排序方式: 共有54条查询结果,搜索用时 31 毫秒
1.
Anne Stuedal Inger Torhild Gram Yngve Bremnes Herman Adlercreutz Marit B Veier?d Giske Ursin 《Cancer epidemiology, biomarkers & prevention》2005,14(9):2154-2159
AIMS: Certain phytoestrogens, such as lignans, may protect against developing breast cancer. Enterolactone is a lignan metabolite produced by the intestinal flora from dietary precursors such as whole grains, vegetables, and fruits. Enterolactone has been shown to have weak estrogenic and antiestrogenic properties. We decided to examine the association between plasma levels of enterolactone and mammographic density, a biomarker for breast cancer risk. METHODS: We included data from postmenopausal women ages 55 and older who participated in a cross-sectional mammogram study in Troms?, Norway. Mammograms, plasma enterolactone measurements, as well as information on anthropometric and hormonal/reproduction factors were available on 616 women. We assessed mammographic density using a previously validated computer-assisted method. We estimated correlation coefficients and conducted multiple regression analyses. RESULTS: Mean mammographic density increased slightly across quartiles of enterolactone; the women in the highest quartile had, on average, 3.1% (absolute difference) higher percentage mammographic density compared with the lowest quartile (P(trend) < 0.01). After adjustment for age, body mass index, number of full-term pregnancies, age at first birth, and use of postmenopausal hormone therapy, the mean difference in density was reduced to 2.0% (P(trend) = 0.05). Results were similar when restricted to the 454 current hormone nonusers. The fully adjusted statistical model explained 28.3% of the total variability in mammographic percentage density, with body mass index contributing 18.2% and enterolactone only 0.9%. CONCLUSION: In our study, higher levels of enterolactone were associated with slightly higher percentage mammographic density. Our results suggest that if higher enterolactone levels reduce the risk of developing breast cancer in postmenopausal women, then this effect is not through lowering mammographic density. 相似文献
2.
3.
Linseisen J Rohrmann S Bueno-de-Mesquita B Büchner FL Boshuizen HC Agudo A Gram IT Dahm CC Overvad K Egeberg R Tjønneland A Boeing H Steffen A Kaaks R Lukanova A Berrino F Palli D Panico S Tumino R Ardanaz E Dorronsoro M Huerta JM Rodríguez L Sánchez MJ Rasmuson T Hallmans G Manjer J Wirfält E Engeset D Skeie G Katsoulis M Oikonomou E Trichopoulou A Peeters PH Khaw KT Wareham N Allen N Key T Brennan P Romieu I Slimani N Vergnaud AC Xun WW Vineis P Riboli E 《Cancer causes & control : CCC》2011,22(6):909-918
Evidence from case-control studies, but less so from cohort studies, suggests a positive association between meat intake and risk of lung cancer. Therefore, this association was evaluated in the frame of the European Prospective Investigation into Cancer and Nutrition, EPIC. Data from 478,021 participants, recruited from 10 European countries, who completed a dietary questionnaire in 1992-2000 were evaluated; 1,822 incident primary lung cancer cases were included in the present evaluation. Relative risk estimates were calculated for categories of meat intake using multi-variably adjusted Cox proportional hazard models. In addition, the continuous intake variables were calibrated by means of 24-h diet recall data to account for part of the measurement error. There were no consistent associations between meat consumption and the risk of lung cancer. Neither red meat (RR = 1.06, 95% CI 0.89-1.27 per 50 g intake/day; calibrated model) nor processed meat (RR = 1.13, 95% CI 0.95-1.34 per 50 g/day; calibrated model) was significantly related to an increased risk of lung cancer. Also, consumption of white meat and fish was not associated with the risk of lung cancer. These findings do not support the hypothesis that a high intake of red and processed meat is a risk factor for lung cancer. 相似文献
4.
The significance of meaningful and enjoyable activities for nursing home resident's experiences of dignity 下载免费PDF全文
?shild Sletteb? PhD Berit S?teren PhD Synn?ve Caspari PhD Vibeke Lohne PhD Arne Wilhelm Rehnsfeldt PhD Anne Kari Tolo Heggestad PhD Britt Lillest? PhD Bente H?y PhD Maj‐Britt R?holm PhD Lillemor Lindwall PhD Trygve Aasgaard PhD Dagfinn N?den PhD 《Scandinavian journal of caring sciences》2017,31(4):718-726
5.
Campa D Claus R Dostal L Stein A Chang-Claude J Meidtner K Boeing H Olsen A Tjønneland A Overvad K Rodríguez L Bonet C Sánchez MJ Amiano P Huerta JM Barricarte A Khaw KT Wareham N Travis RC Allen NE Trichopoulou A Bamia C Benetou V Palli D Agnoli C Panico S Tumino R Sacerdote C van Kranen H Bas Bueno-de-Mesquita H Peeters PH van Gils CH Lenner P Sund M Lund E Gram IT Rinaldi S Chajes V Romieu I Engel P Boutron-Ruault MC Clavel-Chapelon F Siddiq A Riboli E Canzian F Kaaks R 《Breast cancer research and treatment》2011,127(3):761-767
AMP-activated protein kinase (AMPK) is an energy sensing/signalling intracellular protein which is activated by an increase in the cellular AMP:ATP ratio after ATP depletion. Once activated, AMPK inhibits fatty acid synthesis and the Akt-mTOR pathway, and activates the p53-p21 axis. All these molecular mechanisms are thought to play a key role in breast carcinogenesis. We investigated the genetic variability of four genes encoding AMPK (PRKAA1, PRKAA2, PRKAB1 and PRKAB2). Using a tagging approach and selecting SNPs we covered all the common genetic variation of these genes. We tested association of tagging SNPs in our four candidate genes with breast cancer (BC) risk in a study of 1340 BC cases and 2536 controls nested into the European Prospective Investigation into Cancer and Nutrition (EPIC). Given the relevance of AMPK on fatty acid synthesis and the importance of body fatness as a BC risk factor, we tested association of SNPs and body-mass index as well. We observed no statistically significant association between the SNPs in the PRKAs genes and BC risk and BMI after correction for multiple testing. 相似文献
6.
Solbakk Jan Helge Bentzen Heidi Beate Holm Søren Heggestad Anne Kari Tolo Hofmann Bjørn Robertsen Annette Alnæs Anne Hambro Cox Shereen Pedersen Reidar Bernabe Rose 《Medicine, health care, and philosophy》2021,24(1):3-20
Medicine, Health Care and Philosophy - The Covid-19 pandemic creates an unprecedented threatening situation worldwide with an urgent need for critical reflection and new knowledge production, but... 相似文献
7.
Lifetime and baseline alcohol intakes and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition study 下载免费PDF全文
Sabine Naudin Kuanrong Li Tristan Jaouen Nada Assi Cecilie Kyr? Anne Tj?nneland Kim Overvad Marie‐Christine Boutron‐Ruault Vinciane Rebours Anne‐Laure Védié Heiner Boeing Rudolf Kaaks Verena Katzke Christina Bamia Androniki Naska Antonia Trichopoulou Franco Berrino Giovanna Tagliabue Domenico Palli Salvatore Panico Rosario Tumino Carlotta Sacerdote Petra H. Peeters H. B Bueno‐de‐Mesquita Elisabete Weiderpass Inger Torhild Gram Guri Skeie Maria‐Dolores Chirlaque Miguel Rodríguez‐Barranco Aurelio Barricarte Jose Ramón Quirós Miren Dorronsoro Ingegerd Johansson Malin Sund Hanna Sternby Kathryn E. Bradbury Nick Wareham Elio Riboli Marc Gunter Paul Brennan Eric J. Duell Pietro Ferrari 《International journal of cancer. Journal international du cancer》2018,143(4):801-812
Recent evidence suggested a weak relationship between alcohol consumption and pancreatic cancer (PC) risk. In our study, the association between lifetime and baseline alcohol intakes and the risk of PC was evaluated, including the type of alcoholic beverages and potential interaction with smoking. Within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, 1,283 incident PC (57% women) were diagnosed from 476,106 cancer‐free participants, followed up for 14 years. Amounts of lifetime and baseline alcohol were estimated through lifestyle and dietary questionnaires, respectively. Cox proportional hazard models with age as primary time variable were used to estimate PC hazard ratios (HR) and their 95% confidence interval (CI). Alcohol intake was positively associated with PC risk in men. Associations were mainly driven by extreme alcohol levels, with HRs comparing heavy drinkers (>60 g/day) to the reference category (0.1–4.9 g/day) equal to 1.77 (95% CI: 1.06, 2.95) and 1.63 (95% CI: 1.16, 2.29) for lifetime and baseline alcohol, respectively. Baseline alcohol intakes from beer (>40 g/day) and spirits/liquors (>10 g/day) showed HRs equal to 1.58 (95% CI: 1.07, 2.34) and 1.41 (95% CI: 1.03, 1.94), respectively, compared to the reference category (0.1–2.9 g/day). In women, HR estimates did not reach statistically significance. The alcohol and PC risk association was not modified by smoking status. Findings from a large prospective study suggest that baseline and lifetime alcohol intakes were positively associated with PC risk, with more apparent risk estimates for beer and spirits/liquors than wine intake. 相似文献
8.
Merethe S. Hansen Idlir Licaj Tonje Braaten Eiliv Lund Inger Torhild Gram 《British journal of cancer》2021,124(3):658
Background We examined the association between active and passive smoking and lung cancer risk and the population attributable fraction (PAF) of lung cancer due to active smoking, in the Norwegian Women and Cancer Study, a nationally representative prospective cohort study.Methods We followed 142,508 women, aged 31–70 years, who completed a baseline questionnaire between 1991 and 2007, through linkages to national registries through December 2015. We used Cox proportional hazards models, to estimate hazard ratios (HRs) with 95% confidence intervals (CIs). We calculated PAF to indicate what proportion of lung cancer cases could have been prevented in the absence of smoking.Results During the more than 2.3 million person-years of observation, we ascertained 1507 lung cancer cases. Compared with never smokers, current (HR 13.88, 95% CI 10.18–18.91) smokers had significantly increased risk of lung cancer. Female never smokers exposed to passive smoking had a 1.3-fold (HR 1.34, 95% CI 0.89–2.01) non- significantly increased risk of lung cancer, compared with never smokers. The PAF of lung cancer was 85.3% (95% CI 80.0–89.2).Conclusion More than 8 in 10 lung cancer cases could have been avoided in Norway, if the women did not smoke.Subject terms: Epidemiology, Oncology 相似文献
9.
Chuang SC Gallo V Michaud D Overvad K Tjønneland A Clavel-Chapelon F Romieu I Straif K Palli D Pala V Tumino R Sacerdote C Panico S Peeters PH Lund E Gram IT Manjer J Borgquist S Riboli E Vineis P 《Cancer causes & control : CCC》2011,22(3):487-494
The association between childhood environmental tobacco smoke (ETS) exposure and adult cancer risk is controversial; we examined this relationship in never smokers within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Over an average of 10 years, 8,372 cases of cancer were diagnosed in 112,430 never smokers in EPIC. Childhood ETS was self-reported by participants at baseline, along with other lifestyle factors. Hazard ratios (HR) for ETS exposure in childhood and their 95% confidence intervals (CI) were estimated by Cox proportional hazards models stratified by age, sex, and study center and adjusted for education, alcohol drinking, body mass index, physical activity, non-alcoholic energy intake, fruit and vegetable intake, and adulthood ETS exposure. Models were further adjusted for reproductive factors for female cancers, for meat intake for digestive system cancers, and for diabetes status for pancreatic cancer. No association was observed between childhood ETS exposure and overall cancer risks (HR = 0.97, 95% CI = 0.92-1.02), and for selected sites. The only exception was pancreatic cancer, as previously reported by Vrieling et al., among those who had been exposed daily in childhood (overall HR = 2.09, 95% CI = 1.14-3.84). In conclusion, childhood ETS exposure might not be a major risk factor for common cancers in adulthood. 相似文献
10.