The pharmacokinetics and metabolism of bonnecor in rats

The pharmacokinetics of 14C-bonnecor after intravenous and oral administration was studied. The bioavailability was 70%. It was shown that administration of doses in the range of from 3 to 43 mg/kg as well as the repeated use of bonnecor failed to influence the pharmacokinetic parameters.     

Born this Way–or Not? The Relationship Between Essentialism and Sexual Minorities’ LGBTQ+ Identification and Belonging

Archives of Sexual Behavior - Bisexual people experience lower levels of belonging in the LGBTQ+ community than gay and lesbian people. We investigated one of the factors that may reduce bisexual...     

Uptake of iodine-123-α-methyl tyrosine by gliomas and non-neoplastic brain lesions

Using single-photon emission tomography (SPET), the radiopharmaceuticall,-3-iodine-123--methyl tyrosine (IMT) has been applied to the imaging of amino acid transport into brain tumours. It was the aim of this study to investigate whether IMT SPET is capable of differentiating between high-grade gliomas, low-grade gliomas and non-neoplastic brain lesions. To this end, IMT uptake was determined in 53 patients using the triple-headed SPET camera MULTISPECT 3. Twenty-eight of these subjects suffered from high-grade gliomas (WHO grade III or IV), 12 from low-grade gliomas (WHO grade II), and 13 from non-neoplastic brain lesions, including lesions after effective therapy of a glioma (five cases), infarctions (four cases), inflammatory lesions (three cases) and traumatic haematoma (one case). IMT uptake was significantly higher in high-grade gliomas than in low-grade gliomas and non-neoplastic lesions. IMT uptake by low-grade gliomas was not significantly different from that by non-neoplastic lesions. Diagnostic sensitivity and specificity were 71% and 83% for differentiating high-grade from low-grade gliomas, 82% and 100% for distinguishing high-grade gliomas from non-neoplastic lesions, and 50% and 100% for discriminating low-grade gliomas from non-neoplastic lesions. Analogously to positron emission tomography with radioactively labelled amino acids and fluorine-18 deoxyglucose, IMT SPET may aid in differentiating high-grade gliomas from histologically benign brain tumours and non-neoplastic brain lesions; it is of only limited value in differentiating between non-neoplastic lesions and histologically benign brain tumours.     

Über den Glykogengehalt in Mundhöhlencarcinomen

Zusammenfassung Im Rahmen einer größeren Untersuchung über die Möglichkeiten einer Früherkennung bösartiger Tumoren in der Mundhöhle werden 22 verschiedene Mundhöhlencarcinome auf ihren Gehalt an Glykogen untersucht. Dabei ergibt sich gegenüber den Carcinomen der Portio uteri einrelativ hoher Prozentsatz glykogenhaltiger Carcinome. Vergleichsweise werden daneben die Glykogenverhältnisse der normalen menschlichen Mundschleimhaut an 432 Mundschleimhautexcisionen lebender Patienten histochemisch untersucht und ein unterschiedlicher Glykogengehalt in den einzelnen Mundhöhlenregionen aufgedeckt. Innerhallb der Epithelschichten bleibt das Stratum germinativum stets glykogenfrei. Vergleichende Untersuchungen an der glykogenfreien Mundschleimhaut von Ratten und Kaninchen konnten nachweisen, daß Teilungszellen zur Glykogensynthese nicht in der Lage sind. Zur Klärung der Frage, ob der Glykogengehalt innerhalb der Mundschleimhaut dem Insulin-Adrenalin-Regulator unterliegt, wurden darüber hinaus die Mundschleimhautverhältnisse mittels der Schillerschen Jodlösung an 1661 Diabetikern geprüft und die Mundschleimhautexcisionen von 32 Diabetikern histochemisch ausgewertet und zum jeweiligen Blutzuckerspiegel in Relation gesetzt. Die Ergebnisse sprechen dafür, daß der Glykogengehalt der Mundschleimhaut nicht vom Insulinspiegel abhängt. Da sich für Phosphorylierungsvorgänge Anhaltspunkte nicht ergaben, wird das Glykogen der Mundschleimhaut und der Mundhöhlencarcinome als Stapelungsglykogen angesprochen.     

Insurance and the dental consultant

This article attempts to familiarize the readers with types and functions of dental consultants. Included are suggested guidelines in the review of claims with helpful suggestions to expedite the claim-handling process. Emphasis is placed on traumatic claims rather than benefit claims.     

Untersuchungen über die Bindung von Diphtherietoxin-und Antitoxin,zugleich ein Beitrag zur Kenntniss der Constitution des Diphtheriegiftes

Ohne Zusammenfassung