全文获取类型
收费全文 | 258篇 |
免费 | 5篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 33篇 |
妇产科学 | 8篇 |
基础医学 | 32篇 |
口腔科学 | 6篇 |
临床医学 | 11篇 |
内科学 | 29篇 |
皮肤病学 | 4篇 |
神经病学 | 36篇 |
特种医学 | 26篇 |
外科学 | 15篇 |
综合类 | 1篇 |
预防医学 | 16篇 |
眼科学 | 2篇 |
药学 | 22篇 |
中国医学 | 4篇 |
肿瘤学 | 15篇 |
出版年
2022年 | 4篇 |
2021年 | 17篇 |
2020年 | 3篇 |
2018年 | 6篇 |
2017年 | 5篇 |
2016年 | 10篇 |
2015年 | 15篇 |
2014年 | 17篇 |
2013年 | 14篇 |
2012年 | 16篇 |
2011年 | 35篇 |
2010年 | 19篇 |
2009年 | 18篇 |
2008年 | 18篇 |
2007年 | 16篇 |
2006年 | 9篇 |
2005年 | 9篇 |
2004年 | 8篇 |
2003年 | 3篇 |
2002年 | 6篇 |
2001年 | 3篇 |
2000年 | 1篇 |
1999年 | 1篇 |
1998年 | 1篇 |
1996年 | 2篇 |
1994年 | 1篇 |
1991年 | 2篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1987年 | 1篇 |
排序方式: 共有264条查询结果,搜索用时 15 毫秒
1.
MIA SON JEONG‐OK KONG SANG‐BAEK KOH JAEYOUNG KIM MIKKO HÄRMÄ 《Journal of sleep research》2008,17(4):385-394
We investigated the effects of 12‐hour shift work for five to seven consecutive days and overtime on the prevalence of severe sleepiness in the automobile industry in Korea. [Correction added after online publication 28 Nov: Opening sentence of the summary has been rephrased for better clarity.] A total of 288 randomly selected male workers from two automobile factories were selected and investigated using questionnaires and sleep‐wake diaries in South Korea. The prevalence of severe sleepiness at work [i.e. Karolinska Sleepiness Scale (KSS) score of 7 or higher] was modeled using marginal logistic regression and included theoretical risk factors related to working hours and potential confounding factors related to socio‐economic status, work demands, and health behaviors. Factors related to working hours increased the risk for severe sleepiness at the end of the shift in the following order: the night shift [odds ratio (OR): 4.7; 95% confidence interval (CI): 3.6–6.0)], daily overtime (OR: 2.2; 95% CI: 1.7–2.9), weekly overtime (OR: 1.6; 95% CI: 1.0–2.6), and night overtime (OR: 1.6; 95% CI: 0.8–3.0). Long working hours and shift work had a significant interactive effect for severe sleepiness at work. Night shift workers who worked for 12 h or more a day were exposed to a risk of severe sleepiness that was 7.5 times greater than day shift workers who worked less than 11 h. Night shifts and long working hours were the main risk factors for severe sleepiness among automobile factory workers in Korea. Night shifts and long working hours have a high degree of interactive effects resulting in severe sleepiness at work, which highlight the need for immediate measures to address these characteristics among South Korean labor force patterns. 相似文献
2.
Jae-Hun Jung Eun-Ah Kim Sang-Yoon Lee Jung-Eun Moon Eun-Joo Lee Sook-Hyun Park 《Nutrients》2021,13(6)
We aimed to investigate the changes in vitamin D levels and factors associated with vitamin D deficiency (VDD) during the first year of life in Korean preterm infants. We enrolled 333 preterm infants who were born at Kyungpook National University Children’s Hospital between March 2013 and December 2019. 25-hydroxyvitamin D (25-OHD) levels and medical records were collected at birth, 6 months, and 12 months of age. The mean gestational age was 33.4 ± 2.3 weeks and mean 25-OHD levels at birth were 18.2 ± 13.5 ng/mL. The incidence of VDD was 82.8%, 30.6%, and 27.0% at birth, 6 months, and 12 months, respectively. The incidence of severe VDD (25-OHD < 10 ng/mL) was 31.5%, 1.5%, and 0%, at birth, 6 months, and 12 months, respectively. Among infants with severe VDD, the deficiency persisted in 49.6% at 6 months, and 35.3% at 12 months. The strongest predictor of VDD during follow-up was 25-OHD concentration at birth. Vitamin D supplementation at 400 IU/day did not affect vitamin D levels during the first year of life. Therefore, it is important to prevent neonatal VDD through maternal vitamin D supplementation during pregnancy. Further research is needed to determine the optimal vitamin D supplementation dose for Korean preterm infants. 相似文献
3.
4.
Katja Apelt Susan M. White Hyun Suk Kim Jung-Eun Yeo Angela Kragten Annelotte P. Wondergem Martin A. Rooimans Romn Gonzlez-Prieto Wouter W. Wiegant Sebastian Lunke Daniel Flanagan Sarah Pantaleo Catherine Quinlan Winita Hardikar Haico van Attikum Alfred C.O. Vertegaal Brian T. Wilson Rob M.F. Wolthuis Orlando D. Schrer Martijn S. Luijsterburg 《The Journal of experimental medicine》2021,218(3)
ERCC1-XPF is a multifunctional endonuclease involved in nucleotide excision repair (NER), interstrand cross-link (ICL) repair, and DNA double-strand break (DSB) repair. Only two patients with bi-allelic ERCC1 mutations have been reported, both of whom had features of Cockayne syndrome and died in infancy. Here, we describe two siblings with bi-allelic ERCC1 mutations in their teenage years. Genomic sequencing identified a deletion and a missense variant (R156W) within ERCC1 that disrupts a salt bridge below the XPA-binding pocket. Patient-derived fibroblasts and knock-in epithelial cells carrying the R156W substitution show dramatically reduced protein levels of ERCC1 and XPF. Moreover, mutant ERCC1 weakly interacts with NER and ICL repair proteins, resulting in diminished recruitment to DNA damage. Consequently, patient cells show strongly reduced NER activity and increased chromosome breakage induced by DNA cross-linkers, while DSB repair was relatively normal. We report a new case of ERCC1 deficiency that severely affects NER and considerably impacts ICL repair, which together result in a unique phenotype combining short stature, photosensitivity, and progressive liver and kidney dysfunction. 相似文献
5.
6.
Sol Jeong Dong-Hun Lee Jung-Hoon Kwon Yu-Jin Kim Sun-Hak Lee Andrew Y. Cho Tae-Hyeon Kim Jung-Eun Park Song-I Lee Chang-Seon Song 《Viruses》2020,12(12)
In October 2020, a highly pathogenic avian influenza (HPAI) subtype H5N8 virus was identified from a fecal sample of a wild mandarin duck (Aix galericulata) in South Korea. We sequenced all eight genome segments of the virus, designated as A/Mandarin duck/Korea/K20-551-4/2020(H5N8), and conducted genetic characterization and comparative phylogenetic analysis to track its origin. Genome sequencing and phylogenetic analysis show that the hemagglutinin gene belongs to H5 clade 2.3.4.4 subgroup B. All genes share high levels of nucleotide identity with H5N8 HPAI viruses identified from Europe during early 2020. Enhanced active surveillance in wild and domestic birds is needed to monitor the introduction and spread of HPAI via wild birds and to inform the design of improved prevention and control strategies. 相似文献
7.
Joiner WM Lee JE Shelhamer M 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2007,181(2):307-320
The ability to make predictive saccadic eye movements is dependent on neural signals that anticipate the onset of a visual
target. We used a novel paradigm—based on the saccade-countermanding task—as a tool to investigate rhythm saccade pacing and
to provide information on the mechanisms of predictive timing. In particular, we examined the ability of normal subjects to
stop a sequence of periodically paced eye movements when cued by a stop signal that was presented at different times with
respect to the last target of the sequence (stop signal delay, SSD). The timing of the stop signal affected the ability to
stop the saccadic sequence (make a saccade to a central target rather than to the peripheral alternating targets) in different
ways, depending on the preceding tracking behavior. For the same SSD, subjects cancelled fewer trials during predictive tracking
(promoted by tracking targets alternating at a fast pacing rate, 1.0 Hz) than during reactive tracking (tracking alternating
targets at a low pacing rate, 0.2 Hz). In addition, on non-canceled trials, there was an increase in the delay of the corrective
saccade to the central target with increasing SSD for pacing at 0.2 Hz, but the timing of the corrective saccade remained
near constant for 1.0 Hz pacing. In examining the timing between movements, we estimate that the repetitive GO process that
drives the saccades during predictive tracking begins earlier and has a shorter duration than the repetitive GO process during reactive tracking. These behavioral results provide further insight into the initiation process of predictive responses. In particular,
the reduced reaction time and the corresponding short duration of the predictive process may result from a faster accumulation
of neuronal discharge to a relatively fixed threshold. 相似文献
8.
Lee JY Choo JE Choi YS Park JB Min DS Lee SJ Rhyu HK Jo IH Chung CP Park YJ 《Biomaterials》2007,28(29):4257-4267
Bioactive scaffolds inducing cell adhesion, differentiation have been premise for optimal formation of target tissue. Collagen has been employed as a tissue regenerative scaffold especially for bone regeneration and has been chemically surface-modified to present bioactivity. Herein, we show that peptide, denoted as collagen-binding motif (CBM, GLRSKSKKFRRPDIQYPDATDEDITSHM) identified from osteopontin (OPN) protein, was able to specifically bind collagen without chemical conjugation, while presenting apatite forming capability in vitro and in vivo. Collagen surface alone was not able to induce noticeable apatite nucleation however, mineralization was evident when assembled with CBM peptide, implying that the collagen-CBM assembly played a pivotal role in biomineralization. In vivo result further demonstrated that the CBM peptide in complex with material was able to induce bone formation by helping mineralization in the bone defect. Taken together, the CBM peptide herein and its assembly with collagen can be applied as an inducer of biomineralization as well as a bioactive scaffold for bone regeneration. 相似文献
9.
Sook Hyon Ahn Ji Yeoun Lee Kyu-Chang Wang Sung-Hye Park Jung-Eun Cheon Ji Hoon Phi Seung-Ki Kim 《Child's nervous system》2014,30(2):345-350
Introduction
Alveolar soft part sarcoma (ASPS), a rare soft tissue malignant neoplasm, frequently metastasizes to the brain. However, primary intracranial ASPS is extremely rare. We present a case of primary intracranial ASPS arising from the cerebellopontine angle (CPA) without demonstrable systemic lesions.Case report
An 11-year-old girl presented with a recurrent tumor in the right CPA after a partial resection and radiation therapy (RT). Near-total resection with a minimal tumor left in the jugular foramen was performed. The pathological diagnosis was ASPS. There was no evidence of primary extracranial tumors. She underwent adjuvant chemotherapy and gamma knife surgery. At 29 months after the second surgery, magnetic resonance imaging revealed multifocal enhancing lesions at the prepontine cistern, right CPA and medulla oblongata, despite intensive treatment. However, extracranial metastasis was not noted. This case suggested a poor outcome of primary intracranial ASPS, similar to extracranial ASPS. 相似文献10.
Jae Won Choi Yeon Jin Cho Ji Young Ha Yun Young Lee Seok Young Koh June Young Seo Young Hun Choi Jung-Eun Cheon Ji Hoon Phi Injoon Kim Jaekwang Yang Woo Sun Kim 《Korean journal of radiology》2022,23(3):343
ObjectiveTo develop and evaluate a deep learning-based artificial intelligence (AI) model for detecting skull fractures on plain radiographs in children.Materials and MethodsThis retrospective multi-center study consisted of a development dataset acquired from two hospitals (n = 149 and 264) and an external test set (n = 95) from a third hospital. Datasets included children with head trauma who underwent both skull radiography and cranial computed tomography (CT). The development dataset was split into training, tuning, and internal test sets in a ratio of 7:1:2. The reference standard for skull fracture was cranial CT. Two radiology residents, a pediatric radiologist, and two emergency physicians participated in a two-session observer study on an external test set with and without AI assistance. We obtained the area under the receiver operating characteristic curve (AUROC), sensitivity, and specificity along with their 95% confidence intervals (CIs).ResultsThe AI model showed an AUROC of 0.922 (95% CI, 0.842–0.969) in the internal test set and 0.870 (95% CI, 0.785–0.930) in the external test set. The model had a sensitivity of 81.1% (95% CI, 64.8%–92.0%) and specificity of 91.3% (95% CI, 79.2%–97.6%) for the internal test set and 78.9% (95% CI, 54.4%–93.9%) and 88.2% (95% CI, 78.7%–94.4%), respectively, for the external test set. With the model’s assistance, significant AUROC improvement was observed in radiology residents (pooled results) and emergency physicians (pooled results) with the difference from reading without AI assistance of 0.094 (95% CI, 0.020–0.168; p = 0.012) and 0.069 (95% CI, 0.002–0.136; p = 0.043), respectively, but not in the pediatric radiologist with the difference of 0.008 (95% CI, -0.074–0.090; p = 0.850).ConclusionA deep learning-based AI model improved the performance of inexperienced radiologists and emergency physicians in diagnosing pediatric skull fractures on plain radiographs. 相似文献