compared to non-users, 12-month ecstasy users were significantly more likely to be white and to have used all other drugs of abuse during the 12 months preceding the interview. Implications for these findings are discussed.     

Estimating the prevalence of Ecstasy use among juvenile offenders

To date, no studies have examined Ecstasy use among criminal justice populations. Focusing on individuals under criminal justice supervision is useful because "new" illegal drugs will typically take root in a criminal population before diffusing to the general population. In the current study, self-report drug use data and urine specimens were collected from 209 juvenile offenders surveyed through Maryland's Offender Population Urinalysis Screening (OPUS) Program. Prevalence estimates are generated and associations between Ecstasy use, demographic characteristics, and alcohol and other drug use are explored. Sixteen percent of the sample reported using Ecstasy within the past 12 months, an estimate almost three times as high as grade school and high school students surveyed through the Monitoring the Future survey. Compared to nonusers. Ecstasy users were significantly more likely to be female (45% versus 20%, p < 0.01), White (82% versus 22%, p < 0.001), and out of school (39% versus 20%, p < 0.05). Associations were also found between Ecstasy use and the use of other drugs. These findings suggest that the recent use of Ecstasy among juvenile offenders is higher than estimated use in the general student population, and that youthful offenders may represent an important population for potential intervention.     

Estimating the prevalence of alcohol and drug abuse and dependence among New Orleans arrestees

The Arrestee Drug Abuse Monitoring Program collects self-report drug use data and urine specimens from adult arrestees across the United States. Despite high levels of drug use among arrestees, few studies have examined need for alcohol and other drug (AOD) treatment within this population. To address this limitation, a secondary analysis was undertaken with a sample of 940 New Orleans arrestees surveyed in 2001. Fifty-nine percent of the sample was diagnosed as needing AOD treatment. Because "need for treatment" was operationalized as a diagnosis of abuse or dependence, the current results should be viewed as liberal estimates of treatment need. Drug treatment implications for criminal populations are discussed.     

Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity

α-synuclein (α-syn) is a main component of Lewy bodies (LB) that occur in many neurodegenerative diseases, including Parkinson's disease (PD), dementia with LB (DLB) and multi-system atrophy. α-syn mutations or amplifications are responsible for a subset of autosomal dominant familial PD cases, and overexpression causes neurodegeneration and motor disturbances in animals. To investigate mechanisms for α-syn accumulation and toxicity, we studied a mouse model of lysosomal enzyme cathepsin D (CD) deficiency, and found extensive accumulation of endogenous α-syn in neurons without overabundance of α-syn mRNA. In addition to impaired macroautophagy, CD deficiency reduced proteasome activity, suggesting an essential role for lysosomal CD function in regulating multiple proteolytic pathways that are important for α-syn metabolism. Conversely, CD overexpression reduces α-syn aggregation and is neuroprotective against α-syn overexpression-induced cell death in vitro. In a C. elegans model, CD deficiency exacerbates α-syn accumulation while its overexpression is protective against α-syn-induced dopaminergic neurodegeneration. Mutated CD with diminished enzymatic activity or overexpression of cathepsins B (CB) or L (CL) is not protective in the worm model, indicating a unique requirement for enzymatically active CD. Our data identify a conserved CD function in α-syn degradation and identify CD as a novel target for LB disease therapeutics.