Correlations between the pharmacokinetics and dynamics of pharmacological effects of bromantane

It is shown that there is a mathematical correlation between an integral characteristic of activity of the organism (the capacity for work), electrophysiological indexes of functioning of the brain structures, and the concentration of a novel derivative of 2-aminoadamantane, bromantane, in the brain. The nature of the correlation between integral characteristics of the organism studied on different levels is found to change depending on the time elapsed from the administration of the preparation and on its concentration in the blood or target tissue. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N ^o 3 pp. 305–308, March, 1995 Presented by M. D. Mashkovskii, Member of the Russian Academy of Medical Sciences     

Determination of subpopulations of T- and B-lymphocytes in human blood using an immunofluorescence method

The immunofluorescent technique for assaying T- and B-lymphocyte subpopulations, using monoclonal (OCT3, OCT4, OCT8) and monospecific antibodies is described. The results of immunocompetent cell determinations in normal subjects and in patients are presented. A conclusion is made that use of universal immunofluorescent method for assays of the lymphocyte subpopulations widens the possibilities of diagnosis of immunodeficiency states.     

The late examination results in children with pylorospasm and dyskinesia of the proximal sections of the small intestine]

The article analyses the late-term results of examination of 46 children with neurogenous dyskinesias of the gastrointestinal tract which were recognised in infancy for the first time. The author believes that the functional, motor-evacuation, and sphincter disorders of the proximal parts of the digestive tube lead to the development of organic noninfectious diseases of the gastroduodenal system.     

Synthesis and antihypoxic activity of 1,2,4-triazoles, 1,3-dithiane-1,1,3,3-tetraoxides,and 1,4-benzothiazin-3(4H)-one

Translated from Khimiko-farmatsevticheskii Zhurnal, Vol. 26, No. 2, pp. 38–41, February, 1992.     

Treatment of strictures of the urethra in men

Treatment of urethral strictures was conducted in 84 male patients, aged 15 to 78 years. Combined treatment included optical (retrograde and antegrade) urethrotomy and transurethral electroresection (TUR) of scar tissues, combined with postoperative endourethral phonophoresis with lidase (64 units) and an antibiotic. Retrograde urethrotomy was performed under visual control. Scar tissues were dissected layer by layer until the resectoscope could be introduced. Antegrade urethrotomy was performed after bougies were passed through the stricture. To improve the results of endourethral surgery, all patients underwent endourethral lidase and antibiotic phonophoresis, using "C" irradiator of the Soviet Sterzhen' device, on postoperative day 3. The duration of phonophoretic session was 6 to 12 min at 0.1-0.3 kW. There were 8 to 10 sessions to a course of physiotherapy. This combined treatment stabilized urodynamic parameters at 1 to 1.5 years' follow-up, as evidenced by significantly increased mean and peak urinary flow rate and shorter bladder evacuation time. There were basically no postoperative relapses in 92.1% of the patients.