全文获取类型
收费全文 | 3989篇 |
免费 | 236篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 33篇 |
儿科学 | 255篇 |
妇产科学 | 43篇 |
基础医学 | 507篇 |
口腔科学 | 93篇 |
临床医学 | 286篇 |
内科学 | 813篇 |
皮肤病学 | 37篇 |
神经病学 | 257篇 |
特种医学 | 185篇 |
外科学 | 448篇 |
综合类 | 76篇 |
一般理论 | 1篇 |
预防医学 | 257篇 |
眼科学 | 394篇 |
药学 | 279篇 |
1篇 | |
中国医学 | 15篇 |
肿瘤学 | 256篇 |
出版年
2023年 | 32篇 |
2022年 | 61篇 |
2021年 | 121篇 |
2020年 | 73篇 |
2019年 | 84篇 |
2018年 | 98篇 |
2017年 | 69篇 |
2016年 | 82篇 |
2015年 | 96篇 |
2014年 | 158篇 |
2013年 | 165篇 |
2012年 | 296篇 |
2011年 | 274篇 |
2010年 | 163篇 |
2009年 | 139篇 |
2008年 | 230篇 |
2007年 | 252篇 |
2006年 | 226篇 |
2005年 | 213篇 |
2004年 | 203篇 |
2003年 | 135篇 |
2002年 | 124篇 |
2001年 | 102篇 |
2000年 | 87篇 |
1999年 | 76篇 |
1998年 | 28篇 |
1997年 | 23篇 |
1996年 | 17篇 |
1995年 | 22篇 |
1994年 | 14篇 |
1993年 | 15篇 |
1992年 | 34篇 |
1991年 | 38篇 |
1990年 | 42篇 |
1989年 | 45篇 |
1988年 | 28篇 |
1987年 | 33篇 |
1986年 | 32篇 |
1985年 | 27篇 |
1984年 | 21篇 |
1983年 | 19篇 |
1982年 | 14篇 |
1981年 | 22篇 |
1980年 | 13篇 |
1979年 | 32篇 |
1977年 | 16篇 |
1975年 | 17篇 |
1973年 | 13篇 |
1972年 | 13篇 |
1970年 | 13篇 |
排序方式: 共有4236条查询结果,搜索用时 15 毫秒
1.
2.
Fayiqa Ahamed Bahkir Srinivasan Subramanian Grandee 《Indian journal of ophthalmology》2020,68(11):2378
Purpose:Since the declaration of the lockdown due to COVID-19, the usage of digital devices has gone up across the globe, resulting in a challenge for the visual systems of all ages. The purpose of this study is to assess the impact of the lockdown on digital device usage, and consequently, the ocular surface health implications and circadian rhythm abnormalities related to digital eye strain.Methods:An open online survey was sent through various social media platforms and was open for a period of 2 weeks.Results:A total of 407 usable responses were obtained; the average age of respondents was 27.4 years. Typically, 93.6% of respondents reported an increase in their screen time since the lockdown was declared. The average increase in digital device usage was calculated at about 4.8 ± 2.8 h per day. The total usage per day was found to be 8.65 ± 3.74 hours. Sleep disturbances have been reported by 62.4% of people. Typically, 95.8% of respondents had experienced at least one symptom related to digital device usage, and 56.5% said that the frequency and intensity of these symptoms increased since the lockdown was declared.Conclusion:The study highlighted the drastic increase in use of digital devices after the initiation of the COVID-19 lockdown, and along with it, the slow deterioration of ocular health across all age groups. Awareness about prevention of digital eye strain should be stressed, and going forward, measures to bring these adverse effects to a minimum should be explored. 相似文献
3.
4.
The goals of this report are: 1) to review the number needed to treat (NNT) concept, which, although well established in many sectors of medicine, is still relatively new to the radiotherapy community; 2) to discuss several clinical radiotherapy examples illustrating the inherent advantages of the NNT approach; and 3) to discuss potential future roles of the NNT concept within radiotherapy. 相似文献
5.
Radhika Srinivasan Raje Nijhawan Upasana Gautam Pradeep Bambery 《Diagnostic cytopathology》1994,10(4):383-384
A case of primary amyloidosis, initially detected by fine-needle aspiration of the liver, is reported here. Amorphous acellular metachromatic material was seen extracellularly in between the hepatocytic cords compressing them. This material showed typical apple-green birefringence under crossed bipolars after alkaline Congo-red staining proved its amyloid nature. It was resistant to potassium permanganate pretreatment, indicating it to be of the AL type. © 1994 Wiley-Liss, Inc. 相似文献
6.
7.
Amyloid plaque deposition involves the aggregation of normally soluble proteins into insoluble amyloid fibrils (fibrillization) and proceeds through intermediates with distinct morphologies, including spherical aggregates, protofibrils, and mature fibrils. Recently, a novel annular protofibril-like intermediate with unique pore-like properties was produced by alpha-synuclein, A beta-Arctic and amylin, which are proteins associated with Parkinson's disease, Alzheimer's disease, and type-II diabetes. The observation of annular structures coupled with size selective channel-like activity by these proteins suggests that these structures may be responsible for vesicle permeability by ion-channel formation. Using atomic force spectroscopy, we report here that the ABri peptide associated with familial British dementia produces similar annular and ring-like protofibril structures during the following sequence of events: spherical aggregates (0.4-1.5 nm height)-->chain-like protofibrils (1.5-2.3 nm height)-->ring-like protofibrils and annular protofibrils (1.5-2.3 nm height). This suggests that ABri fibrillization occurs in a similar fashion to other amyloidogenic proteins and that the annular protofibrillar structures may represent a common amyloid intermediate. 相似文献
8.
J B Croft J L Cresanta L S Webber S R Srinivasan D S Freedman G L Burke G S Berenson 《Southern medical journal》1988,81(3):341-9, 353
Fasting serum lipids, lipoprotein cholesterol, and other cardiovascular disease risk factors were examined in 321 natural parents of children with low and/or high levels of beta- and pre-beta-lipoprotein cholesterol. Parents of children from low pre-beta-lipoprotein groups had elevated alpha- and lower pre-beta-lipoprotein cholesterol levels. Parents whose children had high beta-lipoprotein cholesterol levels also had high serum total and beta-lipoprotein cholesterol levels. Parents of children with high levels of both beta- and pre-beta-lipoprotein cholesterol had a high prevalence of both abnormal risk factor levels, as well as clinical evidence of early coronary artery disease (before age 50 years). These observations show that parents of children with high beta- and/or pre-beta-lipoprotein cholesterol levels have greatly enhanced risk for cardiovascular disease, and children mirror their parents' lipoprotein cholesterol levels. These observations emphasize the need for cardiovascular risk evaluation early in life, especially in high-risk families. 相似文献
9.
Arterial wall injury and proteoglycan changes in atherosclerosis 总被引:1,自引:0,他引:1
G S Berenson B Radhakrishnamurthy S R Srinivasan P Vijayagopal E R Dalferes 《Archives of pathology & laboratory medicine》1988,112(10):1002-1010
The concept of injury as a mechanism leading to atherosclerosis has been fostered by numerous studies of initiating factors and by observation of the response of cardiovascular connective tissue, ie, cellular and extracellular matrix components. Carbohydrate-protein macromolecules of the extracellular matrix are a complex group of biologically important substances that play a crucial role in mesenchymal tissue repair following injury, a process needed to maintain arterial wall integrity. Of particular interest are the proteoglycans that enter into a variety of roles, from that of inhibiting atherosclerosis and helping to maintain fibrillar structures to that of taking part in lipid deposition in the development of atherosclerosis. 相似文献
10.
Background. The Bogalusa Heart Study, a long-term epidemiologic investigation of the early natural history of atherosclerosis, was conducted for the first time in 1973-1974 on children from birth through the age of 14 in a biracial (black-white) population. Methods. The emergence of clinically recognizable abnormalities (obesity, hypertension, and hyperlipidemia) was studied in 1,928 young adults, ages 19-32 years, examined in the 1988-1991 survey. Results. The occurrence of morbid levels of cardiovascular disease risk factors varied by race and gender. The prevalence of severe overweight, body mass index ≥ 31.1 kg/m2 for males and ≥ 32.3 kg/m2 for females, was much higher for black women (20.1%) than for white women (8.7%), black men (14.0%), or white men (11.7%). The frequency of hypertension [systolic blood pressure (BP) ≥ 140 mm Hg, diastolic BP ≥ 90 mm Hg, or treatment for high BP] was greatest for black women (13.9%) versus black men (10.1%), white men (6.2%), or white women (5.0%). Approximately 9.5% of the men and 6% of the women had elevated LDL cholesterol (≥160 mg/dl), while elevated triglycerides (≥250 mg/dl) ranged from 0% in black females to 7.4% in white males. Dyslipoproteinemia related to HDL cholesterol (≤35 mg/dl) was more marked among white men (16%) compared with the other groups (approximately 4%). Correlations for risk factors in a subgroup of 1,587 individuals initially surveyed as children in 1973-1974 were examined as an indication of tracking over a 15-year period. Highly significant correlations were seen for obesity, blood pressure, and LDL cholesterol. Conclusion. Early identification of adverse levels of cardiovascular disease risk factors defined by clinical experience should help to predict and prevent future cardiovascular disease morbidity and mortality. 相似文献