全文获取类型
收费全文 | 403篇 |
免费 | 30篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 10篇 |
妇产科学 | 2篇 |
基础医学 | 50篇 |
口腔科学 | 37篇 |
临床医学 | 40篇 |
内科学 | 71篇 |
皮肤病学 | 24篇 |
神经病学 | 15篇 |
特种医学 | 4篇 |
外科学 | 51篇 |
综合类 | 18篇 |
现状与发展 | 1篇 |
一般理论 | 3篇 |
预防医学 | 21篇 |
眼科学 | 3篇 |
药学 | 47篇 |
中国医学 | 1篇 |
肿瘤学 | 36篇 |
出版年
2023年 | 6篇 |
2022年 | 17篇 |
2021年 | 20篇 |
2020年 | 13篇 |
2019年 | 11篇 |
2018年 | 17篇 |
2017年 | 9篇 |
2016年 | 11篇 |
2015年 | 15篇 |
2014年 | 16篇 |
2013年 | 15篇 |
2012年 | 36篇 |
2011年 | 34篇 |
2010年 | 12篇 |
2009年 | 16篇 |
2008年 | 40篇 |
2007年 | 38篇 |
2006年 | 13篇 |
2005年 | 20篇 |
2004年 | 11篇 |
2003年 | 16篇 |
2002年 | 12篇 |
2001年 | 2篇 |
2000年 | 4篇 |
1999年 | 2篇 |
1998年 | 5篇 |
1997年 | 1篇 |
1995年 | 1篇 |
1993年 | 1篇 |
1992年 | 7篇 |
1991年 | 1篇 |
1990年 | 2篇 |
1986年 | 1篇 |
1984年 | 2篇 |
1983年 | 1篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1968年 | 1篇 |
1908年 | 1篇 |
1907年 | 1篇 |
排序方式: 共有435条查询结果,搜索用时 11 毫秒
1.
J. R. M. Copeland C. McWilliam M. E. Dewey D. Forshaw R. Shiwach R. T. Abed M. S. Muthu N. Wood 《International journal of geriatric psychiatry》1986,1(1):63-70
A random community sample of 1070 subjects aged over 65 was interviewed by trained non-medical interviewers using the Geriatric Mental State, community version (GMSA). A sub-sample of 126 subjects was selected so as to contain possible early cases of dementia, pseudo-dementia, and normal subjects; and re-interviewed, a mean 1 year and 23 weeks later, by a group of psychiatrists in training. The computer diagnosis AGECAT, based on GMSA applied by non-medical raters, had predicted at initial interview, nine out of twelve cases of dementia at follow-up and five out of nine borderline cases. An Organic/Depression Index may prove useful in predicting which of those cases with early organic levels will eventually develop dementia, depression or recover. 相似文献
2.
C. R. Thambi Dorai V. Muthu Alhagi Ng Chee Eng Z. Ismail A. Yakub 《Pediatric surgery international》1998,14(1-2):84-85
A neonate with severe respiratory distress due to a benign mediastinal teratoma (MT) is reported. Despite early and easy
surgical excision of the tumor, the child died due to poor cardiac function. Only ten cases of MT in neonates have been reported
in the literature so far. While the tumor has been known to interfere with lung development in utero, postnatal myocardial
dysfunction due to poor heart development has not been previously documented.
Accepted: 22 September 1997 相似文献
3.
Esaki Muthu Shankar Ramachandran Vignesh Kailapuri G Murugavel Pachamuthu Balakrishnan Ramalingam Sekar Charmaine AC Lloyd Suniti Solomon Nagalingeswaran Kumarasamy 《AIDS research and therapy》2007,4(1):1-7
Background
CD4+ T lymphocyte (CD4) cell count testing is the standard method for determining eligibility for antiretroviral therapy (ART), but is not widely available in sub-Saharan Africa. Total lymphocyte counts (TLCs) have not proven sufficiently accurate in identifying subjects with low CD4 counts. We developed clinical algorithms using TLCs, hemoglobin (Hb), and body mass index (BMI) to identify patients who require ART. 相似文献4.
A 60-year-old female developed a right parotid swelling six months after surgery for intra-oral squamous cell carcinoma. Fine needle aspiration (FNA) cytological smears showed dissociated large and small pleomorphic tumour cells with abundant mitoses and oncocytic features. A cytological diagnosis of parotid acinic cell carcinoma (ACC) was made. Histological study of the subtotal parotidectomy specimen showed a papillary cystic variety of acinic cell carcinoma (ACC-PCV). FNA cytological features in this case of ACC-PCV differs from the two previously reported cases in that it showed prominent oncocytic and high grade features and absence of papillary pattern in the cytological smears. ACC-PCV is an uncommon tumour and knowledge of its varied FNA cytological features is important for the diagnosis of this neoplasm. 相似文献
5.
6.
Deepa Shrestha Sahajal Dhooria Ganesh Kumar Munirathinam Inderpaul Singh Sehgal Kuruswamy Thurai Prasad Babu Ram Harkant Singh Ashutosh N. Aggarwal Goverdhan D Puri Valliappan Muthu Ritesh Agarwal 《Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders》2022,39(2)
7.
Antitumor effect of the angiogenesis inhibitor bevacizumab is dependent on susceptibility of tumors to hypoxia-induced apoptosis 总被引:11,自引:0,他引:11
Angiogenesis inhibition has been shown to enhance the therapeutic efficacy of cytotoxic chemotherapy in colorectal cancer. The basis of the contribution of this modality has not been defined fully. To determine the potential role of hypoxia-induced apoptosis, we studied a series of colon cancer cell lines with varying susceptibility to hypoxia. We exposed HT29 and HCT116 colon adenocarcinoma cell lines to sublethal periods of hypoxia three times weekly for 40 exposures, and derived cell lines both more resistant (from HT29) and more sensitive (from HCT116) to hypoxia-induced apoptosis. Both hypoxia-derived cell lines demonstrated more rapid growth than the parental lines when implanted subcutaneously in immunodeficient mice. Treatment of tumor-bearing mice with bevacizumab resulted in depletion of tumor microvasculature, upregulation of Hypoxia-inducible factor-1 alpha (HIF-1alpha), and increased pimonidazole staining, consistent with an anti-angiogenic effect and induction of hypoxia in tumors derived from all cell lines. The proportion of apoptotic cells was increased in all the treated tumors, and was most pronounced in the bevacizumab-treated HCT116-derived cells. The bevacizumab-treated tumors showed growth delay in HT29 and its derivative, and the parental HCT116. In the hypoxia-sensitive HCT116-derived tumors, marked tumor shrinkage and prolonged growth control occurred. Therefore, bevacizumab treatment is an effective inducer of a hypoxic environment, but the resulting cell kill and tumor shrinkage is determined by the susceptibility of the tumor to apoptosis. The induction of apoptosis by hypoxia may contribute to the benefits of such treatment in the clinical setting. 相似文献
8.
Saravana Kumar Jaganathan Muthu Vignesh Vellayappan Gayathri Narasimhan Eko Supriyanto 《World journal of gastroenterology : WJG》2014,20(16):4618-4625
Colorectal cancer is the second leading cause of cancer-related deaths in the United States.Recent studies prove that though chemotherapeutic agents are being used for the treatment of colon cancer,they become non-effective when the cancer progresses to an invasive stage.Since consumption of certain dietary agents has been linked with various cancers,fruit juices have been investigated for their consistently protective effect against colon cancer.The unique biochemical composition of fruit juices is responsible for their anticancer properties.In this review,the chemo-preventive effect of fruit juices such as pomegranate and citrus juices against colon cancer are discussed.For this purpose,the bioavailability,in vitro and in vivo effects of these fruit juices on colorectal cancer are highlighted.Moreover,there is a scarcity of studies involving human trials to estimate the preventive nature of these juices against colon cancer.This review will support the need for more preclinical tests with these crude juices and their constituents in different colorectal cancer cell lines and also some epidemiological studies in order to have a better understanding and promote pomegranate and citrus juices as crusaders against colon cancer. 相似文献
9.
Utility of recombinant Aspergillus fumigatus antigens in the diagnosis of allergic bronchopulmonary aspergillosis: A systematic review and diagnostic test accuracy meta‐analysis
下载免费PDF全文
![点击此处可从《Clinical and experimental allergy》网站下载免费的PDF全文](/ch/ext_images/free.gif)
10.