全文获取类型
收费全文 | 1388篇 |
免费 | 75篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 15篇 |
妇产科学 | 27篇 |
基础医学 | 205篇 |
口腔科学 | 16篇 |
临床医学 | 204篇 |
内科学 | 355篇 |
皮肤病学 | 10篇 |
神经病学 | 96篇 |
特种医学 | 40篇 |
外科学 | 197篇 |
综合类 | 11篇 |
预防医学 | 41篇 |
眼科学 | 14篇 |
药学 | 109篇 |
肿瘤学 | 138篇 |
出版年
2023年 | 7篇 |
2022年 | 9篇 |
2021年 | 34篇 |
2020年 | 14篇 |
2019年 | 30篇 |
2018年 | 34篇 |
2017年 | 29篇 |
2016年 | 32篇 |
2015年 | 35篇 |
2014年 | 52篇 |
2013年 | 68篇 |
2012年 | 116篇 |
2011年 | 116篇 |
2010年 | 47篇 |
2009年 | 49篇 |
2008年 | 80篇 |
2007年 | 59篇 |
2006年 | 82篇 |
2005年 | 73篇 |
2004年 | 67篇 |
2003年 | 48篇 |
2002年 | 66篇 |
2001年 | 34篇 |
2000年 | 33篇 |
1999年 | 33篇 |
1998年 | 14篇 |
1997年 | 14篇 |
1996年 | 12篇 |
1995年 | 11篇 |
1994年 | 14篇 |
1993年 | 9篇 |
1992年 | 17篇 |
1991年 | 11篇 |
1990年 | 10篇 |
1989年 | 11篇 |
1988年 | 11篇 |
1987年 | 9篇 |
1986年 | 11篇 |
1985年 | 6篇 |
1984年 | 10篇 |
1983年 | 4篇 |
1980年 | 3篇 |
1979年 | 6篇 |
1976年 | 4篇 |
1975年 | 6篇 |
1974年 | 8篇 |
1973年 | 4篇 |
1972年 | 6篇 |
1971年 | 7篇 |
1970年 | 6篇 |
排序方式: 共有1480条查询结果,搜索用时 640 毫秒
1.
2.
J B Piera 《Phlébologie》1987,40(2):365-370
Vascular complications are frequent in paralyzing neurologic disorders, particularly in peripheral neurologic diseases: edema of the declive, cold feet, acrocyanosis, increased sudation. An enlarged leg in a paralyzed subject presenting frequently reduced sensitivity may indicate phlebitis, but also hematoma of an undetected fracture, or osteoarthropathy. Trophic disorders, such as edema, ulcerative hyperkeratosis and subcutaneous hematoma, are sometimes indicative of an unrecognized peripheral neuropathy, notably diabetic. Sclerous complications of venous impairment, or trophic disorders in algesic dystrophy, may result in incorrect diagnosis of a neurologic disorder. In practical therapeutic terms, it is necessary to emphasize the value of elastic retention, attentive pedicure and flexible and shock-absorbing footwear. 相似文献
3.
4.
5.
6.
7.
Di Biase AM Pietrantoni A Tinari A Siciliano R Valenti P Antonini G Seganti L Superti F 《Journal of medical virology》2003,69(4):495-502
Lactoferrin, a member of the transferrin family of approximately 80 kDa, consists of a single polypeptide chain folded in two symmetric, globular lobes (N- and C-lobes), each able to bind one ferric ion. This glycoprotein, found in physiological fluids of mammals, plays an important role in immune regulation and in defense mechanisms against bacteria, fungi, parasites, and viruses. Although the antiviral activity of lactoferrin is one of the major biological functions of such protein, the mechanism of action is still under debate. We have investigated both the role of tryptic fragments of bovine lactoferrin and the mechanism of lactoferrin antiviral effect toward adenovirus infection in HEp-2 cells. The results obtained demonstrated that the anti-adenovirus activity of lactoferrin is mediated by the N-terminal half of the protein as the N-lobe was able to inhibit adenovirus infection, even if at lower extent than undigested lactoferrin, whereas C-lobe was ineffective. The results also showed that the anti-adenovirus action of lactoferrin and of its N-terminal peptide lactoferricin took place on virus attachment to cell membrane, mainly through competition for common glycosaminoglycan receptors. The data provide evidence that the anti-adenovirus activity of lactoferrin is mediated mainly by the cluster of positive charges at the N-terminus of whole molecule and that the N-terminal peptide lactoferricin alone is sufficient to prevent infection. 相似文献
8.
Maristella?D'Uva Ida?Strina Antonio?Mollo Antonio?Ranieri Giuseppe?De Placido Pierpaolo?Di MiccoEmail author 《Journal of translational medicine》2005,3(1):43
Background
Antiphospholipid syndrome (APS) has been often associated to RPL since 1980 and some reports in the Literature rarely described antibodies to factor XII in patients with APS. 相似文献9.
Paradiso A Ranieri G Silvestris N Naccarato G Bevilacqua G Mangia A Leone B Vallejo C Simone G Schittulli F De Lena M 《Clinical and experimental medicine》2001,1(3):127-132
In the present study, the primary tumor angiogenesis characteristics of 81 stage IV previously untreated breast cancers with
synchronous metastasis to different distant sites (10 patients with soft tissue metastases, 31 with bone metastases, and 40
with visceral metastases) were analyzed. The primary intratumor microvessel density was assessed by immunohistochemical assay
on paraffin-embedded primary tumor samples, using a monoclonal anti-CD34 antibody. The mean primary intratumor microvessel
density (at 400× fields) was 78±39 (SD) microvessels per field. The microvessel density was not significantly related to the
main clinical/pathological features of the tumor (age, cytohistological grade, DNA ploidy, diameter, and receptor status).
The percentage of tumor cases with high primary intratumor microvessel density (cut-off median value of the series 73±39 microvessels/field)
did not significantly differ in patients with bone, soft tissue, or visceral metastatic disease. Aanalysis of clinical outcome
showed a significantly shorter time to progression and overall survival for patients with visceral metastases (P<0.001 and P<0.0002 by log-rank, respectively). Presence of visceral metastases was confirmed to be the only independent prognostic factor
related to a worse TTP (hazard risk 2.15, 95% confidence interval 1.14–4.03, P<0.02) and overall survival (hazard risk 1.81, 95% confidence interval 0.98–3.35, P<0.06) by multivariate analysis. In conclusion, the assessment of neoangiogenesis of primary breast cancer by CD34 expression
does not provide information predictive of different distant sites of metastasis.
Received: 15 June 2001 / Accepted: 12 September 2001 相似文献
10.
E. M. Wilson A. J. Ranieri Jr. O. L. Updike J. F. Dammann Jr. 《Medical & biological engineering & computing》1972,10(2):179-191
The thermal dilution method offers a number of advantages in the measurement of cardiac output particularly when measurements at frequent intervals over prolonged periods are required. The sources of error in the quantification of thermal indicator input and other factors pertinent to the applicability of this method to serial measurements in an automated clinical environment are discussed. 相似文献