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To our knowledge, only 3 patients with an extragonadal germ cell tumor of the prostate have been described in the literature until now. We here present a patient with a germ cell tumor arising in the retroperitoneum, invading the prostate, which was successfully treated by a combination of chemotherapy and nonmutilating surgery. 相似文献
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Chakkalakal DA Strates BS Garvin KL Novak JR Fritz ED Mollner TJ McGuire MH 《Tissue engineering》2001,7(2):161-177
Experimental models were created in rat fibula to represent impaired bone healing so that biological deficiencies that cause bone repair to fail or to be delayed may be investigated. These models consist of a 4-mm-long segmental defect, created in rat fibula by osteotomy, and fitted with a 7-mm-long tubular specimen of demineralized bone matrix (DBM) over the cut ends of the fibula. The experiments in this study involved various modifications of the DBM scaffold designed to reduce its osteoinductive activity: steam sterilization (sDBM), ethylene oxide sterilization (eoDBM), trypsin digestion (tDBM), and guanidine hydrochloride extraction (gDBM). Bone healing was evaluated by bending rigidity of the fibula and mineral content of the repair site at 7 weeks post-surgery. The sDBM scaffolds resorbed completely by 7 weeks and hence this model was a nonhealing negative control. Rigidities in the unmodified DBM and tDBM groups were comparable, whereas in the gDBM and eoDBM groups it was significantly reduced. Histologically, in the 4-mm defects repaired with unmodified DBM, direct and endochondral bone formation in the scaffold and the defect resulted in a neocortex consisting of woven and lamellar bone uniting the broken bone by 7 weeks post-surgery. We conclude that the eoDBM and gDBM groups represent failure or delay of the bone repair process when compared with the unmodified DBM group in which the process is analogous to normal bone healing. 相似文献
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MR imaging of the male pelvis 总被引:2,自引:0,他引:2
Barentsz JO Engelbrecht MR Witjes JA de la Rosette JJ van der Graaf M 《European radiology》1999,9(9):1722-1736
Prostate and urinary bladder cancer are the most frequently encountered malignancies of the urinary tract. Appropriate use
of the different imaging techniques is crucial for accurate assessment of prognosis and for the development of appropriate
treatment planning. Especially determination of local tumor extension and detection of nodal or bone metastases is extremely
important. In this regard MR imaging is the most promising imaging technique. Therefore, in this review its role in staging
these malignancies is evaluated and compared with clinical staging, and other imaging techniques. Finally, future developments,
such as new sequences, new contrast agents, the role of surface coils and MR-guided biopsy, are considered. Also, the preferred
radiological approach is discussed. 相似文献
8.
Wim P.J. Witjes Michel J. A.M. De Wildt Peter F.W.M. Rosier Christine T.M. Caris Frans M.J. Debruyne Jean J.M.C.H. De La Rosette 《The Journal of urology》1996,156(3):1026-1034
Purpose
We quantified the physiological variability of clinical and pressure-flow study variables in patients with symptomatic benign prostatic enlargement.Materials and Methods
Symptom scores were measured, and advanced urodynamic studies with pressure-flow analysis were performed in 178 patients before and 6 months after a period of watchful waiting.Results
Patients without bladder outlet obstruction experienced significant symptomatic improvement. Symptoms in patients with obvious bladder outlet obstruction did not improve significantly. The reproducibility of mean pressure-flow variables was evident. However, there was an important intra-individual variability. Patients with obvious bladder outlet obstruction showed a significant decrease in detrusor pressure at maximal flow of 14 cm. water, a significant decrease in the urethral resistance factor of 7 cm. water and a significant decrease of 1 obstruction class on the linear passive urethral resistance relation nomogram, indicating less severe bladder outlet obstruction.Conclusions
Mean differences among therapy groups must be regarded critically, especially when the differences are slight and possibly within physiological variability. 相似文献9.
K. Ezz El Din W.F.R.M. Koch M.J. A.M. de Wildt L.A.L.M. Kiemeney F.M.J. Debruyne J.J.M.C.H. de la Rosette 《The Journal of urology》1996,155(6):1959-1964
Purpose
The reliability of the International Prostate Symptom Score (I-PSS) was tested in patients with lower urinary tract symptoms and/or benign prostatic hyperplasia.Materials and Methods
A total of 71 consecutive men with benign prostatic hyperplasia and/or lower urinary tract symptoms was asked to complete the I-PSS at baseline and 8 weeks later. At the second visit the physician also completed the I-PSS according to the complaints of the patient. Variability between both scores was evaluated by calculation of duplo errors and results were compared to the clinical data.Results
A considerable variability existed between the I-PSS results obtained at baseline and 8 weeks. The duplo error was 4.3. In a regression analysis of I-PSS, including all clinical parameters, only free flow had some predictive value for I-PSS outcomes.Conclusions
It is important to consider the variability of the I-PSS score when making decisions concerning treatment. 相似文献10.
Wim P.J. Witjes Peter F.W.M. Rosier Michel J. A.M. de Wildt Matheus P. van Iersel Frans M.J. Debruyne Jean J.M.C.H. de la Rosette 《The Journal of urology》1996,155(4):1317-1323