全文获取类型
收费全文 | 2950篇 |
免费 | 289篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 162篇 |
妇产科学 | 42篇 |
基础医学 | 398篇 |
口腔科学 | 69篇 |
临床医学 | 460篇 |
内科学 | 603篇 |
皮肤病学 | 53篇 |
神经病学 | 183篇 |
特种医学 | 158篇 |
外科学 | 290篇 |
综合类 | 46篇 |
一般理论 | 1篇 |
预防医学 | 321篇 |
眼科学 | 42篇 |
药学 | 231篇 |
中国医学 | 3篇 |
肿瘤学 | 155篇 |
出版年
2021年 | 20篇 |
2020年 | 19篇 |
2019年 | 44篇 |
2018年 | 50篇 |
2017年 | 38篇 |
2016年 | 41篇 |
2015年 | 64篇 |
2014年 | 69篇 |
2013年 | 109篇 |
2012年 | 121篇 |
2011年 | 134篇 |
2010年 | 84篇 |
2009年 | 86篇 |
2008年 | 127篇 |
2007年 | 120篇 |
2006年 | 137篇 |
2005年 | 142篇 |
2004年 | 98篇 |
2003年 | 121篇 |
2002年 | 109篇 |
2001年 | 99篇 |
2000年 | 81篇 |
1999年 | 77篇 |
1998年 | 56篇 |
1997年 | 59篇 |
1996年 | 61篇 |
1995年 | 61篇 |
1994年 | 43篇 |
1993年 | 54篇 |
1992年 | 57篇 |
1991年 | 56篇 |
1990年 | 55篇 |
1989年 | 58篇 |
1988年 | 63篇 |
1987年 | 51篇 |
1986年 | 59篇 |
1985年 | 54篇 |
1984年 | 32篇 |
1983年 | 29篇 |
1982年 | 25篇 |
1981年 | 27篇 |
1980年 | 17篇 |
1979年 | 28篇 |
1978年 | 23篇 |
1977年 | 27篇 |
1976年 | 34篇 |
1975年 | 30篇 |
1974年 | 16篇 |
1973年 | 19篇 |
1970年 | 21篇 |
排序方式: 共有3240条查询结果,搜索用时 0 毫秒
1.
D Gröne† R Treudler† EM de Villiers‡ R Husak† CE Orfanos† ChC Zouboulis†§ 《Journal of the European Academy of Dermatology and Venereology》2006,20(2):202-205
Cidofovir is an acyclic nucleoside phosphonate with broad-spectrum activity against DNA viruses, including human papilloma virus (HPV). However, data on the efficacy of cidofovir in an immunosuppressive setting remain contradictory. We report for the first time on the promotion of the healing of recalcitrant warts in a patient with myelodysplastic syndrome with intravenous cidofovir treatment. 相似文献
2.
3.
4.
5.
Chondrons were isolated from human and canine osteoarthritic cartilage using low-speed homogenization techniques. Changes in chondron morphology were evaluated using differential interference-contrast microscopy, phase-contrast microscopy, and histochemical and ultrastructural methods. Chondrocyte viability was assessed using fluorescein diacetate staining, and chondron metabolism was investigated using autoradiography. The results suggest that initial changes in the collagen and proteoglycan distribution within the chondron are followed by chondrocyte proliferation to form clusters. These techniques offer the potential to study cell matrix interactions in degenerative osteoarthritis. 相似文献
6.
7.
8.
D C Poole 《Medicine and science in sports and exercise》1986,18(6):703-705
9.
Melissa Hurwitz Manuel G Garcia Robert L Poole John A Kerner 《Nutrition in clinical practice》2004,19(3):305-308
The standard of care for patients with cholestasis (direct bilirubin >or=2 mg/dL) while receiving parenteral nutrition (PN) solutions is to reduce or discontinue the copper and manganese. The repercussions of this action have not been studied. Two adult case reports document low serum copper levels associated with clinical symptoms of copper deficiency after the removal of copper from their PN solutions. We now describe the first known series of pediatric patients to develop copper deficiency after copper was removed from their PN solutions. 相似文献
10.
The receptor tyrosine kinase (RTK) Ret is activated by the formation of a complex consisting of ligands such as glial cell line-derived neurotrophic factor (GDNF) and glycerophosphatidylinositol-anchored coreceptors termed GFRalphas. During activation, Ret translocates into lipid rafts, which is critical for functional responses to GDNF. We found that Ret was rapidly ubiquitinated and degraded in sympathetic neurons when activated with GDNF, but, unlike other RTKs that are trafficked to lysosomes for degradation, Ret was degraded predominantly by the proteasome. After GDNF stimulation, the majority of ubiquitinated Ret was located outside of lipid rafts and Ret was lost predominantly from nonraft membrane domains. Consistent with the predominance of Ret degradation outside of rafts, disruption of lipid rafts in neurons did not alter either the GDNF-dependent ubiquitination or degradation of Ret. GDNF-mediated survival of sympathetic neurons was inhibited by lipid raft depletion, and this inhibitory effect of raft disruption on GDNF-mediated survival was reversed if Ret degradation was blocked via proteasome inhibition. Therefore, lipid rafts sequester Ret away from the degradation machinery located in nonraft membrane domains, such as Cbl family E3 ligases, thereby sustaining Ret signaling. 相似文献