全文获取类型
收费全文 | 4850篇 |
免费 | 474篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 34篇 |
儿科学 | 186篇 |
妇产科学 | 115篇 |
基础医学 | 589篇 |
口腔科学 | 192篇 |
临床医学 | 400篇 |
内科学 | 950篇 |
皮肤病学 | 70篇 |
神经病学 | 357篇 |
特种医学 | 140篇 |
外国民族医学 | 5篇 |
外科学 | 652篇 |
综合类 | 87篇 |
一般理论 | 2篇 |
预防医学 | 748篇 |
眼科学 | 221篇 |
药学 | 382篇 |
中国医学 | 7篇 |
肿瘤学 | 199篇 |
出版年
2023年 | 39篇 |
2021年 | 74篇 |
2020年 | 41篇 |
2019年 | 62篇 |
2018年 | 82篇 |
2017年 | 44篇 |
2016年 | 81篇 |
2015年 | 78篇 |
2014年 | 112篇 |
2013年 | 214篇 |
2012年 | 257篇 |
2011年 | 242篇 |
2010年 | 128篇 |
2009年 | 124篇 |
2008年 | 219篇 |
2007年 | 261篇 |
2006年 | 272篇 |
2005年 | 283篇 |
2004年 | 265篇 |
2003年 | 256篇 |
2002年 | 223篇 |
2001年 | 55篇 |
2000年 | 43篇 |
1999年 | 49篇 |
1998年 | 68篇 |
1997年 | 57篇 |
1995年 | 44篇 |
1994年 | 35篇 |
1993年 | 44篇 |
1992年 | 30篇 |
1991年 | 28篇 |
1990年 | 42篇 |
1989年 | 37篇 |
1988年 | 37篇 |
1987年 | 36篇 |
1986年 | 41篇 |
1985年 | 52篇 |
1984年 | 49篇 |
1983年 | 41篇 |
1982年 | 65篇 |
1981年 | 55篇 |
1980年 | 57篇 |
1979年 | 34篇 |
1978年 | 53篇 |
1977年 | 57篇 |
1976年 | 46篇 |
1975年 | 40篇 |
1974年 | 31篇 |
1973年 | 30篇 |
1969年 | 28篇 |
排序方式: 共有5336条查询结果,搜索用时 15 毫秒
1.
Osric A. Forrest Daniel M. Chopyk Yael Gernez Milton R. Brown Carol K. Conrad Richard B. Moss Vin Tangpricha Limin Peng Rabindra Tirouvanziam 《Journal of cystic fibrosis》2019,18(1):64-70
Background
Resistin is an immunometabolic mediator that is elevated in several inflammatory disorders. A ligand for Toll-like receptor 4, resistin modulates the recruitment and activation of myeloid cells, notably neutrophils. Neutrophils are major drivers of cystic fibrosis (CF) lung disease, in part due to the release of human neutrophil elastase- and myeloperoxidase-rich primary granules, leading to tissue damage. Here we assessed the relationship of resistin to CF lung disease.Methods
Resistin levels were measured in plasma and sputum from three retrospective CF cohorts spanning a wide range of disease. We also assessed the ability of neutrophils to secrete resistin upon activation in vitro. Finally, we constructed a multivariate model assessing the relationship between resistin levels and lung function.Results
Plasma resistin levels were only marginally higher in CF than in healthy control subjects. By contrast, sputum resistin levels were very high in CF, reaching 50–100 fold higher levels than in plasma. Among CF patients, higher plasma resistin levels were associated with allergic bronchopulmonary aspergillosis, and higher sputum resistin levels were associated with CF-related diabetes. Mechanistically, in vitro release of neutrophil primary granules was concomitant with resistin secretion. Overall, sputum resistin levels were negatively correlated with CF lung function, independently of other variables (age, sex, and genotype).Conclusions
Our data establish relationships between resistin levels in the plasma and sputum of CF patients that correlate with disease status, and identify resistin as a novel mechanistic link between neutrophilic inflammation and lung disease in CF. 相似文献2.
3.
Milton G. Mutchnick MD Horchang H. Lee MD 《Alcoholism, clinical and experimental research》1988,12(1):155-158
Concanavalin A-induced lymphocyte proliferation was studied in 25 patients with alcoholic hepatitis or compensated alcoholic cirrhosis. Nine alcoholics without evidence of liver disease were also evaluated. A nonlinear correlation equation, which was natural logarithmic, was applied to individual dose-response proliferation curves and permitted comparisons between patient groups and controls. The proliferative response in all patient groups was significantly lower when compared to healthy controls and was independent of the presence or absence of liver disease. This suggests that some changes in immune function observed in alcoholics may be linked to the direct effects of alcohol on the immune system rather than to the associated liver disease. 相似文献
4.
5.
6.
Hua Tan Jena Derrick Jin Hong Corneliu Sanda William M Grosse Howard J Edenberg Milton Taylor Scott Seiwert Lawrence M Blatt 《Journal of interferon & cytokine research》2005,25(10):632-649
A role for type II interferon (IFN-gamma) in resolving viral infection is suggested by the correlation of hepatitis C virus (HCV) clearance with enhancement of IFN-gamma-producing activated T cells in the resolution of acute HCV infection. Using vesicular stomatitis virus (VSV), a synergistic direct antiviral effect was documented using IFN-gamma1b and a potent, consensus type I IFN (IFN alfacon-1). Global expression profiling following EC50 exposure to IFN alfacon-1, IFN-gamma1b, or a cocktail of the two allowed the antiviral state to be correlated with induction of a subset of IFN-stimulated genes (ISGs). Genes identified through this analysis corresponded to classic antiviral components, ISGs more recently associated with direct antiviral functions, as well as expressed sequence tags (ESTs) and hypothetical proteins. The magnitude of these antiviral EC50-correlated expression events in human hepatoma (Huh7) cells exposed to clinically relevant doses of IFN alfacon-1, IFN-gamma1b, or a cocktail of the two was also probed because the standard of care for patients with chronic hepatitis C is type I IFN-containing regimens. Relative to type I IFNs used alone, the addition of type II IFN caused enhanced expression not only of many of the genes correlated with the direct antiviral state but also of genes involved in (1) antigen presentation to cytotoxic T lymphocytes (CTLs), (2) macrophage, natural killer (NK), and T helper 1 (Th1) cell recruitment and activation, (3) complement system function, (4) apoptosis, and (5) ISGs with unknown functions. As many of these processes are correlated clinically with resolution of chronic HCV infection, the combined use of these IFNs could display a beneficial effect on viral clearance in patients infected with HCV and other viruses through enhancement of one of these processes or of the direct antiviral state. 相似文献
7.
8.
Proposed Report on the Educational Qualifications of Sanitarians. Committe on Professional Education
9.
10.