全文获取类型
收费全文 | 4224篇 |
免费 | 327篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 46篇 |
儿科学 | 134篇 |
妇产科学 | 120篇 |
基础医学 | 634篇 |
口腔科学 | 144篇 |
临床医学 | 381篇 |
内科学 | 1063篇 |
皮肤病学 | 85篇 |
神经病学 | 304篇 |
特种医学 | 152篇 |
外科学 | 403篇 |
综合类 | 46篇 |
预防医学 | 393篇 |
眼科学 | 47篇 |
药学 | 206篇 |
中国医学 | 19篇 |
肿瘤学 | 385篇 |
出版年
2023年 | 29篇 |
2022年 | 53篇 |
2021年 | 90篇 |
2020年 | 53篇 |
2019年 | 104篇 |
2018年 | 94篇 |
2017年 | 83篇 |
2016年 | 96篇 |
2015年 | 117篇 |
2014年 | 163篇 |
2013年 | 156篇 |
2012年 | 234篇 |
2011年 | 227篇 |
2010年 | 141篇 |
2009年 | 133篇 |
2008年 | 188篇 |
2007年 | 207篇 |
2006年 | 212篇 |
2005年 | 200篇 |
2004年 | 175篇 |
2003年 | 206篇 |
2002年 | 174篇 |
2001年 | 126篇 |
2000年 | 153篇 |
1999年 | 107篇 |
1998年 | 65篇 |
1997年 | 55篇 |
1996年 | 40篇 |
1995年 | 48篇 |
1994年 | 28篇 |
1993年 | 42篇 |
1992年 | 85篇 |
1991年 | 72篇 |
1990年 | 57篇 |
1989年 | 65篇 |
1988年 | 51篇 |
1987年 | 41篇 |
1986年 | 51篇 |
1985年 | 43篇 |
1984年 | 29篇 |
1983年 | 23篇 |
1982年 | 20篇 |
1980年 | 17篇 |
1979年 | 15篇 |
1978年 | 14篇 |
1976年 | 17篇 |
1975年 | 12篇 |
1970年 | 16篇 |
1967年 | 12篇 |
1966年 | 13篇 |
排序方式: 共有4562条查询结果,搜索用时 15 毫秒
1.
Adjuvant irradiation is the standard treatment after breast conservative surgery. Normofractionated regimen with an overall treatment time of 5 to 6 weeks is often considered as a limiting factor for irradiation compliance. In order to answer this issue, moderate and more recently extreme hypofractionated protocols appeared. We report here oncological outcomes and toxicity of hypofractionated breast irradiation. After defining the frame of moderate and extreme hypofractionated breast irradiations based on overall treatment time, patient selection criteria were listed. According to their levels of proof, the results of moderate and extreme hypofractionated breast irradiation were analysed. Overall treatment time for moderate hypofractionated breast irradiation ranged from 3 to 4 weeks, while for extreme hypofractionated breast irradiation, it was less than 1 week. For moderate hypofractionated breast irradiation, whole breast irradiation was currently performed with or without lymph node irradiation. Moderate hypofractionated breast irradiation has proven to be as safe and as efficient as normofractionated breast irradiation with level IA evidence. For extreme hypofractionated breast irradiation, phase III randomized trials confirmed that accelerated partial breast irradiation was non-inferior in terms of local control compared to normofractionated whole breast irradiation (with external beam radiation therapy and multicatheter brachytherapy), with similar acute and late toxicity. While the use of intraoperative breast irradiation remains under debate, new very accelerated partial breast irradiation (overall treatment time not exceeding 2 days) protocols emerged with encouraging results. Accelerated partial breast irradiation is warranted for extreme hypofractionated breast irradiation and is indicated for low-risk breast cancers. Moderate and extreme hypofractionated breast irradiation regimens are validated and can be routinely proposed according to patient selection criteria. 相似文献
2.
3.
Alexander Stoff MD ; Angel A. Rivera PhD ; N. S. Banerjee PhD ; J. Michael Mathis PhD ; Antonio Espinosa-de-los-Monteros MD ; Long P. Le PhD ; Jorge I. De la Torre MD ; Luis O. Vasconez MD ; Thomas R. Broker PhD ; Dirk F. Richter MD ; Mariam A. Stoff-Khalili MD ; David T. Curiel MD PhD 《Wound repair and regeneration》2006,14(5):608-617
Genetically modified keratinocytes and fibroblasts are suitable for delivery of therapeutic genes capable of modifying the wound healing process. However, efficient gene delivery is a prerequisite for successful gene therapy of wounds. Whereas adenoviral vectors (Ads) exhibit superior levels of in vivo gene transfer, their transductional efficiency to cells resident within wounds may nonetheless be suboptimal, due to deficiency of the primary adenovirus receptor, coxsackie-adenovirus receptor (CAR). We explored CAR-independent transduction to fibroblasts and keratinocytes using a panel of CAR-independent fiber-modified Ads to determine enhancement of infectivity. These fiber-modified adenoviral vectors included Ad 3 knob (Ad5/3), canine Ad serotype 2 knob (Ad5CAV-2), RGD (Ad5.RGD), polylysine (Ad5.pK7), or both RGD and polylysine (Ad5.RGD.pK7). To evaluate whether transduction efficiencies of the fiber-modified adenoviral vectors correlated with the expression of their putative receptors on keratinocytes and fibroblasts, we analyzed the mRNA levels of CAR, alpha upsilon integrin, syndecan-1, and glypican-1 using quantitative polymerase chain reaction. Analysis of luciferase and green fluorescent protein transgene expression showed superior transduction efficiency of Ad5.pK7 in keratinocytes and Ad5.RGD.pK7 in fibroblasts. mRNA expression of alpha upsilon integrin, syndecan-1 and glypican-1 was significantly higher in primary fibroblasts than CAR. In keratinocytes, syndecan-1 expression was significantly higher than all the other receptors tested. Significant infectivity enhancement was achieved in keratinocytes and fibroblasts using fiber-modified adenoviral vectors. These strategies to enhance infectivity may help to achieve higher clinical efficacy of wound gene therapy. 相似文献
4.
5.
Antonio Rivera Antonio Yáñez Gloria León-Tello Constantino Gil Silvia Giono Eduardo Barba Lilia Cedillo 《BMC musculoskeletal disorders》2002,3(1):15-7
Background
Mycoplasma fermentans has been associated with rheumatoid arthritis. Recently, it was detected in the joints and blood of patients with rheumatoid arthritis, but it is not clear yet how the bacteria enter the body and reach the joints. The purpose of this study was to determine the ability of M. fermentans to induce experimental arthritis in rabbits following inoculation of the bacteria in the trachea and knee joints. 相似文献6.
Hysterosalpingography was performed in 31 patients by means of a low-dose scanning-beam digital radiographic system. The technique permits adequate evaluation of gynecologic abnormalities while allowing significant reduction in radiation: 2.4-mR (6.1 X 10(-7) C/kg) exposure to the skin and 0.7-mrad (7 X 10(-6) Gy) mean dose to the ovaries per image obtained. Sixteen patients demonstrated readily recognizable and documented abnormalities, corroborated by laparoscopy, laparotomy, or other supportive evidence. 相似文献
7.
8.
Gastrojejunostomy stricture after Roux-en-Y gastric bypass occurs in 3 to 27% of morbidly obese patients in the USA. We questioned
whether preoperative patient characteristics, including demographic attributes and comorbid disease, might be significant
factors in the etiology of stricture. In this study from November 2001 to February 2006 (51 months), at a high-volume bariatric
center, of the 1,351 patients who underwent laparoscopic gastric bypass, 92 developed stricture (6.8%). All but two were treated
successfully by endoscopic dilation. All patients stopped nonsteroidal anti-inflammatory medications 2 weeks prior to surgery
and did not restart them. The operative procedure included the use of a 21-mm transoral circular stapler to create the gastrojejunostomy;
the Roux limb was brought retrogastric, retrocolic. In an effort to reduce our center’s stricture rate, late in the study,
U-clips used at the gastrojejunostomy were replaced by absorbable sutures, and postoperative H2 antagonists were added to the treatment protocol. The change to absorbable polyglactin suture proved to be significant, resulting
in a lower stricture rate. The addition of H2 antagonists showed no significant effect. Following the retrospective review of the prospective database, univariate and
multivariate logistic regression analyses identified factors associated with the development of stricture. Gastroesophageal
reflux disease and age were each shown to be statistically significant independent predictors of stricture following laparoscopic
gastric bypass.
Presented at the 2006 Annual Meeting of the Society for Surgery of the Alimentary Tract, May 20–24, Los Angeles, CA (poster
presentation). 相似文献
9.
10.
Microbiology of adult cellulitis 总被引:1,自引:0,他引:1
D M Lutomski A T Trott J M Runyon C I Miyagawa J L Staneck J O Rivera 《The Journal of family practice》1988,26(1):45-48
Needle aspiration of cellulitis sites is commonly advocated to assist in the identification of causative organisms. Twenty-five nondiabetic, adult patients with a clinical diagnosis of cellulitis had site aspirations and blood cultures obtained before antibiotic therapy was initiated. Site cultures were positive in 6 of 25 patients. Blood cultures were positive in 4 of 25 patients. All organisms except one (Enterobacter agglomerans) were staphylococci or streptococci. The gram-negative bacilli were not believed to be a pathogen based on the patient's prompt response to nafcillin. In adult patients who do not have complications, the use of needle aspiration was not supported. Empiric treatment of cellulitis aimed at gram-positive cocci appears to be sufficient. 相似文献