全文获取类型
收费全文 | 242篇 |
免费 | 59篇 |
专业分类
儿科学 | 3篇 |
基础医学 | 25篇 |
临床医学 | 77篇 |
内科学 | 47篇 |
皮肤病学 | 1篇 |
神经病学 | 47篇 |
特种医学 | 8篇 |
外科学 | 19篇 |
综合类 | 3篇 |
预防医学 | 65篇 |
药学 | 3篇 |
肿瘤学 | 3篇 |
出版年
2023年 | 9篇 |
2022年 | 1篇 |
2021年 | 3篇 |
2020年 | 11篇 |
2019年 | 7篇 |
2018年 | 22篇 |
2017年 | 15篇 |
2016年 | 16篇 |
2015年 | 19篇 |
2014年 | 20篇 |
2013年 | 37篇 |
2012年 | 8篇 |
2011年 | 11篇 |
2010年 | 9篇 |
2009年 | 18篇 |
2008年 | 11篇 |
2007年 | 9篇 |
2006年 | 10篇 |
2005年 | 7篇 |
2004年 | 10篇 |
2003年 | 2篇 |
2002年 | 7篇 |
2001年 | 2篇 |
2000年 | 5篇 |
1999年 | 8篇 |
1998年 | 8篇 |
1997年 | 3篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1994年 | 2篇 |
1992年 | 2篇 |
1991年 | 1篇 |
1990年 | 2篇 |
1989年 | 1篇 |
1984年 | 1篇 |
1980年 | 1篇 |
1965年 | 1篇 |
排序方式: 共有301条查询结果,搜索用时 15 毫秒
1.
Interprofessional collaboration and communication in nursing homes: a qualitative exploration of problems in medical care for nursing home residents – study protocol 下载免费PDF全文
2.
3.
Rutschmann S Jung AC Zhou R Silverman N Hoffmann JA Ferrandon D 《Nature immunology》2000,1(4):342-347
We have generated, by ethylmethane sulfonate mutagenesis, loss-of-function mutants in the Drosophila homolog of the mammalian I-kappa B kinase (IKK) complex component IKK gamma (also called NEMO). Our data show that Drosophila IKK gamma is required for the Relish-dependent immune induction of the genes encoding antibacterial peptides and for resistance to infections by Escherichia coli. However, it is not required for the Toll-DIF-dependent antifungal host defense. The results indicate distinct control mechanisms of the Rel-like transactivators DIF and Relish in the Drosophila innate immune response and show that Drosophila Toll does not signal through a IKK gamma-dependent signaling complex. Thus, in contrast to the vertebrate inflammatory response, IKK gamma is required for the activation of only one immune signaling pathway in Drosophila. 相似文献
4.
Functional magnetic resonance imaging evidence for binocular interactions in human visual cortex 总被引:3,自引:0,他引:3
Büchert M Greenlee MW Rutschmann RM Kraemer FM Luo F Hennig J 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2002,145(3):334-339
Using functional magnetic resonance imaging (fMRI), we explored the binocular interactions occurring when subjects viewed dichoptically presented checkerboard stimuli. A flickering radial checkerboard was presented to each eye of the subject, while T2*-weighted images were acquired over the visual cortex with gradient-echo, echoplanar sequences. We compared responses in striate and extrastriate visual cortex under four conditions: both eyes were stimulated at the same time (binocular condition), each eye was stimulated in alternation (monocular condition) or first the one eye then the other eye was stimulated (left eye first - right eye trailing, or vice versa). The results indicate that only the striate area, in and near the calcarine fissure, shows significant differences for these stimulation conditions. These differences are not evident in more remote extrastriate or associational visual areas, although the BOLD response in the stimulation-rest comparison was robust. These results suggest that the effect could be related to inhibitory interactions across ocular dominance columns in striate visual cortex. 相似文献
5.
Inpatient dependency in activities of daily living predicts informal caregiver strain: A cross‐sectional study 下载免费PDF全文
6.
7.
Anette Johnsson RN RNT Petra Wagman PhD Reg. OT Åse Boman PhD RN RNT Sandra Pennbrant PhD RN RNT 《Journal of clinical nursing》2018,27(7-8):e1651-e1659
8.
Stacy Schantz Wilkins PhD Rebecca J. Melrose PhD Katherine S. Hall PhD Erin Blanchard MS Steven C. Castle MD Teresa Kopp PT MBA Leslie I. Katzel MD PhD Alice Holder MHS PT Neil Alexander MD Michelle K.S. McDonald BA OT Arti Tayade MD CMD HMDC Daniel E. Forman MD Lauren M. Abbate MD PhD Rebekah Harris PT DPT PhDc Willy M. Valencia MD Miriam C. Morey PhD Cathy C. Lee MD 《Journal of the American Geriatrics Society》2021,69(4):1045-1050
9.
Jacqueline AM Smith DL Patil OT Daniels Y-S Ding J-D Gallezot S Henry KHS Kim S Kshirsagar WJ Martin GP Obedencio E Stangeland PR Tsuruda W Williams RE Carson ST Patil 《The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)》2015,18(2)
Background:
Monoamine reuptake inhibitors exhibit unique clinical profiles that reflect distinct engagement of the central nervous system (CNS) transporters.Methods:
We used a translational strategy, including rodent pharmacokinetic/pharmacodynamic modeling and positron emission tomography (PET) imaging in humans, to establish the transporter profile of TD-9855, a novel norepinephrine and serotonin reuptake inhibitor.Results:
TD-9855 was a potent inhibitor of norepinephrine (NE) and serotonin 5-HT uptake in vitro with an inhibitory selectivity of 4- to 10-fold for NE at human and rat transporters. TD-9855 engaged norepinephrine transporters (NET) and serotonin transporters (SERT) in rat spinal cord, with a plasma EC50 of 11.7ng/mL and 50.8ng/mL, respectively, consistent with modest selectivity for NET in vivo.Accounting for species differences in protein binding, the projected human NET and SERT plasma EC50 values were 5.5ng/mL and 23.9ng/mL, respectively. A single-dose, open-label PET study (4–20mg TD-9855, oral) was conducted in eight healthy males using the radiotracers [11C]-3-amino-4- [2-[(di(methyl)amino)methyl]phenyl]sulfanylbenzonitrile for SERT and [11C]-(S,S)-methylreboxetine for NET. The long pharmacokinetic half-life (30–40h) of TD-9855 allowed for sequential assessment of SERT and NET occupancy in the same subject. The plasma EC50 for NET was estimated to be 1.21ng/mL, and at doses of greater than 4mg the projected steady-state NET occupancy is high (>75%). After a single oral dose of 20mg, SERT occupancy was 25 (±8)% at a plasma level of 6.35ng/mL.Conclusions:
These data establish the CNS penetration and transporter profile of TD-9855 and inform the selection of potential doses for future clinical evaluation. 相似文献10.