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排序方式: 共有157条查询结果,搜索用时 15 毫秒
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The case of a health careers program evaluation illustrates some aspects of evaluating very small and rapidly evolving programs. Such programs can change quickly, since there is no massive bureaucracy to restrain them. Rigid evaluation research methods would frustrate both researchers and program staff. The authors suggest that flexible design, use of specialized interviewing and analytical experiments--in this case, telephone surveys testing program response--and a recognition that a consultative relationship exists will result in outcomes useful to the program and rich in evaluation data. 相似文献
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J M Morath 《Nursing management》1988,19(3):72-5, 78, 80
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Marina A. Morath Friederike Hörster Sven W. Sauer 《Pediatric nephrology (Berlin, Germany)》2013,28(2):227-235
Methylmalonic acidurias are a heterogeneous group of inborn errors of branched-chain amino acid metabolism. Depending on the underlying etiology, acute or chronic renal disease constitutes major (long-term) complications. In recent decades, overall survival has improved due to optimized treatment strategies based on the use of standardized emergency protocols and dialysis techniques. The majority of these patients, especially those having mut°, cblB, and cblA deficiency, are at increased risk of developing chronic kidney disease secondary to tubulointerstitial nephritis to require hemo- or peritoneal dialysis. Kidney and/or liver transplantation, as organ replacement, or even gene therapy on a limited scale, are controversially discussed treatment options in methylmalonic acidurias. The pathophysiological basis of renal disease has not been clarified in detail until now, but a severe mitochondrial dysfunction and an impairment of tubular dicarboxylic acid transport due to accumulated toxic metabolic compounds has been recently proposed. Another severe renal complication of methylmalonic acidurias is the occurrence of cblC-associated infantile atypical hemolytic syndrome, which can result in acute kidney injury. Close collaboration between (pediatric) nephrologists and metabolic specialists is required for the long-term management of these patients. 相似文献
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Blassmann Ute Morath Benedict Fischer Andreas Knoth Holger Hoppe-Tichy Torsten 《Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz》2018,61(9):1103-1110
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz - Arzneimittelbezogene Probleme (ABP) sind eine signifikante und häufig vermeidbare Ursache für Morbidität und... 相似文献
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Antje Wiesener Karl X. Knaup Maike Büttner‐Herold Anne Dieterle Johanna Stoeckert Bernhard Riedl Christian Morath Alexandra Wald Florian Vondran Felix Braun Johannes Schdel Markus Schueler Mario Schiffer Kerstin Amann Andr Reis Cornelia Kraus Michael S. Wiesener 《American journal of transplantation》2020,20(5):1410-1416
In light of the organ shortage, there is a great responsibility to assess postmortal organs for which procurement has been consented and to increase the life span of transplanted organs. The former responsibility has moved many centers to accept extended criteria organs. The latter responsibility requires an exact diagnosis and, if possible, omission of the harmful influence on the transplant. We report the course of a kidney transplant that showed a steady decline of function over a decade, displaying numerous cysts of different sizes. Clinical workup excluded the most frequent causes of chronic transplant failure. The filed allocation documents mentioned the donor’s disease of oral‐facial‐digital syndrome, a rare ciliopathy, which can also affect the kidney. Molecular diagnosis was performed by culturing donor tubular cells from the recipient´s urine more than 10 years after transplantation. Next‐generation panel sequencing with DNA from tubular urinary cells revealed a novel truncating mutation in OFD1, which sufficiently explains the features of the kidney transplants, also found in the second kidney allograft. Despite this severe donor disease, lifesaving transplantation with good long‐term outcome was enabled for 5 recipients. 相似文献
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Consensus on definition and severity grading of lymphatic complications after kidney transplantation
A. Mehrabi Y. Kulu M. Sabagh E. Khajeh S. Mohammadi O. Ghamarnejad M. Golriz C. Morath W. O. Bechstein G. A. Berlakovich N. Demartines M. Duran L. Fischer L. Gürke J. Klempnauer A. Königsrainer H. Lang U. P. Neumann A. Pascher A. Paul P. Pisarski J. Pratschke S. Schneeberger U. Settmacher R. Viebahn M. Wirth B. Wullich M. Zeier M. W. Büchler 《The British journal of surgery》2020,107(7):801-811
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