PIA1/A2 polymorphism of the platelet glycoprotein receptor IIb/IIIIa and its correlation with myocardial infarction: an appraisal.

Platelet glycoprotein (GP) IIb/IIIa is a membrane receptor for fibrinogen and von Willebrand factor. There is considerable controversy regarding the clinical role of the GPIIb/IIIa PIA1/A2 as a risk factor for myocardial infarction. A summative analysis is performed on the recent previous reports on the GPIIb/IIIa PIA1/A2 and its correlation to myocardial infarction. The metanalysis was performed to assess the correlation between the pattern of GPIIb/IIIa PIA1/A2 polymorphism and myocardial infarction. From 7 available case-control reports, 553 patients and 1,059 controls are evaluated. The overall frequencies of PIA2 allele for the patients and controls are 0.249 and 0.221, respectively. According to this study, 49.4% of subjects with PIA2 allele have myocardial infarction while 39.5% of subjects without PIA2 allele have cerebrovascular disease. From overall risk estimation, the subjects with PIA2 alleles have a 1.1 times higher risk to have myocardial infarction. According to this analysis, it is proposed that the pattern of GPIIb/IIIa PIA1/A2 polymorphism does not represent a useful marker of increased risk for myocardial infarction. In addition, the lack of association between the pattern of GPIIb/IIIa PIA1/A2 polymorphism and ethnicity of the patients was demonstrated in this study.     

Male Rape,Some Notes on the Laboratory Investigation

The incidence of sexual assault continues to escalate, and it is under-reported. Recent literature discusses the medical, legal, and psychological management of the female sexual assault victim, but little has been written regarding appropriate management of male sexual assault. This article focuses on the laboratory investigation in male rape case.