全文获取类型
收费全文 | 267735篇 |
免费 | 40710篇 |
国内免费 | 1687篇 |
专业分类
耳鼻咽喉 | 4738篇 |
儿科学 | 7284篇 |
妇产科学 | 5658篇 |
基础医学 | 25152篇 |
口腔科学 | 8414篇 |
临床医学 | 42448篇 |
内科学 | 60651篇 |
皮肤病学 | 5933篇 |
神经病学 | 29175篇 |
特种医学 | 9587篇 |
外国民族医学 | 13篇 |
外科学 | 43100篇 |
综合类 | 2450篇 |
现状与发展 | 43篇 |
一般理论 | 201篇 |
预防医学 | 25947篇 |
眼科学 | 6748篇 |
药学 | 12409篇 |
中国医学 | 208篇 |
肿瘤学 | 19973篇 |
出版年
2023年 | 5499篇 |
2022年 | 2001篇 |
2021年 | 5398篇 |
2020年 | 6838篇 |
2019年 | 4723篇 |
2018年 | 9930篇 |
2017年 | 9455篇 |
2016年 | 10369篇 |
2015年 | 11039篇 |
2014年 | 14989篇 |
2013年 | 19286篇 |
2012年 | 14645篇 |
2011年 | 15253篇 |
2010年 | 13179篇 |
2009年 | 14814篇 |
2008年 | 14595篇 |
2007年 | 14345篇 |
2006年 | 14979篇 |
2005年 | 13954篇 |
2004年 | 12758篇 |
2003年 | 11970篇 |
2002年 | 11520篇 |
2001年 | 3241篇 |
2000年 | 2236篇 |
1999年 | 3200篇 |
1998年 | 4283篇 |
1997年 | 3790篇 |
1996年 | 3555篇 |
1995年 | 3166篇 |
1994年 | 2452篇 |
1993年 | 2235篇 |
1992年 | 1756篇 |
1991年 | 1567篇 |
1990年 | 1353篇 |
1989年 | 1329篇 |
1988年 | 1315篇 |
1987年 | 1094篇 |
1986年 | 1160篇 |
1985年 | 1199篇 |
1984年 | 1478篇 |
1983年 | 1462篇 |
1982年 | 1848篇 |
1981年 | 1697篇 |
1980年 | 1535篇 |
1979年 | 863篇 |
1978年 | 1039篇 |
1977年 | 925篇 |
1976年 | 800篇 |
1975年 | 641篇 |
1974年 | 673篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Objective
The aim of the study was to estimate the effect of the state-based reinsurance programs through the section 1332 State Innovation Waivers on health insurance marketplace premiums and insurer participation.Data Source
2015 to 2022 Robert Wood Johnson Foundation Health Insurance Exchange Compare Datasets.Study Design
An event study difference-in-differences (DD) model separately for each year of implementation and a synthetic control method (SCM) are used to estimate year-by-year effects following program implementation.Data Collection/Extraction Methods
Not applicable.Principal Findings
Reinsurance programs were associated with a decline in premiums in the first year of implementation by 10%–13%, 5%–19%, and 11%–17% for bronze, silver, and gold plans (p < 0.05). There is a trend of sustained declines especially for states that implemented their programs in 2019 and 2020. The SCM analyses suggest some effect heterogeneity across states but also premium declines across most states. There is no evidence that reinsurance programs affected insurer participation.Conclusion
State-based reinsurance programs have the potential to improve the affordability of health insurance coverage. However, reinsurance programs do not appear to have had an effect on insurer participation, highlighting the need for policy makers to consider complementary strategies to encourage insurer participation. 相似文献2.
3.
4.
5.
6.
7.
8.
The Postoperative Short Course Content Study group 《Anaesthesia》2022,77(5):570-579
Most surgical and anaesthetic mortality and morbidity occurs postoperatively, disproportionately affecting low- and middle-income countries. Various short courses have been developed to improve patient outcomes in low- and middle-income countries, but none specifically to address postoperative care and complications. We aimed to identify key features of a proposed short-course addressing this topic using a Delphi process with low- and middle-income country anaesthesia providers trained as short-course facilitators. An initial questionnaire was co-developed from literature review and exploratory workshops to include 108 potential course features. Features included content; teaching method; appropriate participants; and appropriate faculty. Over three Delphi rounds (panellists numbered 86, 64 and 35 in successive cycles), panellists indicated which features they considered most important. Responses were analysed by geographical regions: Africa, the Americas, south-east Asia and Western Pacific. Ultimately, panellists identified 60, 40 and 54 core features for the proposed course in each region, respectively. There were high levels of consensus within regions on what constituted core course content, but not between regions. All panellists preferred the small group workshop teaching method irrespective of region. All regions considered anaesthetists to be key facilitators, while all agreed that both anaesthetists and operating theatre nurses were key participants. The African and Americas regional panels recommended more multidisciplinary healthcare professionals for participant roles. Faculty from high-income countries were not considered high priority. Our study highlights variability between geographical regions as to which course features were perceived as most locally relevant, supporting regional adaptation of short-course design rather than a one-size-fits-all model. 相似文献
9.
10.
Qian Zhang Larry D. Mesner Gina M. Calabrese Naomi Dirckx Zhu Li Angela Verardo Qian Yang Robert J. Tower Marie-Claude Faugere Charles R. Farber Thomas L. Clemens 《The Journal of clinical investigation》2021,131(7)
Bone mineral density (BMD) is a highly heritable predictor of osteoporotic fracture. GWAS have identified hundreds of loci influencing BMD, but few have been functionally analyzed. In this study, we show that SNPs within a BMD locus on chromosome 14q32.32 alter splicing and expression of PAR-1a/microtubule affinity regulating kinase 3 (MARK3), a conserved serine/threonine kinase known to regulate bioenergetics, cell division, and polarity. Mice lacking Mark3 either globally or selectively in osteoblasts have increased bone mass at maturity. RNA profiling from Mark3-deficient osteoblasts suggested changes in the expression of components of the Notch signaling pathway. Mark3-deficient osteoblasts exhibited greater matrix mineralization compared with controls that was accompanied by reduced Jag1/Hes1 expression and diminished downstream JNK signaling. Overexpression of Jag1 in Mark3-deficient osteoblasts both in vitro and in vivo normalized mineralization capacity and bone mass, respectively. Together, these findings reveal a mechanism whereby genetically regulated alterations in Mark3 expression perturb cell signaling in osteoblasts to influence bone mass. 相似文献