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The genome sequence analysis of H5N1 avian influenza A virus isolated from the outbreak among poultry populations in Thailand 总被引:16,自引:0,他引:16
Viseshakul N Thanawongnuwech R Amonsin A Suradhat S Payungporn S Keawchareon J Oraveerakul K Wongyanin P Plitkul S Theamboonlers A Poovorawan Y 《Virology》2004,328(2):169-176
In this report, the genome of the Thai avian influenza virus A (H5N1); A/Chicken/Nakorn-Pathom/Thailand/CU-K2/04, isolated from the Thai avian influenza A (AI) epidemic during the early of 2004 was sequenced. Phylogenetic analyses were performed in comparison to AI viruses from Hong Kong 1997 outbreaks and other AI (H5N1) isolates reported during 2001-2004. Molecular characterization of the Thai AI (H5N1) HA gene revealed a common characteristic of a highly pathogenic AI (HPAI), a 20-codon deletion in the neuraminidase gene, a 5-codon deletion in the NS gene and polymorphisms of the M2 and PB2 genes. Moreover, the HA and NA genes of the Thai AI displayed high similarity to those of the AI viruses isolated from human cases during the same epidemic. Finally, our results demonstrated that the Thai AI emerged as a member of 2000's AI lineage with most of the genetic sequences closely related to the Influenza A/Duck/China/E319.2/03 (H5N1). 相似文献
2.
Amonsin A Choatrakol C Lapkuntod J Tantilertcharoen R Thanawongnuwech R Suradhat S Suwannakarn K Theamboonlers A Poovorawan Y 《Emerging infectious diseases》2008,14(11):1739-1742
A surveillance program for influenza A viruses (H5N1) was conducted in live bird and food markets in central Thailand during July 2006-August 2007. Twelve subtype H5N1 viruses were isolated. The subtype H5N1 viruses circulating in the markets were genetically related to those that circulated in Thailand during 2004-2005. 相似文献
3.
Negative impact of porcine reproductive and respiratory syndrome virus infection on the efficacy of classical swine fever vaccine 总被引:1,自引:0,他引:1
Suradhat S Kesdangsakonwut S Sada W Buranapraditkun S Wongsawang S Thanawongnuwech R 《Vaccine》2006,24(14):2634-2642
Recent findings suggest that porcine reproductive and respiratory syndrome virus (PRRSV) possesses immunomodulatory properties. To investigate the effect of PRRSV infection on classical swine fever (CSF) vaccine efficacy, 17-day-old pigs were divided into five groups. The experimental group was infected with a Thai PRRSV (US genotype) a week before CSF vaccination and challenged with a virulent CSF virus (CSFV) 3 weeks following vaccination. The control groups received no PRRSV infection, no CSF vaccination, no CSF challenge, or in combination were included. The results demonstrated that PRRSV infection significantly inhibited host immune response that resulted in vaccination failure in the subsequent CSFV exposure. Following CSF challenge, the PRRSV-infected, vaccinated pigs exhibited clinical, virological and pathological features resembled to those of the non-vaccinated groups. The findings indicated that CSF immunization during an acute phase of PRRSV infection could result in vaccination failure. 相似文献
4.
Genetic characterization of H5N1 influenza A viruses isolated from zoo tigers in Thailand 总被引:12,自引:0,他引:12
Amonsin A Payungporn S Theamboonlers A Thanawongnuwech R Suradhat S Pariyothorn N Tantilertcharoen R Damrongwantanapokin S Buranathai C Chaisingh A Songserm T Poovorawan Y 《Virology》2006,344(2):480-491
The H5N1 avian influenza virus outbreak among zoo tigers in mid-October 2004, with 45 animals dead, indicated that the avian influenza virus could cause lethal infection in a large mammalian species apart from humans. In this outbreak investigation, six H5N1 isolates were identified and two isolates (A/Tiger/Thailand/CU-T3/04 and A/Tiger/Thailand/CU-T7/04) were selected for whole genome analysis. Phylogenetic analysis of the 8 gene segments showed that the viruses clustered within the lineage of H5N1 avian isolates from Thailand and Vietnam. The hemagglutinin (HA) gene of the viruses displayed polybasic amino acids at the cleavage site, identical to those of the 2004 H5N1 isolates, which by definition are highly pathogenic avian influenza (HPAI). In addition, sequence analyses revealed that the viruses isolated from tigers harbored few genetic changes compared with the viruses having infected chicken, humans, tigers and a leopard isolated from the early 2004 H5N1 outbreaks. Sequence analyses also showed that the tiger H5N1 isolated in October 2004 was more closely related to the chicken H5N1 isolated in July than that from January. Interestingly, all the 6 tiger H5N1 isolates contained a lysine substitution at position 627 of the PB2 protein similar to the human, but distinct from the original avian isolates. 相似文献
5.
Donruethai Sreta Siriporn Tantawet Suparlark N. Na Ayudhya Aunyaratana Thontiravong Manoosak Wongphatcharachai Jiradej Lapkuntod Napawan Bunpapong Ranida Tuanudom Sanipa Suradhat Linda Vimolket Yong Poovorawan Roongroje Thanawongnuwech Alongkorn Amonsin Pravina Kitikoon 《Emerging infectious diseases》2010,16(10):1587-1590
A swine influenza outbreak occurred on a commercial pig farm in Thailand. Outbreak investigation indicated that pigs were co-infected with pandemic (H1N1) 2009 virus and seasonal influenza (H1N1) viruses. No evidence of gene reassortment or pig-to-human transmission of pandemic (H1N1) 2009 virus was found during the outbreak. 相似文献
6.
Brief report: molecular characterization of a novel reassorted pandemic H1N1 2009 in Thai pigs 总被引:1,自引:0,他引:1
Kitikoon P Sreta D Na Ayudhya SN Wongphatcharachai M Lapkuntod J Prakairungnamthip D Bunpapong N Suradhat S Thanawongnuwech R Amonsin A 《Virus genes》2011,43(1):1-5
For the past 10 years, endemic swine influenza H1 viruses in Thailand have been characterized as reassortants of swine virus
genes from swine influenza viruses (SIV) in US and European pigs. Here the authors report the emergence of a novel reassorted
H1N1 (rH1N1) virus consisted of human, avian, and swine virus genes from the pandemic H1N1 2009 (pH1N1) virus with a neuraminidase
(NA) gene from a Thai swine H1N1 (ThH1N1) isolate. The rH1N1 virus was detected in nursery pigs during a respiratory disease
outbreak in central Thailand in early 2010. The rH1N1 virus was repeatedly isolated from infected pigs, suggesting that it
can transmit efficiently among the pig population. The appearance of rH1N1 virus in the field occurred within months of the
introduction of pH1N1 virus into the Thai swine population in late 2009. The finding highlights the role of pig in generating
newly reassorted influenza A viruses and also the significance of continuing disease surveillance and genetic characterization
of SIV in pigs. 相似文献
7.
Napawan Bunpapong Kamonpan Charoenkul Chanakarn Nasamran Ekkapat Chamsai Kitikhun Udom Supanat Boonyapisitsopa Rachod Tantilertcharoen Sawang Kesdangsakonwut Navapon Techakriengkrai Sanipa Suradhat Roongroje Thanawongnuwech Alongkorn Amonsin 《Emerging infectious diseases》2021,27(8):2208
To investigate an outbreak of African horse sickness (AHS) on a horse farm in northeastern Thailand, we used whole-genome sequencing to detect and characterize the virus. The viruses belonged to serotype 1 and contained unique amino acids (95V,166S, 660I in virus capsid protein 2), suggesting a single virus introduction to Thailand. 相似文献
8.
Napawan Bunpapong Nutthawan Nonthabenjawan Supassama Chaiwong Ratanaporn Tangwangvivat Supanat Boonyapisitsopa Waleemas Jairak Ranida Tuanudom Duangduean Prakairungnamthip Sanipa Suradhat Roongroje Thanawongnuwech Alongkorn Amonsin 《Virus genes》2014,48(1):56-63
In January 2012, several clinical cases of dogs with flu-like symptoms, including coughing, sneezing, nasal discharge, and fever, were reported in a small-animal hospital located in Bangkok, Thailand. One influenza A virus was identified and characterized as an avian-like influenza virus H3N2. The virus was named A/canine/Thailand/CU-DC5299/12. A phylogenetic analysis indicated that the canine virus belonged to an avian Eurasian lineage and was genetically related to the canine influenza viruses H3N2 from China and Korea. This canine virus displays a unique genetic signature with two amino acid insertions in the NA protein, which is similar to the canine influenza viruses from eastern China (Zhejiang and Jiangsu). This study constitutes the first report of H3N2 canine influenza virus infection in a small-animal hospital in Thailand. 相似文献
9.
Amonsin A Chutinimitkul S Pariyothorn N Songserm T Damrongwantanapokin S Puranaveja S Jam-On R Sae-Heng N Payungporn S Theamboonlers A Chaisingh A Tantilertcharoen R Suradhat S Thanawongnuwech R Poovorawan Y 《Virus research》2006,122(1-2):194-199
Three major outbreaks of avian influenza (AI) occurred in Thailand. During the third episode in October 2005, we have isolated H5N1 viruses from one human case and three poultry cases. The whole genomes of AI viruses from human, chickens and quail from the outbreaks were characterized. Sequence analysis of eight gene segments revealed that the 2005 H5N1 viruses isolated in October 2005 were closely related to those recovered from chicken, tiger(s) and human(s) in January and July 2004. In addition, the genetic changes of the AI isolates at the HA cleavage site have been observed. 相似文献
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