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Shilo Smadar Bar Noam Keshet Ayya Talmor-Barkan Yeela Rossman Hagai Godneva Anastasia Aviv Yaron Edlitz Yochai Reicher Lee Kolobkov Dmitry Wolf Bat Chen Lotan-Pompan Maya Levi Kohava Cohen Ori Saranga Hila Weinberger Adina Segal Eran 《European journal of epidemiology》2021,36(11):1187-1194
European Journal of Epidemiology - The 10 K is a large-scale prospective longitudinal cohort and biobank that was established in Israel. The primary aims of the study include development... 相似文献
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Amir Bieber Doron Markovits Kohava Toledano Yonit Tavor Reuven Mader Alexandra Balbir-Gurman Yolanda Braun-Moscovici 《Medicine》2022,101(24)
Hypocomplementemia has been reported in patients with rheumatoid arthritis treated with tocilizumab (TCZ), but its long-term consequences are unknown. We assessed the long-term outcome of patients treated with TCZ who developed hypocomplementemia regarding serious bacterial infections or autoimmune diseases (AID).The charts of patients treated with TCZ at two rheumatology centers were reviewed retrospectively. Data regarding patients’ age, gender, disease duration, autoantibodies status, previous or concomitant treatments, blood counts, liver enzymes, C3 and C4 levels at baseline and during TCZ treatment, episodes of infections, allergic reactions, and AID were analyzed. Univariate analysis was used to compare patients with low C3, C4 levels versus patients with normal C3, C4 levels. Variables that were statistically significant associated or tended to be associated with low C3 or C4 were included in multiple variable logistic regression.Of 132 patients treated with TCZ, 108 had serial measurements of serum complement concentration. Thirty-three (30%) patients developed low C4 levels and 23 (21%) had also low C3. Mean TCZ treatment period was 4.9 years (range, 1–14 years). All patients had normal complement levels at baseline. Leukopenia occurred in 18 (16.7%) patients, 14 of whom (77%) had low complement. Persistent leukopenia was observed in 8% and 5.3% of patients with normal C3 and C4 levels, respectively, as opposed to 47% and 42% of patients with low C3 or low C4, respectively. Low C3, C4 levels correlated with prolonged TCZ treatment retention time and effectiveness. There were no serious bacterial infections or new onset AID.Hypocomplementemia during TCZ treatment was accompanied by leukopenia that correlated with treatment duration. Hypocomplementemia was not associated with serious bacterial infections or new onset AID. Decreased complement levels were associated with treatment longevity. The role of monitoring complement level in predicting treatment response or assessing disease activity deserves further investigation. 相似文献
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Michal Amit Judith Chebath Victoria Margulets Ilana Laevsky Yael Miropolsky Kohava Shariki Meital Peri Idit Blais Guy Slutsky Michel Revel Joseph Itskovitz-Eldor 《Stem cell reviews》2010,6(2):248-259
Alongside their contribution to research, human embryonic stem cells (hESC) may also prove valuable for cell-based therapies. Traditionally, these cells have been grown in adhesion culture either with or without feeder cells, allowing for their continuous growth as undifferentiated cells. However, to be applicable in therapy and industry they must be produced in a scalable and controlled process. Here we present for the first time a suspension culture system for undifferentiated hESC and induced pluripotent stem cells (iPSC), based on medium supplemented with the IL6RIL6 chimera (interleukin-6 receptor fused to interleukin-6), and basic fibroblast growth factor. Four hESC lines cultured in this system maintained all ESC features after 20 passages, including stable karyotype and pluripotency. Similar results were obtained when hESC were replaced with iPSC from two different cell lines. We demonstrate that the IL6RIL6 chimera supports the self-renewal and expansion of undifferentiated hESC and iPSC in suspension, and thus present another efficient system for large-scale propagation of undifferentiated pluripotent cells for clinical and translational applications. 相似文献
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Bishara Rema Braun-Moscovici Yolanda Dagan Amir Toledano Kohava Saadi Tarek Sabo Edmond Balbir-Gurman Alexandra 《Clinical rheumatology》2016,35(3):795-800
Clinical Rheumatology - A 19-year old previously healthy man developed the adult-onset Still’s disease (AOSD) with high ferritin levels. Corticosteroids induced clinical remission with... 相似文献
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