全文获取类型
收费全文 | 706篇 |
免费 | 64篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 21篇 |
妇产科学 | 4篇 |
基础医学 | 93篇 |
口腔科学 | 21篇 |
临床医学 | 71篇 |
内科学 | 110篇 |
皮肤病学 | 29篇 |
神经病学 | 94篇 |
特种医学 | 67篇 |
外科学 | 94篇 |
综合类 | 24篇 |
预防医学 | 24篇 |
眼科学 | 14篇 |
药学 | 60篇 |
中国医学 | 3篇 |
肿瘤学 | 47篇 |
出版年
2022年 | 3篇 |
2021年 | 24篇 |
2020年 | 7篇 |
2019年 | 14篇 |
2018年 | 25篇 |
2017年 | 18篇 |
2016年 | 16篇 |
2015年 | 21篇 |
2014年 | 22篇 |
2013年 | 49篇 |
2012年 | 28篇 |
2011年 | 32篇 |
2010年 | 22篇 |
2009年 | 23篇 |
2008年 | 26篇 |
2007年 | 36篇 |
2006年 | 32篇 |
2005年 | 25篇 |
2004年 | 16篇 |
2003年 | 30篇 |
2002年 | 22篇 |
2001年 | 20篇 |
2000年 | 26篇 |
1999年 | 22篇 |
1998年 | 21篇 |
1997年 | 18篇 |
1996年 | 17篇 |
1995年 | 10篇 |
1994年 | 10篇 |
1993年 | 16篇 |
1992年 | 13篇 |
1991年 | 8篇 |
1990年 | 10篇 |
1989年 | 4篇 |
1988年 | 9篇 |
1987年 | 9篇 |
1986年 | 10篇 |
1985年 | 7篇 |
1984年 | 3篇 |
1983年 | 5篇 |
1982年 | 4篇 |
1981年 | 5篇 |
1980年 | 8篇 |
1979年 | 3篇 |
1978年 | 3篇 |
1976年 | 5篇 |
1975年 | 4篇 |
1972年 | 4篇 |
1971年 | 5篇 |
1970年 | 2篇 |
排序方式: 共有779条查询结果,搜索用时 15 毫秒
1.
2.
Summary— KR31080 (2-butyl-5-methyl-6-(1-oxopyridin-2-yl)-3-[[2'-(1H-tetrazol-5-yl) biphenyl-4-yl]methyl]-3H-imidazo[4,5-b] pyridine) is a potent inhibitor of angiotensin type 1 (AT1 ) receptors in rabbit aorta and human recombinant AT1 receptors. In the isolated rabbit thoracic aorta, KR31080 caused a nonparallel shift to the right of the concentration-response curves to angiotensin II (All) with decreased maximal response (pD'2 = 10.1 ± 0.1), but had no effect on the contractile response induced by norepinephrine. KR31080 inhibited specific [125 I]AII binding to rabbit aortic membranes (AT, receptors) and [125 I][Sar1 , Ile8 ]AII binding to human recombinant AT1 receptors in a concentration-dependent manner with IC50 values of 0.84 ± 0.08 nM and 1.92 ± 0.15 nM, respectively, but did not inhibit specific [125 I)AII binding to bovine cerebellum membranes (ÀT2 receptors). In the Scatchard analysis, KR31080 interacted with rabbit aortic AT1 receptors in a competitive manner, similar to losartan. These results demonstrate that KR31080 is a potent and AT1 selective angiotensin receptor antagonist which exerts a competitive antagonism in the [125 I]AII binding assay and insurmountable AT1 receptor antagonism in the functional study. 相似文献
3.
4.
Lily Shum A B M Rabie Urban H?gg 《American journal of orthodontics and dentofacial orthopedics》2004,125(2):185-190
This study assessed the amount of vascular endothelial growth factor (VEGF) expression and related the findings to new bone formation in the posterior glenoid fossa during stepwise mandibular advancement. A total of 250 female Sprague-Dawley rats, 35 days old, were randomly divided into 10 groups, each including 5 control and 20 experimental rats. Within each group, 10 experimental rats were fitted with functional appliances with a 1-step advancement of 3.5 mm. Another 10 were fitted with stepwise appliances with an initial advancement of 2 mm and a subsequent increase to 3.5 mm on day 30. The rats in the experimental groups were killed on days 3, 7, 14, 21, 30, 33, 37, 44, 51, and 60, respectively. The matched controls were killed on the same time points. Sections (7 microm) were cut through the glenoid fossa sagittally and stained with anti-VEGF antibody. VEGF expression in the posterior glenoid fossa was evaluated with a computer-assisted image-analyzing system. Both VEGF expression and new bone formation were greater in the experimental rats than in the controls. During stepwise advancement, initial VEGF expression was less than that of 1-step advancement, but the second advancement elicited another peak on day 44. New bone formation was also less than that of 1-step advancement during early stages of stepwise advancement but then began to increase from day 37 onward. The maximum increase was observed on day 60. Stepwise advancement of the mandible delivers mechanical stimuli that produce a series of tissue responses that lead to increased vascularization and bone formation. 相似文献
5.
TF Leung WC Tsoi CK Li KW Chik MMK Shing PMP Yuen 《Acta paediatrica (Oslo, Norway : 1992)》1998,87(6):705-777
We describe a 15-y-old girl with Fechtner-like syndrome, who is the first Chinese reported to have this rare syndrome. She presented with left homonymous hemianopia and neuroimaging revealed haemorrhage in both parietal and occipital lobes. Peripheral blood smear showed macrothrombocytopenia and intracytoplasmic inclusion bodies inside leucocytes. Thrombocytopenia and proteinuria responded to intravenous immunoglobulin and pulsed methylprednisolone. This case illustrates that life-threatening haemorrhage can occur in patients with Fechtner syndrome. Although there was no effective treatment reported in the literature, high dose steroid and immunoglobulin seemed to be useful in our patient. Our patient also had nephritic-nephrotic syndrome with renal insufficiency, which is unusual in adolescent female patients. 相似文献
6.
Metastatic tumours of the testes are uncommon, making up little more than 2% of all testicular neoplasms. The most frequent primary sites are the lung and prostate. Only rarely do these lesions present clinically either as the first sign of malignant disease or as a complicating factor during the course of known disease. The authors present two cases illustrating both of these occurrences. The first, a man with carcinoma of the common bile duct, initially had a mass in the testicle and the second, a patient with carcinoma of the prostate, had his clinical course complicated by a symptomatic metastasis to the right testis. The authors also reviewed their local autopsy experience and identified 16 more cases. Metastases were grossly visible in 38% (6 of 16). The most frequent primary sites were lung (four cases), stomach (four) and prostate (three). Routes of spread as well as possible explanations for the low incidence are discussed. 相似文献
7.
A method has been derived for calculating the mean absorption time of an oral drug and its interconversion metabolite which is generated from the drug systemically and presystemically. The method evolves from the convolution integral and requires plasma AUC and AUMC values after separate intravenous administration of the drug and its interconversion metabolite and oral administration of the drug. It can also be used to calculate the mean input time of a drug undergoing reversible metabolism and administered by any other extravascular route. Results of a simulation study using both errorless and errant data indicate that, when the absorption rate constant of a drug or its interconversion metabolite is not much larger than the apparent elimination rate constant, the proposed method performs satisfactorily. However, when the absorption rate constant of a drug or its interconversion metabolite is much larger than the apparent elimination rate constant, the proposed method appears to be inaccurate. 相似文献
8.
9.
Five female patients and one male patient with solid and papillary epithelial neoplasms of the pancreas were examined with computed tomography (CT). The mean age of the patients was 27 years (range, 13-46 years). All cases showed well-encapsulated, round or lobulated masses consisting of both cystic and solid areas. Cystic portions showed CT numbers that suggested hemorrhagic necrosis. There were no internal septations within the masses. In three tumors located in the head of the pancreas, dilatation of the biliary tree was absent or minimal, although the masses were large. Two tumors contained calcifications. One tumor demonstrated metastatic deposits in liver and lymph nodes. Metastatic masses appeared similar to the primary pancreatic mass. Solid and papillary neoplasm of the pancreas should be the primary diagnostic consideration when characteristic CT findings are detected in a young female patient. 相似文献
10.
Tarsometatarsal joint: anatomic details on MR images 总被引:3,自引:0,他引:3