West Nile virus encephalitis with myositis and orchitis

This report documents the hospital course and autopsy findings of a 43-year-old man with a renal allograft who died of West Nile virus (WNV) encephalitis. Central nervous system (CNS) findings were those of severe necrotizing and hemorrhagic encephalitis affecting gray matter regions limited to the diencepahlon, rhombencephalon, spinal cord, and limbic system. The bilateral process exhibited preferential involvement of motor neurons. Brain imaging obtained 6 days before death demonstrated an unusual pattern of involvement corresponding with the autopsy findings, confirming that imaging may be a specific diagnostic guide in WNV encephalitis. Extra-CNS findings include myositis with T-lymphocyte infiltration of nerve fibers, suggesting that the virus may reach the CNS via peripheral nerves. Orchitis with dense T-lymphocyte infiltration and syncytial cell formation thought to be due to WNV were also noted.     

Action of remantadine on fusion of the lipid envelope of influenza a virus with plasma and internal membranes in lymphoblastoid cells

Department of Biomembranes, Research Center for Development and Introduction of Modern Methods of Molecular Diagnosis, Ministry of Health of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR I. P. Ashmarin.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 109, No. 5, pp. 483–485, May, 1990.     

Surgical treatment of fractures of the tibial condyli]

Problems of diagnosis, choice of the therapeutic tactics, and the results of operative treatment in 23 patients with various fractures of the tibial condyles are analysed. Computed tomography of the knee joint is recommended for precise diagnosis of injuries to the proximal metaepiphysis of the tibia. The authors recommend an operative intervention in any displacement of a condyle (condyles) in patients of mature age and in fractures of a condyle (condyles) without displacement but combined with other intraarticular injuries (to the ligaments, menisci) which are corrected in one-stage with osteosynthesis. The choice of the method for osteosynthesis is determined by the character and direction of the plane of the fracture, and the manipulation may be carried out with AO compression screws or an AO supporting plate on screws. Primary autospongiosoplasty is recommended in all cases of condylar fractures with depression of the articular cartilage. The performance of stable osteosynthesis makes it possible to decline immobilization of the knee joint in the postoperative period even after primary restoration of the collateral ligaments. Study of the late-term results of treatment confirm the expediency of wider introduction of these methods into trauma-tological practice.