全文获取类型
收费全文 | 8701篇 |
免费 | 586篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 35篇 |
儿科学 | 199篇 |
妇产科学 | 122篇 |
基础医学 | 1062篇 |
口腔科学 | 106篇 |
临床医学 | 1367篇 |
内科学 | 1647篇 |
皮肤病学 | 61篇 |
神经病学 | 1002篇 |
特种医学 | 409篇 |
外科学 | 841篇 |
综合类 | 70篇 |
一般理论 | 3篇 |
预防医学 | 903篇 |
眼科学 | 115篇 |
药学 | 598篇 |
中国医学 | 64篇 |
肿瘤学 | 690篇 |
出版年
2023年 | 52篇 |
2022年 | 62篇 |
2021年 | 165篇 |
2020年 | 118篇 |
2019年 | 145篇 |
2018年 | 202篇 |
2017年 | 158篇 |
2016年 | 173篇 |
2015年 | 222篇 |
2014年 | 272篇 |
2013年 | 409篇 |
2012年 | 612篇 |
2011年 | 702篇 |
2010年 | 381篇 |
2009年 | 329篇 |
2008年 | 623篇 |
2007年 | 625篇 |
2006年 | 557篇 |
2005年 | 549篇 |
2004年 | 489篇 |
2003年 | 449篇 |
2002年 | 434篇 |
2001年 | 104篇 |
2000年 | 88篇 |
1999年 | 109篇 |
1998年 | 73篇 |
1997年 | 61篇 |
1996年 | 57篇 |
1995年 | 54篇 |
1994年 | 42篇 |
1993年 | 46篇 |
1992年 | 64篇 |
1991年 | 68篇 |
1990年 | 56篇 |
1989年 | 50篇 |
1988年 | 46篇 |
1987年 | 71篇 |
1986年 | 50篇 |
1985年 | 65篇 |
1984年 | 41篇 |
1983年 | 43篇 |
1982年 | 21篇 |
1981年 | 25篇 |
1980年 | 22篇 |
1979年 | 27篇 |
1978年 | 33篇 |
1977年 | 24篇 |
1976年 | 20篇 |
1971年 | 24篇 |
1970年 | 20篇 |
排序方式: 共有9294条查询结果,搜索用时 15 毫秒
1.
2.
Rob NM Weijers 《World journal of diabetes》2020,11(5):165-181
ResearchGate is a world wide web for scientists and researchers to share papers, ask and answer questions, and find collaborators. As one of the more than 15 million members, the author uploads research output and reads and responds to some of the questions raised, which are related to type 2 diabetes. In that way, he noticed a serious gap of knowledge of this disease among medical professionals over recent decades. The main aim of the current study is to remedy this situation through providing a comprehensive review on recent developments in biochemistry and molecular biology, which can be helpful for the scientific understanding of the molecular nature of type 2 diabetes. To fill up the shortcomings in the curricula of medical education, and to familiarize the medical community with a new concept of the onset of type 2 diabetes, items are discussed like: Insulin resistance, glucose effectiveness, insulin sensitivity, cell membranes, membrane flexibility, unsaturation index (UI; number of carbon-carbon double bonds per 100 acyl chains of membrane phospholipids), slow-down principle, effects of temperature acclimation on phospholipid membrane composition, free fatty acids, energy transport, onset of type 2 diabetes, metformin, and exercise. Based on the reviewed data, a new model is presented with proposed steps in the development of type 2 diabetes, a disease arising as a result of a hypothetical hereditary anomaly, which causes hyperthermia in and around the mitochondria. Hyperthermia is counterbalanced by the slow-down principle, which lowers the amount of carbon-carbon double bonds of membrane phospholipid acyl chains. The accompanying reduction in the UI lowers membrane flexibility, promotes a redistribution of the lateral pressure in cell membranes, and thereby reduces the glucose transporter protein pore diameter of the transmembrane glucose transport channel of all Class I GLUT proteins. These events will set up a reduction in transmembrane glucose transport. So, a new blood glucose regulation system, effective in type 2 diabetes and its prediabetic phase, is based on variations in the acyl composition of phospholipids and operates independent of changes in insulin and glucose concentration. UI assessment is currently arising as a promising analytical technology for a membrane flexibility analysis. An increase in mitochondrial heat production plays a pivotal role in the existence of this regulation system. 相似文献
3.
4.
5.
Alpha-melanocyte-stimulating hormone reduces endotoxin-induced liver inflammation. 总被引:6,自引:1,他引:5
下载免费PDF全文
![点击此处可从《The Journal of clinical investigation》网站下载免费的PDF全文](/ch/ext_images/free.gif)
H Chiao S Foster R Thomas J Lipton R A Star 《The Journal of clinical investigation》1996,97(9):2038-2044
Alpha-Melanocyte-stimulating hormone (MSH) is a potent anti-inflammatory agent in many models of inflammation, suggesting that it inhibits a critical step common to different forms of inflammation. We showed previously that alpha-MSH inhibits nitric oxide (NO) production in cultured macro-phages. To determine how alpha-MSH acts in vivo, we induced acute hepatic inflammation by administering endotoxin (LPS) to mice pretreated with Corynebacterium parvum, alpha-MSH prevented liver inflammation even when given 30 min after LPS administration. To determine the mechanisms of action of alpha-MSH, we tested its influence on NO, infiltrating inflammatory cells, cytokines, and chemokines. Alpha-MSH inhibited systemic NO production, hepatic neutrophil infiltration, and increased hepatic mRNA abundance for TNF alpha, and the neutrophil and monocyte chemokines (KC/IL-8 and MCP-1). We conclude that alpha-MSH prevents LPS-induced hepatic inflammation by inhibiting production of chemoattractant chemokines which then modulate infiltration of inflammatory cells. Thus, alpha-MSH has an effect very early in the inflammatory cascade. 相似文献
6.
Thomas J Birk Rodger D MacArthur Lynn M Lipton Sheldon D Levine 《The Journal of the Association of Nurses in AIDS Care》2002,13(6):20-24
The purpose of this study was to determine whether blood lipid and lipoprotein concentrations varied in 5 men with advanced HIV-1 infection after 12 months of aerobic exercise training. Prior to exercise, the mean baseline cholesterol and high-density lipoprotein cholesterol (HDL-C) serum concentration were each lower, and mean baseline triglyceride concentration was higher compared to a healthy population norm. Consistent exercise training for 12 months failed to significantly (p > .05) alter cholesterol or HDL-C. Triglyceride concentration was significantly (p < .05) elevated above baseline (63 mg/dL) regardless of exercise compliance. The results suggest that long-term exercise training cannot correct lipid profile abnormality, particularly hypertriglyceridemia, common to individuals with advanced HIV-1 infection. 相似文献
7.
Seymour Solomon Brian M Grosberg Deborah I Friedman Richard B Lipton 《Journal of neuro-ophthalmology》2007,27(3):243-4; author reply 244-5
8.
9.
Carel Bron Michel Wensing Jo LM Franssen Rob AB Oostendorp 《BMC musculoskeletal disorders》2007,8(1):107
Background
Shoulder disorders are a common health problem in western societies. Several treatment protocols have been developed for the clinical management of persons with shoulder pain. However available evidence does not support any protocol as being superior over others. Systematic reviews provide some evidence that certain physical therapy interventions (i.e. supervised exercises and mobilisation) are effective in particular shoulder disorders (i.e. rotator cuff disorders, mixed shoulder disorders and adhesive capsulitis), but there is an ongoing need for high quality trials of physical therapy interventions. Usually, physical therapy consists of active exercises intended to strengthen the shoulder muscles as stabilizers of the glenohumeral joint or perform mobilisations to improve restricted mobility of the glenohumeral or adjacent joints (shoulder girdle). It is generally accepted that a-traumatic shoulder problems are the result of impingement of the subacromial structures, such as the bursa or rotator cuff tendons. Myofascial trigger points (MTrPs) in shoulder muscles may also lead to a complex of symptoms that are often seen in patients diagnosed with subacromial impingement or rotator cuff tendinopathy. Little is known about the treatment of MTrPs in patients with shoulder disorders. 相似文献10.