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1.
Maria Nadinskaia Marina Maevskaya Vladimir Ivashkin Khava Kodzoeva Irina Pirogova Evgeny Chesnokov Alexander Nersesov Jamilya Kaibullayeva Akzhan Konysbekova Aigul Raissova Feruza Khamrabaeva Elena Zueva 《World journal of gastroenterology : WJG》2021,27(10):959-975
BACKGROUNDAtherosclerotic cardiovascular disease (ASCVD) is the leading cause of mortality in patients with nonalcoholic fatty liver disease (NAFLD). Weight loss is a key factor for successful NAFLD and CVD therapy. Ursodeoxycholic acid (UDCA), which is one of the first-line therapeutic agents for treatment of NAFLD, is reported to have a beneficial effect on dyslipidemia and ASCVD risk because of antioxidant properties.AIMTo evaluate the effects of 6 mo of UDCA treatment on hepatic function tests, lipid profile, hepatic steatosis and fibrosis, atherogenesis, and ASCVD risk in men and women with NAFLD, as well as to assess the impact of > 5% weight reduction on these parameters.METHODSAn open-label, multicenter, international noncomparative trial was carried out at primary health care settings and included 174 patients with ultrasound-diagnosed NAFLD who received 15 mg/kg/d UDCA for 6 mo and were prescribed lifestyle modification with diet and exercise. The efficacy criteria were liver enzymes, lipid profile, fatty liver index (FLI), noninvasive liver fibrosis tests (nonalcoholic fatty liver disease fibrosis score and liver fibrosis index), carotid intima-media thickness (CIMT), and ASCVD risk score. To test statistical hypotheses, the Wilcoxon test, paired t-test, Fisher’s exact test, and Pearson''s chi-squared test were used. RESULTSThe alanine aminotransferase (ALT) level changed by -14.1 U/L (-31.0; -5.3) from baseline to 3 mo and by -6.5 U/L (-14.0; 0.1) from 3 to 6 mo. The magnitude of ALT, aspartate transaminase, and glutamyltransferase decrease was greater during the first 3 mo of treatment compared to the subsequent 3 mo (P < 0.001, P < 0.01, P < 0.001, respectively). At 6 mo, in the total sample, we observed a statistically significant decrease in body weight and levels of FLI: 84.9 ± 10.4 vs 72.3 ± 17.6, P < 0.001, total cholesterol: 6.03 ± 1.36 vs 5.76 ± 1.21, Р < 0.001, low-density lipoprotein: 3.86 ± 1.01 vs 3.66 ± 0.91, Р < 0.001, and triglyceride: 3.18 (2.00; 4.29) vs 2.04 (1.40; 3.16), Р < 0.001. No effect on nonalcoholic fatty liver disease fibrosis score or liver fibrosis index was found. The CIMT decreased significantly in the total sample (0.985 ± 0.243 vs 0.968 ± 0.237, P = 0.013), whereas the high-density lipoprotein (Р = 0.036) and 10-year ASCVD risk (Р = 0.003) improved significantly only in women. Fifty-four patients (31%) achieved > 5% weight loss. At the end of the study, the FLI decreased significantly in patients with (88.3 ± 10.2 vs 71.4 ± 19.6, P < 0.001) and without > 5% weight loss (83.5 ± 10.3 vs 72.8 ± 16.7, P < 0.001). The changes in ALT, aspartate transaminase, glutamyltransferase, total cholesterol, and low-density lipoprotein levels were similar between the subgroups.CONCLUSIONUDCA normalizes liver enzymes greatly within the first 3 mo of treatment, improves lipid profile and hepatic steatosis independent of weight loss, and has a positive effect on CIMT in the total sample and 10-year ASCVD risk in women after 6 mo of treatment. 相似文献
2.
I. Ya. Tsukerman K. V. Yaremenko S. G. Ibragimova 《Bulletin of experimental biology and medicine》1988,106(4):1472-1473
Research Institute of Oncology and Research Institute of Pharmacology, Tomsk Scientific Center, Academy of Medical Sciences of the USSR. (Presented by Academician of the Academy of Medical Sciences of the USSR N. V. Vasil'ev.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 106, No. 10, pp. 472–473, October, 1988. 相似文献
3.
G S Zefirova G V Ibragimova L V Kondrat'eva L V Shchepetkova N L Davitinidze 《Terapevticheski? arkhiv》1984,56(10):66-70
The most informative diagnostic criteria of autoimmune thyroiditis were revealed. A kit of diagnostic tests were offered for each version of autoimmune thyroiditis. The lowest percentage of antibodies against thyroglobulin was demonstrated for the hyperthyroid hypertrophic version of autoimmune thyroiditis, while the highest for its atrophic pattern. Biopsy of the thyroid was found to be the most informative test for autoimmune thyroiditis, provided the result was positive. If the result of puncture biopsy is negative, it is desirable to apply a complex of tests depending on thyroid function and size. 相似文献
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G S Zefirova G V Ibragimova M Sh Be?sugurov B I Shmushkovich 《Terapevticheski? arkhiv》1986,58(10):114-117
The authors discuss the advantages of the use of glucocorticoids in the treatment of autoimmune diseases, if the drugs are administered every other day. A total of 149 patients with autoimmune thyroiditis, endocrine ophthalmopathy, myasthenia and bronchial asthma were examined. Of these, 3 patients received glucocorticoids every other day, whereas the remainder took them every day. The former method consisted in the use of a single daily dose of glucocorticoids (20 to 80 mg) at 7 to 8 o'clock in the morning over 2 months to 5 years. The function of the pituitary-adrenal system was tested by the measurement of the blood content of ACTH, hydrocortisone and testosterone with the aid of a kit of standard tests. It was shown that glucocorticoids administered every other day did not produce any suppression of the pituitary-adrenal system in contrast to those who received prednisolone every day. The lack of the side effects in the form of exogenous hypercorticoidism can be explained by the anabolic action of steroid hormones produced by the reticular zone of the adrenal cortex. Examination of the blood serum content of testosterone in women who received glucocorticoids every other day has demonstrated that modulations in its secretion were similar to those in the content of ACTH and hydrocortisone. Thus, the stimulating hormonal therapy with glucocorticoids administered every other day appears more physiological as compared to the daily schedule. 相似文献
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9.
E. P. Kasatkina D. E. Shilin A. L. Rosenbloom M. I. Pykov G. V. Ibragimova V. N. Sokolovskaya A. N. Matkovskaya T. N. Volkova E. A. Odoud M. I. Bronshtein A. M. Poverenny N. M. Mursankova 《European journal of pediatrics》1997,156(12):916-920
To determine the effects of low dose radiation from 131I and 137Cs resulting from the Chernobyl disaster on the expression of endemic goiter in children, we studied children in regions with
and without evidence of radiocontamination but comparable iodine insufficiency. We included 89 children in the study (radiocontaminated)
region (SR) and 116 in the control region (CR) because they were either fetuses, infants, or pre-adolescents at the time of
exposure. We evaluated thyroid dimensions by clinical examination and ultrasound; thyroid function by hormonal levels, and
thyroglobulin measurement; histology of the thyroid by fine needle aspiration; and thyroid autoimmunity. SR subjects had 5
times the frequency of thyroid enlargement as those from CR, greatest in the younger patients. There were no instances of
clinically apparent thyroid dysfunction. Antithyroid microsomal and antithyroglobulin antibodies were present in a markedly
greater percentage of SR subjects. Fine needle biopsy demonstrated greater cellular proliferation in samples from SR.
Conclusions We have demonstrated findings of autoimmune thyroid disease at markedly increased frequency in a population of children with
poor iodine nutriture who were exposed to low level radiation, compared to a more iodine deficient population not so exposed.
These results suggest that low level radiation may induce thyroid gland changes in children who have inadequate iodine intake
nutriture and reinforce the importance of adequate dietary iodine.
Received: 14 June 1996 / Accepted in revised form: 20 June 1997 相似文献
10.
van Doorslaer E O'Donnell O Rannan-Eliya RP Somanathan A Adhikari SR Garg CC Harbianto D Herrin AN Huq MN Ibragimova S Karan A Lee TJ Leung GM Lu JF Ng CW Pande BR Racelis R Tao S Tin K Tisayaticom K Trisnantoro L Vasavid C Zhao Y 《Health economics》2007,16(11):1159-1184
Out-of-pocket (OOP) payments are the principal means of financing health care throughout much of Asia. We estimate the magnitude and distribution of OOP payments for health care in fourteen countries and territories accounting for 81% of the Asian population. We focus on payments that are catastrophic, in the sense of severely disrupting household living standards, and approximate such payments by those absorbing a large fraction of household resources. Bangladesh, China, India, Nepal and Vietnam rely most heavily on OOP financing and have the highest incidence of catastrophic payments. Sri Lanka, Thailand and Malaysia stand out as low to middle income countries that have constrained both the OOP share of health financing and the catastrophic impact of direct payments. In most low/middle-income countries, the better-off are more likely to spend a large fraction of total household resources on health care. This may reflect the inability of the poorest of the poor to divert resources from other basic needs and possibly the protection of the poor from user charges offered in some countries. But in China, Kyrgyz and Vietnam, where there are no exemptions of the poor from charges, they are as, or even more, likely to incur catastrophic payments. 相似文献