全文获取类型
收费全文 | 295篇 |
免费 | 7篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 22篇 |
妇产科学 | 7篇 |
基础医学 | 62篇 |
口腔科学 | 2篇 |
临床医学 | 58篇 |
内科学 | 27篇 |
皮肤病学 | 22篇 |
神经病学 | 5篇 |
特种医学 | 5篇 |
外科学 | 14篇 |
综合类 | 5篇 |
预防医学 | 37篇 |
眼科学 | 6篇 |
药学 | 26篇 |
中国医学 | 1篇 |
肿瘤学 | 11篇 |
出版年
2022年 | 4篇 |
2016年 | 4篇 |
2015年 | 3篇 |
2013年 | 6篇 |
2011年 | 3篇 |
2010年 | 5篇 |
2009年 | 4篇 |
2008年 | 5篇 |
2007年 | 13篇 |
2006年 | 6篇 |
2005年 | 4篇 |
2004年 | 4篇 |
2003年 | 7篇 |
2002年 | 10篇 |
2001年 | 8篇 |
2000年 | 7篇 |
1999年 | 6篇 |
1998年 | 4篇 |
1997年 | 7篇 |
1996年 | 7篇 |
1995年 | 4篇 |
1994年 | 3篇 |
1993年 | 4篇 |
1992年 | 7篇 |
1991年 | 8篇 |
1990年 | 16篇 |
1989年 | 13篇 |
1988年 | 4篇 |
1987年 | 4篇 |
1986年 | 4篇 |
1985年 | 8篇 |
1984年 | 10篇 |
1983年 | 5篇 |
1982年 | 5篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1979年 | 5篇 |
1978年 | 7篇 |
1977年 | 12篇 |
1976年 | 6篇 |
1975年 | 7篇 |
1974年 | 8篇 |
1973年 | 9篇 |
1972年 | 6篇 |
1971年 | 3篇 |
1970年 | 4篇 |
1969年 | 8篇 |
1968年 | 3篇 |
1967年 | 4篇 |
1965年 | 2篇 |
排序方式: 共有312条查询结果,搜索用时 15 毫秒
1.
2.
S B Singaevski? S V Grishakov L D Tsvetkova S N Shnitko V A Starikov V I Buravtsov 《Vestnik khirurgii imeni I. I. Grekova》1992,148(5):154-158
Results of a complex clinico-functional examination of 48 patients after resection for lung cancer 8-10 years ago are presented. The satisfactory pumping function of the heart was revealed with practically normal volumes of the cardiac output. Among patients subjected to resection of a lobe of the lung two groups were determined: with relatively satisfactory parameters of the function of external respiration and blood circulation and with a pronounced degree of strain of the functioning of these systems. 相似文献
3.
4.
I. V. Gar'kavtsev T. G. Tsvetkova S. M. Terekhov I. A. Aleksandrov S. P. Mitkevich 《Bulletin of experimental biology and medicine》1989,108(4):1481-1484
Institute of Medical Genetics, Academy of Medical Sciences of the USSR, Moscow. All-Union Mental Health Research Center, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR N. P. Bochkov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 108, No. 10, pp. 479–481. October, 1989. 相似文献
5.
6.
Colorectal cancer is the fourth commonest cancer worldwide. The survival rate is suboptimal for patients with metastatic disease. The introduction of anti-epidermal growth factor receptor (EGFR) antibodies has remarkably improved clinical outcomes. Two monoclonal antibodies targeting EGFR and one multikinase inhibitor have been approved by the FDA and Health Canada for the treatment of metastatic colorectal cancer; however, only about 10 % of patients respond to this treatment. Having wild-type KRAS is necessary but not sufficient to derive benefit from EGFR inhibition. Interestingly, patients with certain mutations such as p.G13D represent a cetuximab-sensitive subtype of KRAS mutant metastatic colorectal cancer. A few biomarkers have been identified, but we still do not know the best way to administer drugs. In this article we review the clinical data and expert opinions and summarize the recommendations. 相似文献
7.
Federica Miglietta Maria Vittoria Dieci Vassilena Tsvetkova Gaia Griguolo Grazia Vernaci Alice Menichetti Giovanni Faggioni Tommaso Giarratano Eleonora Mioranza Elisa Genovesi Enrico Cumerlato Michele Bottosso Tania Saibene Silvia Michieletto Marcello Lo Mele Pierfranco Conte Valentina Guarneri 《The oncologist》2020,25(9):e1355-e1362
8.
F. SCHATZ M. BRÄUTIGAM E. DOBROWOLSKI I. EFFENDY † H. HABERL‡ H. MENSING§ G. WEIDINGER A. STÜTZ 《Clinical and experimental dermatology》1995,20(5):377-383
Patients with toe-nail onychomycosis were treated with terbinafine (250 mg daily, n= 20) for either 6 or 12 weeks in a randomized double-blind study. Plasma and distal nail clippings were taken before initiation of therapy and 1, 6, 12, 18, 24, 36 and 48 weeks thereafter. Analytical data of terbinafine extracted from nail clippings or plasma were obtained by high-performance liquid chromatography (HPLC). Nail extracts and isolated HPLC terbinafine peaks were analysed using a combined gas chromatography - mass spectroscopy system (GC-MS) for unequivocal identification of the drug. Terbinafine could be detected in the distal nail in the majority of the patients within 1 week of starling therapy. Maximum terbinafine levels of 0·52 and 1·01 μg;g were measured after 18 weeks in the 6- and 12-week treatment groups, respectively. While plasma levels decreased rapidly after termination of therapy terbinaiine was detected in the nails as long as 36 weeks (6 weeks treatment) and 36 weeks (12 weeks treatment) after termination of therapy at a range of 0·–0·19 μg/g. The drug concentrations measured at all time points are well above the minimum inhibitory concentration (MIC) tor dermatophytes and other fungi, These data suggest that the drug readies the nail plate rapidly and persists there for several months after cessation of active treatment. 相似文献
9.
I. A. Rudneva E. I. Sklyanskaya O. S. Barulina S. S. Yamnikova V. P. Kovaleva I. V. Tsvetkova N. V. Kaverin 《Archives of virology》1996,141(6):1091-1099
Summary Human-avian and human-mammalian influenza A virus reassortant clones with the neuraminidase (NA) gene of the A/USSR/90/77 (H1N1) strain and hemagglutinin (HA) genes of H3, H4 and H13 subtypes had been shown in an earlier publication to produce low HA yields in the embryonated chicken eggs. The low HA titers had been shown to be due, at least in part, to the formation of virion clusters at 4°C; the clustering was removed by the treatment with bacterial neuraminidase [Rudneva et al., Arch. Virol (1993) 133: 437–450]. By serial passages of the reassortants in chick embryos non-aggregating variants were selected: the variants produced HA titers of the same order as A/USSR/90/77 parent virus. The assessment of the virus yields by the analysis of the partially purified virus preparations from fixed volumes of the allantoic fluid revealed that actual virion yields of the initial reassortants were lower than the yields of their passaged variants or of the parent viruses. The passaged variant of a reassortant possessing the HA gene of A/Duck/Ukraine/1/63 (H3N2) virus differed from the original (non-passaged) reassortant and from the parent A/Duck/Ukraine/1/63 virus in the reaction with a panel of monoclonal antibodies against H3 hemagglutinin. The data suggest that some HA-NA combinations may lead to an incomplete functional match between HA and NA and to the formation of low-yield reassortants, thus representing a possible limiting factor in the emergence of new HA-NA combinations in natural conditions. 相似文献
10.