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排序方式: 共有276条查询结果,搜索用时 15 毫秒
1.
Yildiz Oner-Iyido?an Pernur Oner Hikmet Ko?ak Abdul Lama Figen Gürd?l Selda? Bekpinar Nurettin Unur Zeynep Ozbek-Kir 《Pharmacological research》2005,52(4):340-345
Leukocyte arylsulphatase A (AS-A) was shown to be significantly high in newly-diagnosed breast cancer patients. Previous reports imply a connection between serum interleukin-6 (IL-6) and breast cancer, possibly through a modulation of enzymes involved in estrogen synthesis. Abnormal distribution of heparan sulphate proteoglycans (HSPGs) in malignant breast epithelial cells suggests that they play a key role in the regulation of cell growth. Estradiol is believed to be effective in modulating glycosaminoglycans (GAGs) and their depolymerizing enzymes. Therefore, in this study, attempts were made to evaluate the activity of leukocyte arylsulphatase A, serum interleukin-6, urinary GAGs and heparan sulphate (HS) in response to tamoxifen (TAM) therapy in mastectomised breast cancer patients. Thirty-four patients (aged 30-82 years) were administered TAM (20 mg twice daily). Blood and urine samples of each patient were collected three times (at the beginning, and in third and sixth month of TAM therapy), and biochemical parameters were measured. There was no difference between baseline leukocyte AS-A activity and that measured after three months. At the end of six months, enzyme activity was significantly higher than the former values (p=0.022), but within the reference intervals reported in the literature. Although this increase might imply a normalization, the duration of TAM therapy is not long enough to make a decision about either regression or aggravation of the disease. TAM did not have any effect on serum IL-6, urinary HS and GAG levels which may be due to insensitivity of these variables to TAM during the short period of therapy. Both urinary GAG and HS levels measured at sixth month exhibited a positive correlation with the baseline level of leukocyte AS-A (p=0.005 and 0.009, respectively), suggesting that positive responses to the drug might be seen in patients with low AS-A activity. 相似文献
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A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia 总被引:2,自引:0,他引:2
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Effect of water extract of Turkish propolis on tuberculosis infection in guinea-pigs. 总被引:2,自引:0,他引:2
Zeki Yildirim Süleyman Hacievliyagil Nurettin Onur Kutlu Nasuhi Engin Aydin Mine Kurkcuoglu Mustafa Iraz Riza Durmaz 《Pharmacological research》2004,49(3):287-292
Mycobacterium tuberculosis (H(37)R(v))-infected guinea-pig model was used to investigate the effect of water extract of propolis (WEP). After subcutaneous inoculation of tubercle bacilli, each animal received oral WEP (n=9), isoniazid (n=5) or saline (n=6) as placebo and were sacrificed 30 days later. Formation of necrosis was less prominent in the group treated with WEP, but was not statistically significant (P>0.05). The granuloma formation in the same group was more prominent than the placebo and isoniazid groups; however, this finding failed to reach statistical significance by the Kruskal-Wallis test (P>0.05). These findings suggest that Turkish WEP may have a limited effect on the development of tuberculosis infection in this guinea-pig model. 相似文献
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Vivek Pandey Simon Nurettin van Laarhoven Gaurav Arora Sripathi Rao 《Indian Journal of Orthopaedics》2014,48(4):432-434
Though rare, many anomalous origins of long head of the biceps tendon (LHBT) have been reported in the literature. Anatomic variations commonly explained are a third humeral head, anomalous insertion, congenital absence and adherence to the rotator cuff. We report a rare case who underwent shoulder arthroscopy with impingement symptoms where in LHBT was found to be bifurcated with a part attached to superior labrum and the other part to the posterior capsule of joint. Furthermore, intraarticular portion of LHBT was adherent to the undersurface of the supraspinatus tendon. Awareness of such an anatomical aberration during the shoulder arthroscopy is of great importance as it can potentially avoid unnecessary confusion and surgery. 相似文献
8.
Serdar Durdagi Timucin Avsar Muge Didem Orhan Muge Serhatli Bertan Koray Balcioglu Hasan Umit Ozturk Alisan Kayabolen Yuksel Cetin Seyma Aydinlik Tugba Bagci-Onder Saban Tekin Hasan Demirci Mustafa Guzel Atilla Akdemir Seyma Calis Lalehan Oktay Ilayda Tolu Yasar Enes Butun Ece Erdemoglu Alpsu Olkan Nurettin Tokay eyma Ik Aysenur Ozcan Elif Acar Sehriban Buyukkilic Yesim Yumak 《Molecular therapy》2022,30(2):963
Small molecule inhibitors have previously been investigated in different studies as possible therapeutics in the treatment of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). In the current drug repurposing study, we identified the leukotriene (D4) receptor antagonist montelukast as a novel agent that simultaneously targets two important drug targets of SARS-CoV-2. We initially demonstrated the dual inhibition profile of montelukast through multiscale molecular modeling studies. Next, we characterized its effect on both targets by different in vitro experiments including the enzyme (main protease) inhibition-based assay, surface plasmon resonance (SPR) spectroscopy, pseudovirus neutralization on HEK293T/hACE2+TMPRSS2, and virus neutralization assay using xCELLigence MP real-time cell analyzer. Our integrated in silico and in vitro results confirmed the dual potential effect of montelukast both on the main protease enzyme inhibition and virus entry into the host cell (spike/ACE2). The virus neutralization assay results showed that SARS-CoV-2 virus activity was delayed with montelukast for 20 h on the infected cells. The rapid use of new small molecules in the pandemic is very important today. Montelukast, whose pharmacokinetic and pharmacodynamic properties are very well characterized and has been widely used in the treatment of asthma since 1998, should urgently be completed in clinical phase studies and, if its effect is proved in clinical phase studies, it should be used against coronavirus disease 2019 (COVID-19). 相似文献
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We have previously reported that peroxynitrite (ONOO(-)) caused relaxations on isolated rat anococcygeus muscle and in the present study the possible mechanisms of the relaxant effect were investigated. ONOO(-) (0.03- 1.0 mmol/l)-induced relaxations were reduced significantly by the presence of an ATP-sensitive potassium channel (K(+)(ATP) channel) blocker, glibenclamide (0.3 micromol/l), or 1H-(1,2,4)oxadiazolo(4,3-alpha)quinoxalin-1-one (ODQ) (30.0 micromol/l), a guanylyl cyclase inhibitor. However, 3-aminobenzamide (3.0 mmol/l), an inhibitor of poly(ADP- ribose)synthase, did not influence the relaxant effect of ONOO(-) (1.0 mmol/l). Results of the present study implicate that activation of K(+)(ATP) channels and/or cGMP/K(+)(ATP) channel interaction might play a role in the relaxant responses to ONOO(-) in isolated rat anococcygeus muscle. 相似文献