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Keli M. Turner Kunmi Majekodunmi Alif Manejwala David Neschis Zina Novak Cherif Boutros 《Journal of gastrointestinal surgery》2014,18(3):638-640
Celiac axis stenosis caused by extrinsic compression by the median arcuate ligament (MAL) is present in up to 5 % of patients undergoing pancreaticoduodenectomy. Failure to identify and manage MAL compression can lead to potentially devastating postoperative consequences that include frank liver necrosis and death. We report an incidental discovery of celiac axis stenosis by MAL in a patient prepared for pancreaticoduodenectomy. Image findings and operative management are discussed. 相似文献
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Langzhou Song Yi Zhang Nadezhda E. Yun Allison L. Poussard Jeanon N. Smith Jennifer K. Smith Viktoriya Borisevich Jenna J. Linde Michele A. Zacks Hong Li Uma Kavita Lucia Reiserova Xiangyu Liu Kunmi Dumuren Bhuvaneswari Balasubramanian Bruce Weaver Jason Parent Scott Umlauf Ge Liu Jim Huleatt Lynda Tussey Slobodan Paessler 《Vaccine》2009
Transmission of highly pathogenic avian influenza (HPAI) between birds and humans is an ongoing threat that holds potential for the emergence of a pandemic influenza strain. A major barrier to an effective vaccine against avian influenza has been the generally poor immunopotency of many of the HPAI strains coupled with the manufacturing constraints employing conventional methodologies. Fusion of flagellin, a toll-like receptor-5 ligand, to vaccine antigens has been shown to enhance the immune response to the fused antigen in preclinical studies. Here, we have evaluated the immunogenicity and efficacy of a panel of flagellin-based hemagglutinin (HA) globular head fusion vaccines in inbred mice. The HA globular head of these vaccines is derived from the A/Vietnam/1203/04 (VN04; H5N1) HA molecule. We find that replacement of domain D3 of flagellin with the VN04 HA globular head creates a highly effective vaccine that elicits protective HAI titers which protect mice against disease and death in a lethal challenge model. 相似文献
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