全文获取类型
收费全文 | 7630篇 |
免费 | 458篇 |
国内免费 | 31篇 |
专业分类
耳鼻咽喉 | 78篇 |
儿科学 | 151篇 |
妇产科学 | 228篇 |
基础医学 | 1421篇 |
口腔科学 | 648篇 |
临床医学 | 582篇 |
内科学 | 1430篇 |
皮肤病学 | 179篇 |
神经病学 | 617篇 |
特种医学 | 169篇 |
外科学 | 943篇 |
综合类 | 43篇 |
一般理论 | 8篇 |
预防医学 | 674篇 |
眼科学 | 130篇 |
药学 | 430篇 |
中国医学 | 68篇 |
肿瘤学 | 320篇 |
出版年
2023年 | 53篇 |
2022年 | 115篇 |
2021年 | 242篇 |
2020年 | 177篇 |
2019年 | 209篇 |
2018年 | 265篇 |
2017年 | 182篇 |
2016年 | 218篇 |
2015年 | 227篇 |
2014年 | 306篇 |
2013年 | 426篇 |
2012年 | 564篇 |
2011年 | 603篇 |
2010年 | 342篇 |
2009年 | 291篇 |
2008年 | 462篇 |
2007年 | 449篇 |
2006年 | 356篇 |
2005年 | 292篇 |
2004年 | 287篇 |
2003年 | 248篇 |
2002年 | 219篇 |
2001年 | 197篇 |
2000年 | 186篇 |
1999年 | 129篇 |
1998年 | 44篇 |
1997年 | 27篇 |
1996年 | 30篇 |
1995年 | 22篇 |
1994年 | 24篇 |
1993年 | 25篇 |
1992年 | 65篇 |
1991年 | 56篇 |
1990年 | 49篇 |
1989年 | 38篇 |
1988年 | 58篇 |
1987年 | 49篇 |
1986年 | 52篇 |
1985年 | 53篇 |
1984年 | 29篇 |
1983年 | 37篇 |
1982年 | 24篇 |
1981年 | 21篇 |
1980年 | 20篇 |
1979年 | 24篇 |
1975年 | 26篇 |
1974年 | 20篇 |
1971年 | 24篇 |
1970年 | 36篇 |
1969年 | 23篇 |
排序方式: 共有8119条查询结果,搜索用时 15 毫秒
1.
2.
3.
Willy Baccaglini Felipe A. Glina Cristiano Linck Pazeto Luis G. Medina Fernando Korkes Wanderley M. Bernardo Rene Sotelo Sidney Glina Giancarlo Marra Marco Moschini Xavier Cathelineau Rafael Sanchez-Salas 《Clinical genitourinary cancer》2021,19(1):3-11.e1
This meta-analysis focuses on the accuracy of upgrading to clinically significant prostate cancer (PCa) by multiparametric magnetic resonance imaging-targeted biopsy (MRI-TB) versus systematic biopsy (SB). We searched the Medline, Embase, Cochrane Central Register of Controlled Trials, Web of Science, Scopus, and Literatura Latino Americana em Ciências da Saúde databases through January 2020 for comparative, retrospective/prospective, paired-cohort, and randomized clinical trials with paired comparisons. The population consisted of patients with low-risk PCa in active surveillance with at least 1 index lesion on imaging. We evaluated the quality of evidence by using the Quality Assessment of Diagnostic Accuracy Studies-2 score. Group comparisons considered the differences between the area under the curve summary receiver operating characteristic curve in a 2-tailed method. We also compared the positive predictive value of the best single method (MRI-TB or SB) and the referral study test (combined biopsy, a combination of MRI-TB and SB). The meta-analysis included 6 studies enrolling 741 patients. The pooled sensitivity for the 2 groups was 0.79 (95% confidence interval, 0.74-0.83; I2 = 75%) and 0.67 (95% confidence interval, 0.63-0.74; I2 = 55.4%), respectively. The area under the curve for the MRI-TB and SB groups were 0.99 and 0.92 (P < .001), respectively. The positive predictive value for the MRI-TB and combined biopsy groups were similar. The accumulated evidence suggests better results for MRI-TB compared with SB. Therefore, use of MRI-TB alone may be preferable in patients in active surveillance harboring low-risk PCa. 相似文献
4.
5.
6.
7.
8.
9.
10.
Flavia M. N. P. Aslanian Maria Teresa Q. Marques Haroldo J. Matos Luciane F. S. Pontes Luis Cristvo S. Porto Lucia M. S. Azevedo Absalom L. Filgueira 《Journal der Deutschen Dermatologischen Gesellschaft》2006,4(10):842-847
Background: Lichen sclerosus (LS) has been identified with increased frequency in families,often associated with HLA markers, mainly DQ7. A genetic co‐etiology seems likely in this setting. Moreover, there is an association of LS with autoimmune disorders, such as the presence of anti‐thyroid peroxidase autoantibodies (anti‐TPO), a hallmark of autoimmune thyroid diseases. Patients and Methods: In 3 families affected by LS, we verified their HLA markers, and identified previously undiagnosed cases of LS and autoimmune disorders. 30 individuals were examined with history, skin biopsy, HLA class I and II typing by PCR‐SSP, and measurement of anti‐TPO, free thyroxine and thyroidstimulating hormones (TSH) levels. Results: There were 8 cases of LS, 50 % of them anti‐TPO+. Autoimmune disorders were found in 40 % (total) and in 87.5 % of those affected. Most common HLA markers were B*15, B*57, CW*03, CW*07, CW*18, DRB1*04, DRB1*07, DRB4*. The three latter have been previously associated with LS. Conclusion: New cases of LS and autoimmune disorders can be detected in first degree relatives of patients with LS. The presence of anti‐TPO antibodies strongly suggests autoimmune thyroiditis. There is intra‐familial association between the haplotype HLA‐B*15 ‐DRB1*04 ‐DRB4* and anti‐TPO,emphasizing their link with thyroiditis. New familial approaches might help to make clear the pathogenesis of LS and its association with autoimmune diseases. 相似文献