亚甲蓝甘油合剂封闭治疗三叉神经痛108例

目的观察亚甲蓝甘油合剂封闭治疗三叉神经痛的临床疗效并探讨其治疗机制。方法按国际头面痛学会分类委员会确定的诊断标准,108例原发性三叉神经患者随机分为两组:A组为亚甲蓝甘油合剂组(n=54),B组为单纯甘油合剂组(n=54);采用徐贵印推荐的三维测角穿刺半月神经节进行封闭治疗,对治疗后1周、3个月和2年分别进行疗效评判和随访观察。结果两组治疗后1周、3个月优良率比较差异无统计学意义(P>0.05),两年后优良率比较差异有统计学意义(P<0.05);两组并发症没有明显差异,2例出现视力下降,3例因解剖变异未能穿刺成功,仅在卵圆孔周围进行了注射,外加眶下孔以及骸孔封闭。结论亚甲蓝甘油合剂用于治疗三叉神经痛远期疗效优于单纯甘油合剂,且亚甲蓝对神经未见明显损害(经2年随访)。     

Association of DAAO with schizophrenia in the Chinese population

Recently, the gene called DAAO was reported to be associated with schizophrenia in the French Canadian populations. Here, we report a result obtained in the study of our large collection of 547 schizophrenia cases and 536 controls in the Chinese population. Six single-nucleotide polymorphisms (SNPs) were genotyped at and around the DAAO locus, covering a 10-kb region entirely encompassing the complementary DNA sequences of DAAO. We found statistically significant differences in allele distributions on one marker: SNP rs3741775 (P = 0.0000001). In the haplotype analysis based on the information of linkage-disequilibrium block across this gene locus, we demonstrated a highly significant association between schizophrenia and a DAAO haplotype (P = 2.0173 x 10(-21)), which therefore provides an independent statistical support for association of the DAAO gene with schizophrenia and indicates that the DAAO gene may play a significant role in the etiology of schizophrenia in the Han Chinese.     

高师贫困生自我效能感与主观幸福感的特点及关系研究

目的分析高师贫困生自我效能感、主观幸福感的特点及关系，为心理健康教育提供依据。方法采用一般自我效能感量表、生活满意度量表、快乐感量表，对218名贫困生和216名非贫困生进行测查。结果①高师贫困生生活满意度、快乐感显著低于非贫困生（t=4．811，P〈0．001；t=2．504，P〈0．05），自我效能感差异不显著。②高师贫困生自我效能感存在性别差异（t=2．117，P〈0．05），男生的自我效能感显著高于女生；生活满意度年级差异显著（F=3．547，P〈0．05），大一学生的生活满意度显著高于大二和大三学生，大二和大三之间的差异不显著。③高师贫困生自我效能感与生活满意度、快乐感呈显著正相关（r=0．349，P〈0．01；r=0．436，P〈0．01）。自我效能感水平越高，幸福感越强。结论高师贫困生主观幸福感相对较低，自我效能感与主观幸福感显著相关，通过提升自我效能感水平可以增强主观幸福感。     

乳腺癌患者骨质疏松性椎体骨折相关因素分析

目的探索乳腺癌患者治疗前后的骨质疏松性椎体骨折率及相关影响因素。方法收集478例乳腺癌患者作为病例组与500例无乳腺癌病史的妇女作为对照组,采用Genant半定量方法对治疗前后的病例组和对照组胸部X线侧位片上的胸椎T4至腰椎L1进行评估,比较病例组与对照组椎体骨折率的差异,以及病例组治疗前后椎体骨折率的变化;按年龄、体质指数(BMI)、乳腺癌分子亚型(Luminal A、Luminal B、Triple-Negative及HER2+)、治疗时间、治疗方式进行分组,对影响椎体骨折的相关因素进行单因素分析及多因素Logistic回归分析。结果病例组治疗前的椎体骨折率为12.34%,治疗后的椎体骨折率为19.46%,对照组的椎体骨折率为14.40%;病例组治疗前的椎体骨折率与对照组以及病例治疗后组差异存在统计学意义(P<0.05);多因素Logistic回归分析显示年龄、治疗时间是椎体骨折的主要影响因素(P<0.05)。结论乳腺癌治疗的诸多因素都能增加骨质疏松性椎体骨折的风险,乳腺癌患者治疗后的椎体骨折率高于治疗前。     

北海市医疗卫生机构消毒质量动态分析

本文对广西北海市医疗卫生机构1995～1999年消毒监测资料进行了系统的统计分析。结果表明:①5年间北海市医疗卫生机构的消毒总合格率为81.05％;②市直医疗卫生机构的消毒合格率明显高于个体诊所等其它类别医疗机构的。本文还就如何加强对医疗卫生机构的消毒监测管理工作提出了合理性的建议。     

Efficacy and safety evaluation of human reovirus type 3 in immunocompetent animals: racine and nonhuman primates.

PURPOSE: Human reovirus type 3 has been proposed to kill cancer cells with an activated Ras signaling pathway. The purpose of this study was to investigate the efficacy of reovirus in immunocompetent glioma animal models and safety/toxicity in immunocompetent animals, including nonhuman primates. EXPERIMENTAL DESIGN: Racine glioma cells 9L and RG2 were implanted s.c. or intracranially in Fisher 344 rats with or without reovirus antibodies, followed by treatment of reovirus. To study whether reovirus kills contralateral tumors in the brain and to determine viral distribution, we established an in situ dual tumor model followed by reovirus intratumoral inoculation only into the ipsilateral tumor. To evaluate neurotoxicity/safety of reovirus, Cynomolgus monkeys and immunocompetent rats were given intracranially with reovirus, and pathological examination and/or behavioral studies were done. Viral shedding and clinical biochemistry were systematically studied in monkeys. RESULTS: Intratumorally given reovirus significantly suppressed the growth of both s.c. and intracranially tumors and significantly prolonged survival. The presence of reovirus-neutralizing antibodies did not abort the reovirus' antitumor effect. Reovirus inhibited glioma growth intracranially in the ipsilateral but not the contralateral tumors; viral load in ipsilateral tumors was 15 to 330-fold higher than the contralateral tumors. No encephalitis or behavioral abnormalities were found in monkeys and rats given reovirus intracranially. No treatment-related clinical biochemistry changes or diffuse histopathological abnormality were found in monkeys inoculated intracranially with Good Manufacturing Practice prepared reovirus. Microscopic changes were confined to the region of viral inoculation and were dose related, suggesting reovirus intracranially was well tolerated in nonhuman primates. CONCLUSIONS: These data show the efficacy and safety of reovirus when it is used in the treatment of gliomas in immunocompetent hosts. Inoculation of reovirus into the brain of nonhuman primates did not produce significant toxicities.     

儿童人工耳蜗植入术后神经反应遥测阈值的变化

目的:通过对儿童患者术后神经反应遥测 (NRT) 阈值的分析,总结其变化规律,为儿童人工耳蜗植入术后调试提供帮助.方法:测试40例接受Nucleus CI24R 型多导人工耳蜗单侧植入术的患儿.测试使用澳大利亚Cochlear公司提供的便携式调试系统及NRT3.1版本软件.采用削减算法提取NRT反应波形,分别测试每位患者的第1、5、10、15、20号电极,NRT阈值使用NRT软件计算.分别在开机时、开机3、6和12个月时进行测试.结果:在术后同一测试时间,位于耳蜗不同部位电极的NRT阈值存在差异.耳蜗底部和顶部电极的NRT阈值较低,而位于耳蜗中部的电极NRT阈值较高.经单因素方差分析,不同部位NRT阈值均差异有统计学意义.同一测试电极,随术后开机时间的增长,NRT阈值呈逐渐增加的趋势.经单因素方差分析,术后不同测试时间NRT阈值均差异有统计学意义.结论:术后开机1年内,NRT阈值呈逐渐增加的趋势.若人工耳蜗植入术后调试需要NRT进行辅助,每次均应测试NRT阈值,以便更准确估算患者的行为反应T、C级,尤其对植入术后1年内的儿童患者更为重要.     

金黄色葡萄球菌稳定L型的鉴定及其应用

目的 鉴定从一例恶性淋巴瘤患者骨髓中三次分离出的稳定L型。方法 对此菌株进行了生物学性状观察,免疫细胞化学染色及DNA酶切图谱分析,并以该菌株DNA制备探针,用原位杂交法检测了宫颈癌和子宫内膜癌的组织切片。结果 证实该菌株是金黄色葡萄球菌L型,此探针能检出肿瘤组织中的金葡菌L型DNA。结论 从该恶性淋巴瘤患者骨髓中分离的系金葡菌L型,L型可能与肿瘤有关。