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1.
Gennadi Naumov Elena Naumova Hilkka Turakainen Pirkko Suominen Matti Korhola 《Current genetics》1991,20(4):269-276
Summary We used a combination of genetic hybridization analysis and electrokaryotyping with radioactively labelled MEL1 gene probe hybridization to isolate and identify seven polymeric genes for the fermentation of melibiose in strain CBS 5378 of Saccharomyces cerevisiae (syn. norbensis). Four of the MEL genes, i.e. MEL3, MEL4, MEL6 and MEL7, were allelic to those found in S. cerevisiae strain CBS 4411 (syn. S. oleaginosus) whereas three genes, i.e. MEL8, MEL9 and MEL10 occupied new loci. Electrokaryotyping showed that all seven MEL genes in CBS 5378 were located on different chromosomes. The new MEL8, MEL9 and MEL10 genes were found on chromosomes XV, X/XIV and XII, respectively. 相似文献
2.
A. B. Poletaev V. V. Dergachev V. N. Shelikhov T. S. Naumova 《Bulletin of experimental biology and medicine》1977,83(2):152-154
A method of obtaining antineuronal and antiglial immune sera is described. The results of a quantitative immunochemical analysis of antigens of neuronal and glial fractions of rat brain are given. Neurons were shown to contain four, and glia three brain-specific proteins; in addition, one or two proteins are common to these cellular fractions.Department of Normal Physiology, Moscow Medical Stomatological Institute. Course of Physiology, Medico-Biological Faculty, N. I. Pirogov Second Moscow Medical Institute. (Presented by Academician of the Academy of Medical Sciences of the USSR N. A. Fedorov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 83, No. 2, pp. 156–158, February, 1977. 相似文献
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Mitochondrial DNA and Y-Chromosome Variation in the Caucasus 总被引:7,自引:3,他引:7
I. Nasidze E. Y. S. Ling D. Quinque I. Dupanloup R. Cordaux S. Rychkov O. Naumova O. Zhukova N. Sarraf-Zadegan G. A. Naderi S. Asgary S. Sardas D. D. Farhud T. Sarkisian C. Asadov A. Kerimov M. Stoneking 《Annals of human genetics》2004,68(3):205-221
We have analyzed mtDNA HVI sequences and Y chromosome haplogroups based on 11 binary markers in 371 individuals, from 11 populations in the Caucasus and the neighbouring countries of Turkey and Iran. Y chromosome haplogroup diversity in the Caucasus was almost as high as in Central Asia and the Near East, and significantly higher than in Europe. More than 27% of the variance in Y‐haplogroups can be attributed to differences between populations, whereas mtDNA showed much lower heterogeneity between populations (less then 5%), suggesting a strong influence of patrilocal social structure. Several groups from the highland region of the Caucasus exhibited low diversity and high differentiation for either or both genetic systems, reflecting enhanced genetic drift in these small, isolated populations. Overall, the Caucasus groups showed greater similarity with West Asian than with European groups for both genetic systems, although this similarity was much more pronounced for the Y chromosome than for mtDNA, suggesting that male‐mediated migrations from West Asia have influenced the genetic structure of Caucasus populations. 相似文献
5.
O. B. Naumova 《Bulletin of experimental biology and medicine》1976,82(6):1858-1860
The nature of Rec+ revertants isolated previously from cultures of recombinationally defective strainEscherichia
coli K-12 AB 2463 recA13 was studied. With the aid of phage P1 vira the chromosome region of the recA gene in cells of strain JC2915F- were transduced, after which the recombination capacity of the transductants was determined by crossing with JC158Hfr cells and their resistance to ultraviolet radiation was established. Sensitivity of the transductants to suppressor phages was determined. The Rec+ revertants were shown to differ with respect to the recA gene. In some Rec+ revertants the Rec+ phenotype appeared as the result of a back mutation in this gene from rec- to rec+, whereas in other revertants the Rec+ phenotype was due to indirect suppression.Department of Biology and General Genetics, Patrice Lumumba Peoples' Friendship University, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR V. M. Zhdanov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 82, No. 12, pp. 1487–1488, December, 1976. 相似文献
6.
Nine members, MEL2–MEL10, of the MEL gene family coding for -galactosidase were physically mapped to the ends of the chromosomes by chromosome fragmentation. Genetic mapping of the genes supported the location of all the MEL genes in the left arm of their resident chromosomes. 相似文献
7.
Ionic currents through batrachotoxin-modified sodium channels in frog nerve fibres were measured over a wide range of membrane potentials. At potentials above +80 mV currents decay in time and their steady-state level decreased as potentials increased. "Instantaneous" current measurements have shown that this phenomenon was due to the decrease in net channel conductance. Scorpion toxin affected current kinetics only slightly at these potentials, which suggested that these decays were not caused by usual inactivation process. Externally applied procaine induced slow (tens of ms) potential-dependent block of batrachotoxin-modified channels at large positive potentials. At large negative potentials (above -100 mV) "instantaneus" currents decreased due to fast voltage-dependent block of the channels by calcium ions. 相似文献
8.
Naumova LV 《Klinichna khirurhiia / Ministerstvo okhorony zdorov'ia Ukra?ny, Naukove tovarystvo khirurhiv Ukra?ny》2000,(5):11-13
In 45 patients with biliary calculous disease the relieving-dietetic therapy course was performed. The fragmentation or lysis of echopermeable echononsolid, echononpermeable echononsolid, echopermeable echosolid calculi was established. There was not noted fragmentation of echononpermeable echosolid calculi. 相似文献
9.
ObjectiveTo ascertain antimicrobial susceptibility profile of Proteus mirabilis (P. mirabilis) from clinical urine specimens at a university hospital in the spate of its recorded increasing resistance patterns.MethodsThe study was retrospective in nature. Data generated from urine cultures of patients at University of Calabar Teaching Hospital for a period of five years (2004–2009) were compiled. Relevant information obtained were age and gender of patients, organisms recovered and their antibiotic susceptibility patterns. P. mirabilis was identified using standard laboratory procedures.ResultsP. mirabilis showed the highest resistance against ampicillin, cloxacillin, amoxicillin, tetracycline, co-trimoxazole, erythromycin and chloramphenicol (100%–37.2%) while colistin, ofloxacin, ciprofloxacin, ceftriaxone, nalidixic acid and nitrofurantoin recorded the highest activity (59.1%–96.9%) with no drug recording 100% activity. The resistance of the nosocomial isolates of the organism were significantly higher than the community acquired isolates against that of the common antibiotics in use (P<0.05).ConclusionsExtreme caution should be exercised in antibiotic administration in hospital setting and the potential benefits adequately assessed while control of nosocomial infections be given a priority so as to limit the spread of resistant bacteria. 相似文献
10.