全文获取类型
收费全文 | 537篇 |
免费 | 39篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 34篇 |
妇产科学 | 1篇 |
基础医学 | 80篇 |
口腔科学 | 8篇 |
临床医学 | 55篇 |
内科学 | 126篇 |
皮肤病学 | 26篇 |
神经病学 | 9篇 |
特种医学 | 7篇 |
外科学 | 37篇 |
综合类 | 10篇 |
一般理论 | 1篇 |
预防医学 | 22篇 |
眼科学 | 62篇 |
药学 | 70篇 |
中国医学 | 3篇 |
肿瘤学 | 21篇 |
出版年
2024年 | 2篇 |
2023年 | 4篇 |
2022年 | 15篇 |
2021年 | 45篇 |
2020年 | 13篇 |
2019年 | 23篇 |
2018年 | 21篇 |
2017年 | 17篇 |
2016年 | 13篇 |
2015年 | 22篇 |
2014年 | 29篇 |
2013年 | 42篇 |
2012年 | 60篇 |
2011年 | 55篇 |
2010年 | 29篇 |
2009年 | 11篇 |
2008年 | 23篇 |
2007年 | 34篇 |
2006年 | 24篇 |
2005年 | 17篇 |
2004年 | 24篇 |
2003年 | 11篇 |
2002年 | 8篇 |
2001年 | 6篇 |
2000年 | 5篇 |
1999年 | 5篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1994年 | 1篇 |
1990年 | 2篇 |
1988年 | 2篇 |
1985年 | 1篇 |
1984年 | 2篇 |
1983年 | 3篇 |
1982年 | 2篇 |
1979年 | 2篇 |
1968年 | 1篇 |
1967年 | 1篇 |
排序方式: 共有578条查询结果,搜索用时 15 毫秒
1.
Inhibition of interleukin-2 production by adherent cell factors from lepromatous leprosy patients. 总被引:1,自引:2,他引:1 下载免费PDF全文
I Nath J Jayaraman M Sathish L K Bhutani A K Sharma 《Clinical and experimental immunology》1984,58(3):531-538
Twenty-four hour supernatants (MoF) were obtained from monocyte rich 2 h adherent cells of 19 leprosy patients and four healthy contacts. MoF from borderline and lepromatous patients produced 52-61% inhibition of human interleukin-2 (IL-2) production by a PHA conditioned T cell line (Jurkat). Non-adherent cell supernatants and MoF from tuberculoid and healthy individuals had little effect on IL-2 production. The suppression effected by MoF was in the first 12 h of initiation of PHA stimulated Jurkat cell cultures. Suppressive MoF did not interfere with (1) IL-2 release, (2) IL-2 utilization by Con A-induced T cell blasts or (3) constitutive proliferation of Jurkat cells. Such MoF were released spontaneously from adherent cells of bacilliferous leprosy patients but required in vitro antigen triggering in long term treated lepromatous patients. It is possible that the unresponsiveness associated with lepromatous leprosy is related to the inhibition of IL-2 production by suppressive factors, thereby, preventing the further expansion of antigen reactive T cells. 相似文献
2.
HPV DNA in plasma of patients with cervical carcinoma. 总被引:4,自引:0,他引:4
Narayanan Sathish Priya Abraham Abraham Peedicayil Gopalan Sridharan Subhashini John R V Shaji George Chandy 《Journal of clinical virology》2004,31(3):204-209
BACKGROUND: HPV DNA has been detected in metastatic tumour and HPV plasma viraemia may indicate a poor prognosis and a high risk for metastasis. OBJECTIVE: Detection of HPV DNA in plasma of patients with cervical carcinoma. STUDY DESIGN: A cross-sectional study was done, wherein cervical biopsies and plasma samples were collected from 58 women with invasive cervical carcinoma, 10 women with cervical intraepithelial neoplasia (CIN) and 30 control women in the same age range. Polymerase chain reaction (PCR) was employed to detect the presence of HPV DNA. Samples positive for HPV DNA were typed by restriction fragment length polymorphism (RFLP). To confirm that the HPV sequence in plasma was identical to that in tissue, sequencing was done on all the paired plasma and tissue samples. RESULTS: All the 30 paired cervical tissue and plasma samples from the controls were negative for HPV DNA. HPV DNA was detectable in cervical tissues of 55 (94.8%) of 58 patients with invasive cervical carcinoma and in all 10 patients (100%) with CIN and in eight (11.8%) of the total 68 plasma samples from patients. All eight plasma samples were from women with invasive cervical carcinoma with three each in stages IIIB and IV and one each in stages IIB and IB, respectively. Of the eight positive samples, seven were typed as HPV-16 and 1 as HPV-58. HPV types detected in cervical tissue and plasma pairs from these eight patients correlated as revealed by RFLP and sequencing. A patient with stage IB cancer had detectable HPV DNA in the external iliac lymph node, removed at Wertheims hysterectomy, which was histopathologically free of tumour. The HPV type in the node, was the same as that present in the paired tissue and plasma sample. CONCLUSIONS: HPV DNA is detectable in the plasma of patients with advanced cervical cancer. 相似文献
3.
4.
5.
6.
7.
Katherine R. Amato Marie-Claire Arrieta Meghan B. Azad Michael T. Bailey Josiane L. Broussard Carlijn E. Bruggeling Erika C. Claud Elizabeth K. Costello Emily R. Davenport Bas E. Dutilh Holly A. Swain Ewald Paul Ewald Erin C. Hanlon Wrenetha Julion Ali Keshavarzian Corinne F. Maurice Gregory E. Miller Geoffrey A. Preidis Laure Segurel Burton Singer Sathish Subramanian Liping Zhao Christopher W. Kuzawa 《Proceedings of the National Academy of Sciences of the United States of America》2021,118(25)
Individuals who are minoritized as a result of race, sexual identity, gender, or socioeconomic status experience a higher prevalence of many diseases. Understanding the biological processes that cause and maintain these socially driven health inequities is essential for addressing them. The gut microbiome is strongly shaped by host environments and affects host metabolic, immune, and neuroendocrine functions, making it an important pathway by which differences in experiences caused by social, political, and economic forces could contribute to health inequities. Nevertheless, few studies have directly integrated the gut microbiome into investigations of health inequities. Here, we argue that accounting for host–gut microbe interactions will improve understanding and management of health inequities, and that health policy must begin to consider the microbiome as an important pathway linking environments to population health. 相似文献
8.
Chorea is a neurological adverse effect of oral contraceptive pills (OCPs). The onset of chorea following OCPs usage varies widely from few weeks to several years. We report a rare case of chorea which developed within a week of starting OCPs in an adolescent girl with polycystic ovarian disease.KEY WORDS: Chorea, oral contraceptive pills, polycystic ovarian disease 相似文献
9.
Sampath Marimuthu Abdul Abdul Rahuman Arivarasan Vishnu Kirthi Thirunavukkarasu Santhoshkumar Chidambaram Jayaseelan Govindasamy Rajakumar 《Parasitology research》2013,112(12):4105-4112
The developments of resistance and persistence to chemical insecticides and concerns about the non-target effects have prompted the development of eco-friendly mosquito control agents. The aim of this study was to investigate the larvicidal activities of synthesized cobalt nanoparticles (Co NPs) using bio control agent, Bacillus thuringiensis against malaria vector, Anopheles subpictus and dengue vector, Aedes aegypti (Diptera: Culicidae). The synthesized Co NPs were characterized by X-ray diffraction (XRD), Fourier transform infrared (FTIR), Field-emission scanning electron microscopy (FESEM) with energy dispersive X-ray spectroscopy, and Transmission electron microscopy (TEM). XRD analysis showed three distinct diffraction peaks at 27.03°, 31.00°, and 45.58° indexed to the planes 102, 122, and 024, respectively on the face-centered cubic cobalt acetate with an average size of 85.3 nm. FTIR spectra implicated role of the peak at 3,436 cm?1 for O–H hydroxyl group, 2924 cm?1 for methylene C–H stretch in the formation of Co NPs. FESEM analysis showed the topological and morphological appearance of NPs which were found to be spherical and oval in shape. TEM analysis showed polydispersed and clustered NPs with an average size of 84.81 nm. The maximum larvicidal mortality was observed in the cobalt acetate solution, B. thuringiensis formulation, and synthesized Co NPs against fourth instar larvae of A. subpictus and A. aegypti with LC50 values of 29.16, 8.12, 3.59 mg/L; 34.61, 6.94, and 2.87 mg/L; r 2 values of 0.986, 0.933, 0.942; 0.962, 0.957, and 0.922, respectively. 相似文献
10.