A case of pemphigus vulgaris possibly triggered by quinolones

Pemphigus vulgaris is an autoimmune blistering disorder in which both genetic and environmental factors, mainly drugs, are thought to play a part in its aetiopathogenesis. Although some drugs that contain thiol groups, such as D-penicillamine and captopril, and non-thiol drugs, such as cephalosporin, have been reported to trigger or induce pemphigus, there are no previous reports regarding the influence of quinolones in triggering this disease. Here we present a case of pemphigus possibly triggered by quinolones.     

HPLC和1HNMR分析确定cis-A-和cis-B-羟甲芬太尼的组成和构型

羟甲芬太尼(1)是一个强效的镇痛剂和高亲和、高选择性的阿片μ受体激动剂。通过HPLC和¹HNMR分析,cis-A-l被确定为由等量的cis-(+)-(3R,4S,2'S)-l和:cis-(—)-(3S,4R,2'R)-1组成的外消旋体,cis-B-l被确定为由等量的cis-(—)-(3R,4S,2'R)-1和cis-(+)-(3S/,4R,2'S)-1组成的外消旋体。     

佳贝和欧可芬滴眼液在白内障手术中应用的研究

目的：评价佳贝和欧可芬滴眼液在白内障术中维持瞳孔散大及术后抗炎作用疗效。胡机分组（佳贝组、欧可芬组和对照组）研究８６名白内障患者术前应用两种药物后,白内障术中瞳孔大小的改变以及对卡米可林（氨甲酰胆碱,Ｃａｒｂａｃｏｌ）缩瞳作用的影响;以地塞米松滴眼液为对照,研究应用两种滴眼液对术后角膜后ＫＰ和房水混浊度的影响,以及对术眼眼压的影响。结果：与对照组相比,佳贝和欧可芬都能有效抑制术中的瞳孔缩小（Ｐ〈０     

用二维核磁共振技术研究赤芝孢子内酯A和B的结构

通过~1H-~1H,~1H-~(13)C相关谱(COSY),~1H-~(13)C远程偶合相关谱(OOLOC)及NOE二维谱(NOESY)等新的二维核磁共振技术确定了两个新化合物赤芝孢子内酯A和B的结构。     

Liver transplantation in tyrosinaemia type 1: the dilemma of timing the operation

Four children with tyrosinaemia type 1 received liver transplants. The metabolic disorder was corrected and all four had normal liver function on an unrestricted diet. Two children, transplanted at age five and seven years, proved to have occult hepatocellular carcinoma and both subsequently developed pulmonary metastases. One child was well 32 months after removal of a single pulmonary metastasis but the other child died with multiple metastases. The two younger children, transplanted at age 19 and 21 months, were well 28 and 44 months after operation, one after a second liver transplant. Our experience confirms the high risk of hepatocellular carcinoma in this disease and the potential value of early liver transplantation.     

Massive Cystic Hepatomegaly in a Female Patient with Polycystic Kidney Disease Treated by Combined Hepatic and Renal Transplantation

A patient with cystic kidney disease of adult onset and severecystic hepatomegaly is presented. The patient was severely disabledsolely by her abdominal bulk. Simultaneous liver and renal transplantationwas undertaken successfully.     

宁夏地区住院回族糖尿病患者医疗费用影响因素15年对比分析

目的:观察宁夏地区回族糖尿病患者医疗费用分布情况,分析其影响因素。方法:①对1990-01-01/1994-12-31和2000-01-01/2004-12-31在宁夏回族自治区宁夏医学院附属医院和银川市第一人民医院内分泌科住院的回族糖尿病患者1434例病历资料进行分析,其中男827例,女607例,平均年龄(46±17)岁,平均病程(6.8±5.7)年。患者的直接医疗费用资料源自上述患者住院时的收费情况一览表。1990-01-01/1994-12-31收住此两家医院患者601例,其中合并慢性并发症、合并大血管并发症、合并微血管并发症患者占56.5%,55.4%,44.6%。2000-01-01/2004-12-31收住此两家医院患者833例,合并慢性并发症、合并大血管并发症、合并微血管并发症患者占74.3%,49.5%,50.4%。②依据中华医学会糖尿病分会统一制定的调查表格,对患者基本情况、本次入院情况以及医疗费用的情况等项目进行整理。结果:①有无并发症住院回族糖尿病患者住院费用对比:1990/1994无并发症和有并发症回族患者人均发生住院直接医疗费用分别为(1722±88)和(3002±98)元;在2000/2004相应医疗费用为(3151±118)和(6742±124)元。15年间无并症医疗费用增长率明显低于有并发症者[(83±14)%,(125±12)%,P<0.01]。②大、微血管并发症住院回族糖尿病患者住院费用对比:1990/1994伴有大血管和微血管并发症回族患者人均发生住院直接医疗费用分别为(3179±104)和(2760±145)元;2000/2004相应医疗费用分别为(8841±205)和(4676±105)元。15年间伴大血管并症患者医疗费用增长率明显高于微血管并发症患者[(177±15)%,(70±6)%,P<0.01]。③宁夏住院回族糖尿病患者不同系统并发症住院医疗费用分布情况:1990/1994合并心血管病变患者的住院医疗费用居首位[(3246±147)元],其次是合并脑血管并发症患者和肾脏病变、糖尿病足患者[(2996±144),(2965±128)元],周围神经病变患者医疗费用最低;2000/2004合并心血管病变患者住院医疗费用仍居首位[(10430±149)元],其次为合并肾脏病变和糖尿病足患者[(7039±178),(6188±158)元],周围神经病变患者医疗费用仍最低。结论:合并并发症为宁夏地区回族住院糖尿病患者医疗费用增长的主要因素,且大血管并发症影响最大。     

Serologic test for syphilis as a surrogate marker for human immunodeficiency virus infection among United States blood donors

BACKGROUND: This study evaluated the usefulness of the serologic test for syphilis (STS) in preventing the transmission of human immunodeficiency virus (HIV), hepatitis B and C viruses, and human T- lymphotropic virus via the transfusion of seronegative, infectious window-period blood. STUDY DESIGN AND METHODS: Demographic and laboratory information on blood donations made between January 1992 and June 1994 in 18 American Red Cross regions was analyzed. It was assumed that the same proportion of HIV-positive and HIV-infectious window- period donations reacted on STS and were negative on other screening tests (hepatitis B and C viruses and human T-lymphotropic virus). This proportion multiplied by the estimated number of HIV-infectious window- period donations is the number of post-screening HIV-infectious donations removed by STS. RESULTS: Of 4,468,570 donations, 12,145 (0.27%) were STS positive and 377 (0.008%) were HIV positive. Among donations that were negative on other screening tests, STS-reactive donations were 12 times more likely to be HIV positive (odds ratio = 11.9; 95% CI = 5,26). However, of an estimated 13 infectious window- period donations, 0.2 would have been removed because of a reactive STS, at a cost of over $16 million. CONCLUSION: STS is a poor marker and a costly strategy for preventing post-screening HIV infections and other blood-borne diseases.