全文获取类型
收费全文 | 1860篇 |
免费 | 137篇 |
国内免费 | 22篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 77篇 |
妇产科学 | 54篇 |
基础医学 | 303篇 |
口腔科学 | 25篇 |
临床医学 | 233篇 |
内科学 | 322篇 |
皮肤病学 | 88篇 |
神经病学 | 189篇 |
特种医学 | 59篇 |
外科学 | 228篇 |
综合类 | 11篇 |
预防医学 | 114篇 |
眼科学 | 48篇 |
药学 | 75篇 |
肿瘤学 | 174篇 |
出版年
2023年 | 9篇 |
2022年 | 23篇 |
2021年 | 45篇 |
2020年 | 26篇 |
2019年 | 32篇 |
2018年 | 43篇 |
2017年 | 30篇 |
2016年 | 35篇 |
2015年 | 42篇 |
2014年 | 61篇 |
2013年 | 92篇 |
2012年 | 141篇 |
2011年 | 148篇 |
2010年 | 102篇 |
2009年 | 85篇 |
2008年 | 129篇 |
2007年 | 111篇 |
2006年 | 129篇 |
2005年 | 94篇 |
2004年 | 96篇 |
2003年 | 91篇 |
2002年 | 88篇 |
2001年 | 32篇 |
2000年 | 17篇 |
1999年 | 31篇 |
1998年 | 22篇 |
1997年 | 13篇 |
1996年 | 13篇 |
1995年 | 11篇 |
1994年 | 16篇 |
1993年 | 14篇 |
1992年 | 15篇 |
1991年 | 14篇 |
1990年 | 17篇 |
1988年 | 8篇 |
1987年 | 14篇 |
1986年 | 7篇 |
1985年 | 6篇 |
1983年 | 8篇 |
1982年 | 8篇 |
1981年 | 6篇 |
1980年 | 9篇 |
1979年 | 7篇 |
1978年 | 8篇 |
1977年 | 6篇 |
1974年 | 7篇 |
1972年 | 5篇 |
1971年 | 4篇 |
1970年 | 5篇 |
1961年 | 7篇 |
排序方式: 共有2019条查询结果,搜索用时 31 毫秒
1.
2.
Uta Kraus-Tiefenbacher Lelia Bauer Antonella Scheda Carola Schoeber Joerg Schaefer Volker Steil Frederik Wenz 《BMC cancer》2007,7(1):178
Background
For patients suffering of recurrent breast cancer within the irradiated breast, generally mastectomy is recommended. The normal tissue tolerance does not permit a second full-dose course of radiotherapy to the entire breast after a second breast-conserving surgery (BCS). A novel option is to treat these patients with partial breast irradiation (PBI). This approach is based on the hypothesis that re-irradiation of a limited volume will be effective and result in an acceptable frequency of side effects. The following report presents a single center experience with intraoperative radiotherapy (IORT) during excision of recurrent breast cancer in the previously irradiated breast. 相似文献3.
Septic pelvic thrombophlebitis is an uncommon complication in obstetrics and gynecology that may be difficult to diagnose clinically. Computed tomography (CT), an accurate and noninvasive modality, has greatly aided in the diagnosis of this disorder. In a case of septic pelvic thrombophlebitis complicating second-trimester pregnancy termination, CT enabled the correct diagnosis to be made and treatment to be initiated. 相似文献
4.
Uta Lichter-Konecki Christian Benninger Werner E. Brandeis Peter Matthis Dieter Scheffner 《Pediatric hematology and oncology》1987,4(1):77-85
Thirteen children with acute lymphoblastic leukemia (ALL) were investigated before and during cytotoxic therapy. EEG findings were correlated with the clinical course and the therapy protocol and compared with normal data obtained from 295 healthy children. Frequency analysis of the background activity of the EEG revealed an initial slowing of the background activity prior to therapy and further slowing each time a combination of vincristine (VCR), daunorubicine (DAU) or adriblastine (ADR), prednisone (FRED), and L-asparaginase (L-ASP) was administered. The slowing of the background activity correlated only with the administration of these drugs. DAU, ADR, and FRED are not known to influence the EEG; therefore, VCR and L-ASP remain the primary candidates responsible for the central nervous system alteration. 相似文献
5.
Uta Syrbe Anja Moebes Jürgen Scholze Alexander Swidsinski Yvonne D?rffel 《Hypertension research》2007,30(6):521-528
Circulating monocytes from hypertensive patients show elevated secretion patterns of pro-inflammatory cytokines, an increased expression of adhesion molecules, and an increased adhesion to vascular endothelial cells. We tested the hypothesis that telmisartan, an angiotensin II type 1 (AT(1)) receptor antagonist, reduces the activation of circulating monocytes from hypertensive patients and diminishes the monocyte-endothelial cell adhesion. Monocytes of 20 hypertensive patients and 20 normotensive controls were isolated by density gradient centrifugation and Dynabeads, and the monocyte adhesion to human aortic endothelial cell monolayers was measured by adhesion assays. To characterize monocyte activation we assessed the expression of activity-related cell surface markers that are also involved in monocyte adhesion to endothelial cells, such as CD11a/b and CD54, as well as the chemokine receptors CCR1, CCR2 and CCR5 before and after telmisartan therapy using flow cytometry. Spontaneous adhesion of monocytes from hypertensive patients and the adhesion after stimulation with angiotensin II were significantly increased compared with those in normotensive controls (p<0.05). Treatment of hypertensive patients with the AT(1) receptor antagonist telmisartan significantly diminished the adhesion of circulating monocytes to human endothelial cells (p=0.02) despite the increase in the expressions of CD11b, CD54 and CCR5 after telmisartan therapy. Reducing monocyte adhesion may be a novel beneficial effect of the AT(1) receptor antagonist telmisartan helping to prevent vascular alterations in hypertension. The mechanism of action remains to be elucidated, since reduction in monocyte adhesion was not attributable to changes in adhesion molecule expression. 相似文献
6.
7.
Athena Milatovich Graeme Bolger Tamar Michaeli Uta Francke 《Somatic Cell and Molecular Genetics》1994,20(2):75-86
Cyclic nucleotides are important second messengers that mediate a number of cellular responses to external signals. Cyclic nucleotide phosphodiesterases play a role in signal transduction by regulating the cellular concentrations of these messengers. Here, we have applied Southern analyses of somatic cell hybrid lines and of recombinant inbred (RI) mouse strains as well as fluorescence chromosomal in situ hybridization (FISH) to chromosomally localize five cAMP-specific nucleotide phosphodiesterase genes in human and mouse. GenesDPDE1, DPDE2, DPDE3, andDPDE4 that share sequence homology with theDrosophila dunce gene were assigned to human chromosomes 19 (DPDE1 andDPDE2), 5q12 (DPDE3), and 1p31 (DPDE4) and to mouse chromosomes 8, 9, 13, and 4, respectively. The high-affinity cAMP-specific phosphodiesterase gene (HCP1) was mapped to human chromosome 8q13-q22. Since these genes are potential candidates for involvement in psychiatric or behavioral disorders, knowledge of their chromosomal localizations will facilitate the discovery of their association with disease genes as they are being mapped by linkage studies. 相似文献
8.
J I Wolfsdorf S Ehrlich H S Landy J F Crigler 《The American journal of clinical nutrition》1992,56(3):587-592
To determine the optimal daytime dietary regimen for type 1 glycogen storage disease (GSD), we used uncooked cornstarch (UCS) at a basal glucose production rate (GPR) in single and divided doses, with mixed meals at 0700 and 1700 h. This regimen was compared with a 1.5 times larger single dose of UCS at 0700 h, and with dextrose at GPR at 1200 h. Two-hour UCS loads (amount equal to GPR in 2 h) given with a mixed meal at 0700 h and 180 min later maintained mean blood glucose (BG) concentrations at greater than or equal to 4.2 mmol/L for 300 min. BG was significantly greater from 240 to 300 min compared with a single 4-h UCS load, and at 300 min compared with a single 6-h UCS load. Similar effects were noted when the divided UCS regimen was given with a mixed meal at 1700 h, but not when isoenergetic amounts of dextrose were given on the same schedules with a mixed meal at 1200 h. A daytime schedule of six UCS feedings (with the three main meals and 180 min later) at GPR maintains BG at concentrations that should minimize biochemical abnormalities and optimize clinical outcome in patients with GSD. 相似文献
9.
10.
We describe two cases of type 2 thanatophoric dysplasia. Cloverleaf skull and relatively straight, shortened long bones distinguish this condition from the more common type 1 thanatophoric dysplasia. 相似文献