The influence of HLA-matched sibling donor availability on treatment outcome for patients with AML: an analysis of the AML 8A study of the EORTC Leukaemia Cooperative Group and GIMEMA

To determine whether patients with a HLA-identical sibling donor have a better outcome than patients without a donor, an analysis on the basis of intention-to-treat principles was performed within the framework of the EORTC-GIMEMA randomized phase III AML 8A trial. Patients in complete remission (CR) received one intensive consolidation course. Patients with a histocompatible sibling donor were then allocated allogeneic bone marrow transplantation (alloBMT), the patients without a donor were randomized between autologous BMT (ABMT) and a second intensive consolidation (IC2). 831 patients <46 years old and alive >8 weeks from diagnosis were included. HLA typing was performed in 672 patients. AlloBMT was performed during CR1 in 180 (61%) out of 295 patients with a donor. Another 38 patients were allografted: five in resistant disease, 14 during relapse and 19 in CR2. ABMT was performed in 130 (34%) out of 377 patients without a donor in CR1, in six (2%) patients during relapse and in 38 (10%) patients during CR2. The disease-free survival (DFS) from CR for patients with a donor was significantly longer than for patients without a donor (46% v 33% at 6 years; P = 0.01, RR 0.78, 95% confidence interval 0.63–0.96). The overall survival from diagnosis for patients with a donor was longer, but not statistically significant, than for patients without a donor (48% v 40% at 6 years; logrank P = 0.24). When patients were stratified according to prognostic risk groups, the same trend in favour of patients with a donor was seen for survival duration and the DFS remained significantly longer for this group of patients.     

Stressful life events and disability in early rheumatoid arthritis

The objective was to investigate the relationship of stressfullife events and disability in early rheumatoid arthritis (RA),taking into account a possible stress-buffering effect of thesocial network. As part of a European study (EURIDISS), 337early RA patients in France and The Netherlands (mean diseaseduration = 2.3 years) were interviewed for life events whichhad occurred in the past year. The social network compositionwas assessed using a standardized interview schedule and describedby network density and proximity characteristics. Disabilitywas assessed with the Health Assessment Questionnaire (HAQ)cross-culturally adapted to the French and Dutch languages.Subjects reported a median of 2 significant life events overthe past year. On average they had 20 persons in their socialnetwork. The disability was significantly higher when the numberof life events experienced was higher (r = 0.11; p<0.05)and when the number of social network members in monthly contactwith the subjects was lower (r = –0.13; p<0.05). Controllingfor country, the HAQ score increased significantly with thedisease duration, disease activity variables, number of lifeevents related to RA or to another health problem and decreasedwith the number of social network members. A significant (numberof health-related life events)x(number of social network members)cross-product term entered the model which fitted the data better(R² =0.51). Factors associated with disability are disease duration,disease activity, number of health-related life events and numberof social network members in monthly contact. The results suggesta stress-buffering effect of the social network in coping withstressful life events in early RA.     

Total serum haemolytic complement activity, erythrocyte sedimentation rate and plasma fibrinogen as indicators of the stage in Hodgkin''s disease

Total serum haemolytic complement activity, plasma fibrinogen, erythrocyte sedimentation rate and other biological values in forty-three patients with Hodgkin's disease were correlated with results of staging. A highly significant increase (P=10(-5)) of the mean total serum haemolytic complement activity was found in stages IIIA and IVA and in all stages with systemic symptoms. The complement activity in patients with less extensive disease without systemic symptoms (stages IA and IIA) did not show a significant increase over the controls. The best initial parameters correlating well with disease activity were complement activity, ESR and fibrinogen level. It is concluded that total serum haemolytic complement activity gives additional information and can be helpful in differentiating between favourable and unfavourable forms of Hodgkin's disease.     

Detection of depressive complaints in children

This article deals with the detection of depressive complaintsin 10–11 year old children. The results of routine examinationsof children by school nurses are compared with the screeningresults on the Short Depression Inventory for Children (SDIC).It was not possible to predict the presence of depressive complaints,as detected by the SDIC, from the items routinely collectedby the nurses, despite the fact that some of these items werehighly associated with the presence of depressive complaints.The interest in screening large populations of children fordepressive complaints is discussed. Conditions for introducingmass-screening procedures are described.     

Life events and low birthweight—analysis by infants preterm and small for gestational age

Summary. Social stress was assessed in 92 women with low-birthweight babies and 92 controls using the detailed LEDS measure of life events and severe chronic difficulties. The low-birthweight group was divided into preterm delivery (  n = 40  ), small for gestational age (SGA) (  n = 40  ) and mixed groups. Multivariate analysis was performed using a bino-mial-logit model to examine whether social factors were independently and significantly associated with low birthweight once the effect of demographic factors, obstetric factors and smoking/drinking were taken into account. Comparison of preterm births with controls indicated that three factors were significantly associated: a previous low-birthweight baby, severe life event/difficulty and bleeding during pregnancy. For SGA babies the factors were: previous low-birthweight baby, low social support and smoking. By using a reliable measure of life events and adequate numbers of low-birthweight babies, this study overcame the potential inaccuracies of previous studies and indicates a more specific relation between social stress and low birthweight.     

Surgical Treatment of Hidradenitis Suppurativa with Gentamicin Sulfate: A Prospective Randomized Study

BACKGROUND AND METHOD This article describes and discusses a prospective randomized study with gentamicin sulfate in the surgical treatment of hidradenitis suppurativa. The purpose of the study was to investigate whether enclosure of antibiotics after primary excision and closure reduces the number of postoperative infections. Therefore, the hidradenitis lesions were excised and closed with or without enclosure of a gentamicin-collagen sponge (GC).
RESULTS A total of 200 patients were included in the study. Seventy-six patients underwent surgical excision with primary closure (PC), and 124 PCs over a GC. After 1 week there were significantly fewer complications (infection, dehiscence, etc.) in the GC group, 35% versus 52%; after 3 months the complications in both groups were comparable, 12% versus 19% ( Table 2 ). The mean period of wound healing was 21 days in the first group and 24 days in the second group. The recurrence rate after 3 months was comparable in both groups, 40% versus 42%.  

  TABLE 2.   Results: Complications One Week and Three Months Postoperative     

8.

Does Caffeine Affect Cerebral Blood Flow in the Preterm Infant?     

FRANK VAN  BEL  MARGOT VAN de  BOR  THEO STIJNEN  JAN BAAN  JAN H. RUYS 《Acta paediatrica (Oslo, Norway : 1992)》1989,78(2):205-209

ABSTRACT. Caffeine, used for treatment of idiopathic apnea in preterm infants, may have a vasoconstrictive effect on cerebral vessels. The ensuing reduction in cerebral blood flow may play a role in the pathogenesis of ischemic brain damage. In 25 preterm infants possible changes in cerebral blood flow due to caffeine administration were assessed using Doppler ultrasound. During caffeine treatment PaCO₂ was reduced. However, no changes were found in cerebral blood flow velocity suggesting absence of major changes in cerebrovascular resistance and actual cerebral blood flow following caffeine medication.     

9.

ROYAL AUSTRALIAN COLLEGE OF OPHTHALMOLOGISTS 17th ANNUAL CONGRESS, 1985: POLITICS, ETHICS AND THE ROYAL AUSTRALIAN COLLEGE OF OPHTHALMOLOGISTS     

THEO KELDOULIS 《Clinical & experimental ophthalmology》1986,14(1):1-4

     

10.

Art Therapy and Anger
Focusing‐Oriented Art Therapy     

THEO STICKLEY 《Journal of psychiatric and mental health nursing》2010,17(10):950-953

     

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Does Caffeine Affect Cerebral Blood Flow in the Preterm Infant?

ABSTRACT. Caffeine, used for treatment of idiopathic apnea in preterm infants, may have a vasoconstrictive effect on cerebral vessels. The ensuing reduction in cerebral blood flow may play a role in the pathogenesis of ischemic brain damage. In 25 preterm infants possible changes in cerebral blood flow due to caffeine administration were assessed using Doppler ultrasound. During caffeine treatment PaCO₂ was reduced. However, no changes were found in cerebral blood flow velocity suggesting absence of major changes in cerebrovascular resistance and actual cerebral blood flow following caffeine medication.