全文获取类型
收费全文 | 183篇 |
免费 | 8篇 |
国内免费 | 6篇 |
专业分类
儿科学 | 1篇 |
基础医学 | 19篇 |
口腔科学 | 2篇 |
临床医学 | 8篇 |
内科学 | 88篇 |
皮肤病学 | 1篇 |
神经病学 | 13篇 |
特种医学 | 2篇 |
外科学 | 24篇 |
预防医学 | 2篇 |
药学 | 8篇 |
肿瘤学 | 29篇 |
出版年
2023年 | 3篇 |
2022年 | 2篇 |
2021年 | 12篇 |
2020年 | 6篇 |
2019年 | 16篇 |
2018年 | 5篇 |
2017年 | 4篇 |
2016年 | 6篇 |
2015年 | 6篇 |
2014年 | 5篇 |
2013年 | 6篇 |
2012年 | 6篇 |
2011年 | 11篇 |
2010年 | 9篇 |
2009年 | 4篇 |
2008年 | 9篇 |
2007年 | 11篇 |
2006年 | 19篇 |
2005年 | 24篇 |
2004年 | 11篇 |
2003年 | 10篇 |
2002年 | 4篇 |
2000年 | 1篇 |
1999年 | 1篇 |
1998年 | 2篇 |
1991年 | 1篇 |
1979年 | 2篇 |
1977年 | 1篇 |
排序方式: 共有197条查询结果,搜索用时 15 毫秒
1.
2.
Masatsugu Ohara Goki Suda Megumi Kimura Osamu Maehara Tomoe Shimazaki Taku Shigesawa Kazuharu Suzuki Akihisa Nakamura Naoki Kawagishi Masato Nakai Takuya Sho Mitsuteru Natsuizaka Kenichi Morikawa Koji Ogawa Tomoe Kobayashi Minoru Uebayashi Ryo Takagi Isao Yokota Tsuyoshi Shimamura Naoya Sakamoto 《Hepatology research》2020,50(6):715-725
3.
Asada K Yoshiji H Noguchi R Ikenaka Y Kitade M Kaji K Yoshii J Yanase K Namisaki T Yamazaki M Tsujimoto T Akahane T Uemura M Fukui H 《International journal of molecular medicine》2007,20(5):725-729
Adiponectin, a circulating adipocyte-derived secretory protein, reportedly plays an important role in liver fibrosis development, although the biological role of adiponectin in liver fibrogenesis is still controversial. Adiponectin is present in the serum as three oligometric complexes; namely, high-, middle-, and low-molecular weight (HMW, MMW, and LMW, respectively). Adiponectin exerts different biological activities in an oligomerization-dependent manner. The aim of our current study was to examine the alteration of each isoform of adiponectin and its receptors (AdipoR1, AdipoR2, and T-cadherin) during the choline-deficient L-amino acid-defined (CDAA) diet-induced rat liver fibrosis development. We also elucidated the methylation status of all receptors. The serum level of total adiponectin significantly increased during the liver fibrosis development. Among the three isoforms, only HMW adiponectin was significantly up-regulated whereas MMW and LMW were not. The expression of T-cadherin, which exclusively binds with HMW adiponectin, was significantly augmented as well. The AdipoR2 expression was markedly decreased and showed no marked difference from that of AdipoR1. No obvious methylation change was observed in all three receptors, suggesting that another mechanism is involved in the alteration of receptor gene expression. Collectively, since the specific ligand and receptor were augmented together, crosstalk between HMW adiponectin and T-cadherin may play an important role during liver fibrosis development in rats. 相似文献
4.
Hitoshi Yoshiji Ryuichi Noguchi Mitsuteru Kitade Kosuke Kaji Yasuhide Ikenaka Tadashi Namisaki Junichi Yoshii Koji Yanase Masaharu Yamazaki Tatsuhiro Tsujimoto Takemi Akahane Hideto Kawaratani Masahito Uemura Hiroshi Fukui 《Journal of gastroenterology》2009,44(5):483-491
Background Branched-chain amino acids (BCAAs) reportedly inhibit the incidence of hepatocellular carcinoma (HCC) in patients with liver
cirrhosis and obesity that is frequently associated with insulin resistance (IR). However, the possible mechanism is still
obscure. The aim of the present study was to examine the effect of BCAAs, especially in conjunction with angiogenesis, on
hepatocarcinogenesis under the condition of IR.
Methods The effect of BCAAs on the development of liver enzyme-altered preneoplastic lesions and angiogenesis was examined in obese
diabetic Otsuka Long-Evans Tokushima Fatty rats. We also performed an in vitro study to elucidate the possible mechanisms
involved.
Results Treatment with BCAAs markedly inhibited glutathione-S-transferase placental form (GST-P)-positive preneoplastic lesions along with suppression of neovascularization in the liver.
The hepatic expression of vascular endothelial growth factor (VEGF), a potent angiogenic factor, was also attenuated. BCAA
treatment significantly suppressed glucose- and insulin-induced in vitro angiogenesis in the presence of VEGF.
Conclusions In obese diabetic rats BCAAs exerted a chemopreventive effect against HCC, associated with the suppression of VEGF expression
and hepatic neovascularization. Since BCAA preparations are widely used in clinical practice for patients with chronic liver
diseases, this agent may represent a new strategy for chemoprevention against HCC in the future. 相似文献
5.
Mitsuteru Yoshida Takanori Miyoshi Syoji Sakiyama Kazuya Kondo Akira Tangoku 《Surgery today》2013,43(7):806-808
A 53-year-old female with pemphigus vulgaris received treatment with prednisolone for 3 years. On chest computed tomography performed at follow-up, an anterior–mediastinal tumor (4 cm × 3 cm) was detected and diagnosed as a thymoma. Although amyosthenia was absent, the patient’s anti-acetylcholine-receptor antibody level was high, and she was positive for anti-desmoglein 3 antibodies. She underwent extended thymectomy in the same year, following which both the anti-acetylcholine receptor antibody and the anti-desmoglein 3 antibody levels were normalized. The patient’s skin symptoms improved, and the steroid dose was gradually lowered and finally discontinued 4 years postoperatively. Extended thymectomy may be an effective therapy for treating patients with pemphigus. 相似文献
6.
Cardiovascular risk factors associated with pulse pressure in a screened cohort in Okinawa, Japan. 总被引:6,自引:0,他引:6
Taku Inoue Mitsuteru Matsuoka Kazufumi Nagahama Chiho Iseki Takashi Touma Kunitoshi Iseki Kozen Kinjo Shuichi Takishita 《Hypertension research》2003,26(2):153-158
We evaluated the association between pulse pressure (PP) and cardiovascular risk factors in a screened cohort. Individuals who were receiving medications for hypertension or heart disease, who had no ECG record, or who had a record of arrhythmia were excluded. In total, 8,508 subjects (5,299 men and 3,209 women; age range, 18 to 89 years) were studied. Subjects were divided into four PP classes: PP.1 (PP < or = 40 mmHg, n=2,127), PP.2 (40 < or = PP < or = 44 mmHg, n=2,127), PP.3 (44 < or = PP < or = 50 mmHg, n=2,127) and PP.4 (50 mmHg < or = PP, n=2,127). Multiple regression analysis was used for evaluating the association between PP and cardiovascular risk factor or lifestyle. In men, the regression coefficient was 0.27 for age, 2.50 for diabetes mellitus, 0.33 for uric acid, 0.20 for body mass index, 0.07 for heart rate, -0.83 for current smoking habit and 1.23 for habitual drinking. In women, the regression coefficient was 0.37 for age, 4.09 for diabetes mellitus, 0.42 for body mass index, 0.14 for heart rate, and 0.84 for habitual exercise. In both men and women, PP was significantly increased in association with an increase in the number of risk factors (diabetes mellitus, obesity, current drinking status, heart rate, and hyperuricemia). In conclusion, higher PP was associated with cardiovascular risk factors. These associations were similar in both men and women. 相似文献
7.
Yoshiji H Kuriyama S Noguchi R Yoshii J Ikenaka Y Yanase K Namisaki T Kitade M Yamazaki M Masaki T Fukui H 《Journal of hepatology》2005,42(5):687-693
BACKGROUND/AIMS: Chemoprevention should be a promising approach to improve the prognosis of the patients with hepatocellular carcinoma (HCC). Angiogenesis is now recognized as a crucial step not only in tumor growth, but also in early carcinogenesis. The aim of this study was to elucidate the combination effect of the clinically used vitamin K(2) (VK) and the angiotensin-converting enzyme inhibitor, perindopril (PE), on hepatocarcinogenesis, especially in conjunction with angiogenesis. METHODS: In a diethylnitrosamine-induced rat hepatocarcinogenesis model, the effects of VK and PE on the development of liver enzyme-altered preneoplastic lesions and angiogenesis were examined. RESULTS: Treatment with both VK and PE markedly inhibited the development of preneoplastic lesions in association with suppression of neovascularization in the liver. The combination treatment with VK and PE exerted a more potent inhibitory effect as compared with the single agent treatments. The in vitro study demonstrated that VK and PE inhibited the endothelial cell (EC) tubular formation. VK also suppressed the EC proliferation in a dose-dependent manner. CONCLUSIONS: The combination of VK and PE exerted a chemopreventive effect against rat liver carcinogenesis via suppression of angiogenesis. Since both agents are widely used in the clinical practice, this combination therapy may represent a potential new strategy for chemoprevention against HCC in the future. 相似文献
8.
MPO-ANCA-positive Wegener’s granulomatosis presenting with hypertrophic cranial pachymeningitis: case report and review of the literature 总被引:1,自引:1,他引:1
Akahoshi M Yoshimoto G Nakashima H Miyake K Inoue Y Tanaka Y Tsukamoto H Horiuchi T Otsuka T Harada M 《Modern rheumatology / the Japan Rheumatism Association》2004,14(2):179-183
We describe a case of hypertrophic cranial pachymeningitis (HCP) associated with Wegeners granulomatosis (WG) in a 60-year-old man presenting with chronic headache and multiple cranial nerve neuropathies. A test for antibodies to the neutrophil cytoplasmic protein myeloperoxidase (MPO-ANCA) was positive in this case. We review the literature on perinuclear (p)-ANCA-related HCP, including our case. This case indicates the link between MPO-ANCA-positive WG and HCP. 相似文献
9.
Halting the interaction between vascular endothelial growth factor and its receptors attenuates liver carcinogenesis in mice 总被引:19,自引:0,他引:19
Yoshiji H Kuriyama S Yoshii J Ikenaka Y Noguchi R Hicklin DJ Wu Y Yanase K Namisaki T Kitade M Yamazaki M Tsujinoue H Masaki T Fukui H 《Hepatology (Baltimore, Md.)》2004,39(6):1517-1524
It has been shown that angiogenesis plays an important role not only in tumor growth, but also in early carcinogenesis. The expression of a potent angiogenic factor, vascular endothelial growth factor (VEGF), increased during the early stage of carcinogenesis. In this study, the effects of the neutralizing monoclonal antibodies R1 mAb and R2 mAb of the VEGF receptors Flt-1 (VEGFR-1) and KDR/Flk-1 (VEGFR-2), respectively, on murine hepatocarcinogenesis induced by diethylnitrosamine (DEN) were examined. The effects of R1 mAb and R2 mAb on spontaneous lung metastasis from hepatocellular carcinoma (HCC) were also investigated. VEGF expression and neovascularization in the tumor increased stepwise during hepatocarcinogenesis. Treatment with both R1 mAb and R2 mAb markedly inhibited the development of HCC and adenoma in the liver. The inhibitory effect of R2 mAb was more potent than that of R1 mAb, and the combination treatment with both mAbs almost completely attenuated hepatocarcinogenesis. Both R1 mAb and R2 mAb treatment significantly suppressed the development of angiogenesis in HCC. The suppressive effects against angiogenesis R1 mAb and R2 mAb were similar in magnitude to their inhibitory effects against hepatocarcinogenesis. Furthermore, spontaneous lung metastasis from HCC was also significantly suppressed by R1 mAb and R2 mAb treatment. In conclusion, these results suggest that VEGF and receptor interaction plays an important role in hepatocarcinogenesis and in spontaneous lung metastasis from HCC. 相似文献
10.
Takashi Kitagataya Goki Suda Kazunori Nagashima Takehiko Katsurada Koji Yamamoto Megumi Kimura Osamu Maehara Ren Yamada Taku Shigesawa Kazuharu Suzuki Akihisa Nakamura Masatsugu Ohara Machiko Umemura Naoki Kawagishi Masato Nakai Takuya Sho Mitsuteru Natsuizaka Kenichi Morikawa Koji Ogawa Shunsuke Ohnishi Yoshito Komatsu Hiroo Hata Satoshi Takeuchi Takashige Abe Jun Sakakibara-Konishi Takanori Teshima Akihiro Homma Naoya Sakamoto 《Journal of gastroenterology and hepatology》2020,35(10):1782-1788