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Corentin M. Barbu Alison M. Buttenheim Maria-Luz Hancco Pumahuanca Javier E. Quintanilla Calderón Renzo Salazar Malwina Carrión Andy Catacora Rospigliossi Fernando S. Malaga Chavez Karina Oppe Alvarez Juan Cornejo del Carpio César Náquira Michael Z. Levy 《Emerging infectious diseases》2014,20(12):2055-2063
Chagas disease vector control campaigns are being conducted in Latin America, but little is known about medium-term or long-term effectiveness of these efforts, especially in urban areas. After analyzing entomologic data for 56,491 households during the treatment phase of a Triatoma infestans bug control campaign in Arequipa, Peru, during 2003–2011, we estimated that 97.1% of residual infestations are attributable to untreated households. Multivariate models for the surveillance phase of the campaign obtained during 2009–2012 confirm that nonparticipation in the initial treatment phase is a major risk factor (odds ratio [OR] 21.5, 95% CI 3.35–138). Infestation during surveillance also increased over time (OR 1.55, 95% CI 1.15–2.09 per year). In addition, we observed a negative interaction between nonparticipation and time (OR 0.73, 95% CI 0.53–0.99), suggesting that recolonization by vectors progressively dilutes risk associated with nonparticipation. Although the treatment phase was effective, recolonization in untreated households threatens the long-term success of vector control. 相似文献
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Multifocal VEP and mfERG techniques show promise for routine clinical use in neuro-ophthalmology. OCT is now used in many subspecialty areas of ophthalmology, especially in studies of the retina and glaucoma. Although neuro-ophthalmologists must still rely on time-consuming history taking and careful clinical examination, the three modalities described herein can provide objective proof regarding clinical diagnoses in selected cases, saving time and avoiding costly neurologic investigations. 相似文献
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Incidence and clinicobiologic characteristics of leukemic B-cell chronic lymphoproliferative disorders with more than one B-cell clone 总被引:1,自引:0,他引:1
Sanchez ML Almeida J Gonzalez D Gonzalez M Garcia-Marcos MA Balanzategui A Lopez-Berges MC Nomdedeu J Vallespi T Barbon M Martin A de la Fuente P Martin-Nuñez G Fernandez-Calvo J Hernandez JM San Miguel JF Orfao A 《Blood》2003,102(8):2994-3002
Leukemic B-chronic lymphoproliferative disorders (B-CLPDs) are generally believed to derive from a monoclonal B cell; biclonality has only occasionally been reported. In this study, we have explored the incidence of B-CLPD cases with 2 or more B-cell clones and established both the phenotypic differences between the coexisting clones and the clinicobiologic features of these patients. In total, 53 B-CLPD cases with 2 or more B-cell clones were studied. Presence of 2 or more B-cell clones was suspected by immunophenotype and confirmed by molecular/genetic techniques in leukemic samples (n = 42) and purified B-cell subpopulations (n = 10). Overall, 4.8% of 477 consecutive B-CLPDs had 2 or more B-cell clones, their incidence being especially higher among hairy cell leukemia (3 of 13), large cell lymphoma (2 of 10), and atypical chronic lymphocytic leukemia (CLL) (4 of 29). In most cases the 2 B-cell subsets displayed either different surface immunoglobulin (sIg) light chain (n = 37 of 53) or different levels of the same sIg (n = 9 of 53), usually associated with other phenotypic differences. Compared with monoclonal cases, B-CLL patients with 2 or more clones had lower white blood cell (WBC) and lymphocyte counts, more frequently displayed splenomegaly, and required early treatment. Among these, the cases in which a CLL clone coexisted with a non-CLL clone were older and more often displayed B symptoms, a monoclonal component, and diffuse infiltration of bone marrow and required early treatment more frequently than cases with monoclonal CLL or 2 CLL clones. 相似文献
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Tumoral and choroidal vascularization: differential cellular mechanisms involving plasminogen activator inhibitor type I
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Jost M Maillard C Lecomte J Lambert V Tjwa M Blaise P Alvarez Gonzalez ML Bajou K Blacher S Motte P Humblet C Defresne MP Thiry M Frankenne F Gothot A Carmeliet P Rakic JM Foidart JM Noël A 《The American journal of pathology》2007,171(4):1369-1380
An adequate balance between serine proteases and their plasminogen activator inhibitor-1 (PAI-1) is critical for pathological angiogenesis. PAI-1 deficiency in mice is associated with impaired choroidal neovascularization (CNV) and tumoral angiogenesis. In the present work, we demonstrate unexpected differences in the contribution of bone marrow (BM)-derived cells in these two processes regulated by PAI-1. PAI-1(-/-) mice grafted with BM-derived from wild-type mice were able to support laser-induced CNV formation but not skin carcinoma vascularization. Engraftment of irradiated wild-type mice with PAI-1(-/-) BM prevented CNV formation, demonstrating the crucial role of PAI-1 delivered by BM-derived cells. In contrast, the transient infiltration of tumor transplants by local PAI-1-producing host cells rather than by BM cells was sufficient to rescue tumor growth and angiogenesis in PAI-1-deficient mice. These data identify PAI-1 as a molecular determinant of a local permissive soil for tumor angiogenesis. Altogether, the present study demonstrates that different cellular mechanisms contribute to PAI-1-regulated tumoral and CNV. PAI-1 contributes to BM-dependent choroidal vascularization and to BM-independent tumor growth and angiogenesis. 相似文献
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Faisy C Pinto FM Le Guen M Naline E Grassin Delyle S Sage E Candenas ML Devillier P 《Critical care (London, England)》2011,15(5):R208
Introduction
Lung inflation may have deleterious effects on the alveoli during mechanical ventilation. However, the consequences of stretch during excessive lung inflation on basal tone and responsiveness of human bronchi are unknown. This study was undertaken to devise an experimental model of acute mechanical stretch in isolated human bronchi and to investigate its effect on airway tone and responsiveness. 相似文献9.
McAleer D McPhillips FM FitzGerald SP McConnell RI Rodriguez ML 《Journal of immunoassay & immunochemistry》2006,27(4):363-378
The semiautomated Evidence Investigator has been applied to the simultaneous specific measurement of soluble adhesion molecules: L-, P-, E- selectins, VCAM-1, ICAM-1 using a reduced volume of sample. The biochip is the solid support and vessel where the sandwich immunoassay takes place. Signal detection, imaging, data processing, and storage are fully automated. Calibration curves are generated simultaneously for each analyte, with automatic validation against supplied calibration data. These curves are used for the calculation of the concentrations in multi-analyte controls and human serum samples. Data from the evaluation parameters assessed indicate suitability of the Evidence Investigator system for the application. 相似文献