全文获取类型
收费全文 | 770篇 |
免费 | 72篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 23篇 |
妇产科学 | 9篇 |
基础医学 | 92篇 |
口腔科学 | 17篇 |
临床医学 | 81篇 |
内科学 | 127篇 |
皮肤病学 | 7篇 |
神经病学 | 13篇 |
特种医学 | 254篇 |
外科学 | 55篇 |
综合类 | 6篇 |
预防医学 | 84篇 |
眼科学 | 7篇 |
药学 | 39篇 |
中国医学 | 1篇 |
肿瘤学 | 24篇 |
出版年
2021年 | 10篇 |
2020年 | 8篇 |
2019年 | 10篇 |
2018年 | 15篇 |
2017年 | 8篇 |
2016年 | 10篇 |
2015年 | 13篇 |
2014年 | 11篇 |
2013年 | 19篇 |
2012年 | 35篇 |
2011年 | 29篇 |
2010年 | 21篇 |
2009年 | 11篇 |
2008年 | 25篇 |
2007年 | 32篇 |
2006年 | 27篇 |
2005年 | 19篇 |
2004年 | 15篇 |
2003年 | 19篇 |
2002年 | 13篇 |
2001年 | 20篇 |
2000年 | 6篇 |
1999年 | 10篇 |
1998年 | 23篇 |
1997年 | 24篇 |
1996年 | 17篇 |
1995年 | 13篇 |
1994年 | 23篇 |
1993年 | 19篇 |
1992年 | 10篇 |
1991年 | 10篇 |
1990年 | 11篇 |
1989年 | 25篇 |
1988年 | 29篇 |
1987年 | 34篇 |
1986年 | 27篇 |
1985年 | 24篇 |
1984年 | 26篇 |
1983年 | 13篇 |
1982年 | 15篇 |
1981年 | 20篇 |
1980年 | 16篇 |
1979年 | 5篇 |
1978年 | 13篇 |
1977年 | 9篇 |
1976年 | 10篇 |
1975年 | 6篇 |
1974年 | 5篇 |
1972年 | 6篇 |
1968年 | 4篇 |
排序方式: 共有848条查询结果,搜索用时 78 毫秒
1.
2.
3.
Normal and diseased isolated lungs: high-resolution CT 总被引:8,自引:0,他引:8
4.
Picotamide inhibition of excess in vitro thromboxane B2 release by colorectal mucosa in inflammatory bowel disease. 总被引:1,自引:0,他引:1
Collins CE Benson MJ Burnham WR Rampton DS 《Alimentary pharmacology & therapeutics》1996,10(3):315-320
BACKGROUND: Inflammatory bowel disease is associated with increased mucosal release of eicosanoids. Among these, thromboxane A2 has been proposed as a possible inflammatory mediator; its suppression may be a useful therapeutic option. METHODS: Using a tissue incubation technique, we compared release of immunoreactive thromboxane B2 by colonic biopsies from patients with ulcerative colitis, Crohn's disease and controls, and assessed the inhibitory effect of picotamide, a thromboxane synthesis inhibitor-receptor antagonist, which has been widely used in Italy for management of ischaemic heart and cerebrovascular disease. RESULTS: Increased amounts of thromboxane B2 were released from biopsies from patients with active ulcerative colitis (median 238 pg/20 min/mg wet weight (interquartile range 147- 325), n = 12) and active Crohn's disease (252 (174-450), 6) compared with those from patients with quiescent ulcerative colitis (95 (61- 140), 12) or Crohn's disease (105 (57-201), 13), or controls (136 (64- 206), 8). Incubation with picotamide at concentrations between 100 microM and 1 mM reduced thromboxane B2 release (IC50 890 microM). CONCLUSION: Since increased thromboxane A2 production may have pathogenetic importance, thromboxane synthesis inhibitor-receptor antagonists such as picotamide merit therapeutic trial in the management of inflammatory bowel disease. 相似文献
5.
6.
7.
Hydrosalpinges adversely affect markers of endometrial receptivity 总被引:22,自引:10,他引:22
Meyer WR; Castelbaum AJ; Somkuti S; Sagoskin AW; Doyle M; Harris JE; Lessey BA 《Human reproduction (Oxford, England)》1997,12(7):1393-1398
While in-vitro fertilization (IVF) was initially developed in women with
tubal factor infertility, recent clinical studies have suggested that the
presence of hydrosalpinges lowers implantation and pregnancy rates. We
postulated that these hydrosalpinges cause impaired endometrial
receptivity. A total of 103 women with hydrosalpinges were prospectively
evaluated, and compared with 55 infertile and 44 fertile controls. All
women had endometrial biopsies during the window of implantation, analysed
by conventional histological criteria, and also stained for three integrin
markers of endometrial receptivity (alpha1beta1, alpha4beta1 and alpha
vbeta3). Women with hydrosalpinges (cases) expressed significantly less of
the alpha vbeta3 integrin compared with controls. There was no difference
in expression of alpha1beta1 or alpha4beta1 among groups. A significantly
greater number of cases had out of phase histology and missing alpha vbeta3
(type I defects) and absent integrin expression despite normal histological
maturation (type II) defects, compared with controls. Of 20 women with
impaired endometrial receptivity who were also biopsied after hydrosalpinx
surgery, 70% demonstrated increased alpha vbeta3 expression. Seventy-seven
percent of type I and 57% of type II defects were corrected
postoperatively. Using markers of endometrial receptivity, this study
demonstrates that inflammatory hydrosalpinges have an adverse effect on
endometrial receptivity, which in some cases may be overcome by surgical
treatment of the hydrosalpinx.
相似文献
8.
9.
10.
Care of diabetic patients in hospital clinics and general practice clinics: a study in Dudley.
下载免费PDF全文
![点击此处可从《The British journal of general practice》网站下载免费的PDF全文](/ch/ext_images/free.gif)
A five year retrospective casenote review was undertaken of 452 patients attending 11 different general practice diabetic clinics, and 506 patients attending a diabetic clinic at hospital A and 210 patients attending a diabetic clinic at hospital B. The populations attending the clinics, the degree of glycaemic control achieved and the monitoring for the development of diabetic complications were investigated. Insulin dependent patients comprised 57.9% of patients attending the diabetic clinic at hospital A, 35.7% at hospital B and 25.0% of patients attending the diabetic clinics at general practices. Of these 55.6%, 37.3% and 30.1% respectively received multiple daily insulin injections. Hospital A had a higher proportion of patients under 40 years old than hospital B or the general practice clinics. The ages of diabetic patients attending the general practice diabetic clinics were broadly similar to those attending hospital B. Significantly more general practice patients, both insulin and non-insulin dependent, had a mean blood glucose level of less than 11 mmol l-1 compared with patients attending clinics at hospitals A and B (P < 0.001). Glycosylated haemoglobin levels did not differ between patients attending hospital A and the general practice clinics. More non-insulin dependent and insulin dependent diabetic patients attending the general practice clinics and hospital A had been monitored satisfactorily for diabetic retinopathy (general practice clinic 68.8% and 39.7% respectively, hospital A 61.7% and 43.5%) than at hospital B (43.0% and 19.4%). Referral rates among all groups for ophthalmological assessment were similar.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献