全文获取类型
收费全文 | 826篇 |
免费 | 55篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 3篇 |
妇产科学 | 6篇 |
基础医学 | 135篇 |
口腔科学 | 9篇 |
临床医学 | 108篇 |
内科学 | 203篇 |
皮肤病学 | 14篇 |
神经病学 | 46篇 |
特种医学 | 43篇 |
外科学 | 66篇 |
综合类 | 6篇 |
一般理论 | 9篇 |
预防医学 | 76篇 |
眼科学 | 4篇 |
药学 | 91篇 |
肿瘤学 | 45篇 |
出版年
2022年 | 3篇 |
2021年 | 11篇 |
2020年 | 5篇 |
2019年 | 10篇 |
2018年 | 14篇 |
2017年 | 14篇 |
2016年 | 11篇 |
2015年 | 29篇 |
2014年 | 31篇 |
2013年 | 42篇 |
2012年 | 40篇 |
2011年 | 54篇 |
2010年 | 27篇 |
2009年 | 35篇 |
2008年 | 54篇 |
2007年 | 50篇 |
2006年 | 51篇 |
2005年 | 47篇 |
2004年 | 50篇 |
2003年 | 47篇 |
2002年 | 30篇 |
2001年 | 28篇 |
2000年 | 15篇 |
1999年 | 17篇 |
1998年 | 9篇 |
1997年 | 4篇 |
1996年 | 10篇 |
1995年 | 3篇 |
1992年 | 3篇 |
1991年 | 4篇 |
1990年 | 6篇 |
1989年 | 7篇 |
1988年 | 12篇 |
1987年 | 7篇 |
1986年 | 6篇 |
1985年 | 4篇 |
1984年 | 7篇 |
1983年 | 10篇 |
1980年 | 4篇 |
1978年 | 4篇 |
1974年 | 5篇 |
1968年 | 4篇 |
1966年 | 5篇 |
1965年 | 4篇 |
1961年 | 3篇 |
1960年 | 3篇 |
1959年 | 5篇 |
1957年 | 4篇 |
1955年 | 4篇 |
1954年 | 6篇 |
排序方式: 共有882条查询结果,搜索用时 0 毫秒
1.
2.
A. Fleckenstein E. Gerlach Johanna Janke P. Marmier 《Pflügers Archiv : European journal of physiology》1960,271(1):75-104
Ohne ZusammenfassungMit 7 TextabbildungenDie vorliegenden Studien am Physiologischen Institut Freiburg i. Br. wurden durch einen Bundeszuschuß des Ministeriums für Atomkernenergie und Wasserwirtschaft (Bonn) ermöglicht. Die Untersuchungen in Zürich wurden aus Mitteln des Schweizer Nationalfonds getragen. Den genannten Institutionen gilt unser besonderer Dank. Vorläufige Mitteilungen über die Methode und die hier dargestellten Ergebnisse wurden bereits früher gegeben [siehe Fleckenstein, A. E. Gerlach, u. J. Janke gemeinsam mit P. Marmier: Naturwissenschaften 46, 365 (1959); Pflügers Arch. ges. Physiol. 270, 20 (1959); P. Marmier gemeinsam mit E. Gerlach, J. Janke u. A. Fleckenstein: Pflügers Arch. ges. Physiol. 270, 19 (1959); A. Fleckenstein: University of London Special University Lectures in Physiology 26–28. Oct. 1959: The turnover rates of high energy phosphate compounds during activity and rest as indicated by the oxygen exchange with H2O18. Bericht von E. Gerlach sowie von J. Janke vor der Freiburger Med. Ges. vom 24. 11. 1959, vgl. Klin. Wschr. 38, 341–342 (1960)]. 相似文献
3.
4.
1. 2,4,7-Triamino-6-phenyl-pteridine (triamterene) protects the rat heart against isoproterenol-induced myocardial lesions: Whilst cardiotoxic doses of isoproterenol produce deleterious myocardial Ca overload, simultaneous admistration of triamterene diminishes myocardial Ca incorporation considerably. 2. As to the mechanism of action, triamterene increases the plasma contents of K and Mg by inhibiting renal excretion. Accordingly, oral administration of K and Mg salts, leading to a similar rise in the K and Mg concentrations of the plasma, also prevents abundant myocardial Ca incorporation. 3. Cardioprotection by triamterene can, in fact, be simply explained by its action on the plasma K and (particularly) Mg levels. This conclusion is drawn from a quantitative comparison of the inhibitory effects of triamterene (40 mg/kg s.c.) with those of KCl or MgCl2 (10 mMol/kg p.o.) on the isoproterenol-induced increase in myocardial 45Ca uptake and absolute Ca concentration. 4. Isoproterenol induced cardiomyopathy of the rat, an experimental model of non-coronarogenic myocardial lesions, has hitherto been successfully prevented with the use of Ca-antagonists (verapamil, D 600, prenylamine, fendiline). These compounds reduce Ca influx by restricting the Ca conductivity of the myocardial sarcolemma membrane ("slow channel"). The action of triamterene, on the other hand, is based on a totally different cardioprotective principle, namely competitive inhibition of intracellular myocardial Ca accumulation via an increase in K and Mg supply. In the future treatment of cardiomyopathy it seems rather promising to try a combination of both a Ca-antagonist and triamterene, thus applying two different therapeutic principles simultaneously. 相似文献
5.
Janke Greidanus Pax H. B. Willemse Donald R. A. Uges Evrard T. H. G. J. Oremus Zacharias J. Langen Elisabeth G. E. Vries 《Pharmacy World & Science》1988,10(6):237-245
With the recent development of reliable portable pumps and safe venous access systems, continuous infusion of chemotherapeutic agents on an out-patient basis has become feasible. Advantages of continuous infusion are the long-term exposure of tumour cells to the drug and the fact that most toxic effects are reduced for doxorubicin, epirubicin and mitoxantrone due to elimination of the high peak plasma levels. Preliminary data for doxorubicin suggest that its antitumour activity is maintained. Pharmacokinetic studies with epirubicin and mitoxantrone showed a linear relationship between drug dose infused and the steady-state plasma level for these drugs. The area under the curve for leukocytes drug level was higher during continuous infusion than after an equitoxic bolus injection of epirubicin and mitoxantrone. Well-randomized clinical trials will be necessary to investigate the role of continuous infusion of antracyclines and mitoxantrone in cancer chemotherapy in the future. 相似文献
6.
Jelle Koopsen Catharina E. van Ewijk Roisin Bavalia Akke Cornelissen Sylvia M. Bruisten Floor de Gee Alvin X. Han Maarten de Jong Menno D. de Jong Marcel Jonges Norin Khawaja Fleur M.H.P.A. Koene Mariken van der Lubben Iris Mikulic Sjoerd P.H. Rebers Colin A. Russell Janke Schinkel Anja J.M. Schreijer Judith A. den Uil Matthijs R.A. Welkers Tjalling Leenstra 《Emerging infectious diseases》2022,28(5):1012
We report a severe acute respiratory syndrome coronavirus 2 superspreading event in the Netherlands after distancing rules were lifted in nightclubs, despite requiring a negative test or vaccination. This occurrence illustrates the potential for rapid dissemination of variants in largely unvaccinated populations under such conditions. We detected subsequent community transmission of this strain. 相似文献
7.
Benjamin D. Aronson Kristin K. Janke Andrew P. Traynor 《American journal of pharmaceutical education》2012,76(7)
Objective. To develop a definition of professional engagement, a list of professionally engaging and disengaging activities, and characteristics of those activities.Methods. A 2-round modified Delphi process was conducted using student pharmacists. The first round captured input while the second assessed agreement using a 5-point Likert scale.Results. A definition was created using the 3 items that reached consensus. All engaging characteristics reached consensus, and 25% (3/12) of the disengaging characteristics reached consensus. Lower rates of consensus were observed for activities, with 78% (7/9) of the professionally engaging and none of the disengaging activities reaching consensus.Conclusion. The findings of this study have implications for creating professionally engaging learning experiences for student pharmacists and suggest that ensuring activities contain certain professionally engaging characteristics may be more important than the activities themselves. 相似文献
8.
9.
E C Vourvouri D Poldermans J J Bax G Sianos F B Sozzi A F Schinkel J de Sutter G Parcharidis R Valkema J R Roelandt 《European journal of nuclear medicine》2001,28(11):1610-1615
The objective of this study was to perform a head-to-head comparison between two-dimensional (2D) echocardiography and gated single-photon emission computed tomography (SPET) for the evaluation of left ventricular (LV) function and volumes in patients with severe ischaemic LV dysfunction. Thirty-two patients with chronic ischaemic LV dysfunction [mean LV ejection fraction (EF) 25%+/-6%] were studied with gated SPET and 2D echocardiography. Regional wall motion was evaluated by both modalities and scored by two independent observers using a 16-segment model with a 5-point scoring system (1= normokinesia, 2= mild hypokinesia, 3= severe hypokinesia, 4= akinesia and 5= dyskinesia). LVEF and LV end-diastolic and end-systolic volumes were evaluated by 2D echocardiography using the Simpson's biplane discs method. The same parameters were calculated using quantitative gated SPET software (QGS, Cedars-Sinai Medical Center). The overall agreement between the two imaging modalities for assessment of regional wall motion was 69%. The correlations between gated SPET and 2D echocardiography for the assessment of end-diastolic and end-systolic volumes were excellent (r=0.94, P<0.01, and r=0.96, P<0.01, respectively). The correlation for LVEF was also good (r=0.83, P<0.01). In conclusion: in patients with ischaemic cardiomyopathy, close and significant relations between gated SPET and 2D echocardiography were observed for the assessment of regional and global LV function and LV volumes; gated SPET has the advantage that it provides information on both LV function/dimensions and perfusion. 相似文献
10.
C. Baufreton A. Brochet H. Darrieutort J.-M. Chrétien E. Parot Schinkel M. Tanguy E. Dalmayrac J.-J. Lehot 《Annales fran?aises d'anesthèsie et de rèanimation》2013