Victim Help Seeking: Differences Between Intimate Terrorism and Situational Couple Violence

Abstract: Research indicates that two major forms of partner violence exist, intimate terrorism (IT) and situational couple violence (SCV). The current study (N= 389) used a subgroup of women who responded to the Chicago Women’s Health Risk Study to examine whether type of violence experienced is differentially related to formal (e.g., police, medical agencies, counseling) and informal (e.g., family, friends/neighbors) help seeking. IT victims were more likely to seek each type of formal help but were equally or less likely to seek informal help. Findings can inform both family violence research and the development and implementation of social service programs.     

Cross-sectional validation of the PROMIS-Preference scoring system by its association with social determinants of health

Quality of Life Research - PROMIS-Preference (PROPr) is a generic, societal, preference-based summary score that uses seven domains from the Patient-Reported Outcomes Measurement Information System...     

Hereditary Spastic Paraplegia Type 43 (SPG43) is Caused by Mutation in C19orf12

We report here the genetic basis for a form of progressive hereditary spastic paraplegia (SPG43) previously described in two Malian sisters. Exome sequencing revealed a homozygous missense variant (c.187G>C; p.Ala63Pro) in C19orf12, a gene recently implicated in neurodegeneration with brain iron accumulation (NBIA). The same mutation was subsequently also found in a Brazilian family with features of NBIA, and we identified another NBIA patient with a three‐nucleotide deletion (c.197_199del; p.Gly66del). Haplotype analysis revealed that the p.Ala63Pro mutations have a common origin, but MRI scans showed no brain iron deposition in the Malian SPG43 subjects. Heterologous expression of these SPG43 and NBIA variants resulted in similar alterations in the subcellular distribution of C19orf12. The SPG43 and NBIA variants reported here as well as the most common C19orf12 missense mutation reported in NBIA patients are found within a highly conserved, extended hydrophobic domain in C19orf12, underscoring the functional importance of this domain.     

A Voice-Based Computer Interview for Drug Dependence

Abstract

The Recovery Attitudes and Treatment Evaluator (RAATE), via 94 true/false questions, assesses resistance and obstacles to chemical dependence treatment. We computerized the RAATE to offer questions via digitized human voice and to recognize patient responses spoken into the computer's microphone. Sixty-eight consecutive adults seeking addictions treatment were randomized to one of four formats. The voice-input/voice-output version yielded the shortest mean duration of administration. Patients reported high satisfaction ratings and confidence that their answers were accurate. They perceived their responses to be useful in treatment planning. Group mean ratings did not significantly differ by version. There was a statistical trend in which the voice-based versions reduced the intragroup variability on test duration and patient confidence. Computerized voice-interactive interviewing may shorten test durations, increase the uniformity of administration, increase access for the vision-impaired, and increase the data entry efficiency and accuracy. The method provides a consistent, controlled, and nonjudgmental interview interaction.     

Report of nationally representative values for the noninstitutionalized US adult population for 7 health-related quality-of-life scores.

BACKGROUND: Despite widespread use of generic health-related quality-of-life (HRQoL) scores, few have publicly published nationally representative US values. PURPOSE: To create current nationally representative values for 7 of the most common HRQoL scores, stratified by age and sex. METHODS: The authors used data from the 2001 Medical Expenditures Panel Survey (MEPS) and the 2001 National Health Interview Survey (NHIS), nationally representative surveys of the US noninstitutionalized civilian population: The MEPS was used to calculate 6 HRQoL scores: categorical self-rated health, EuroQoL-5D with US scoring, EuroQoL-5D with UK scoring, EuroQol Visual Analog Scale, mental and physical component summaries from the SF-12, and the SF-6D. The authors estimated Quality of Well-being scale scores from the NHIS. RESULTS: They included 22,523 subjects from MEPS 2001 and 32,472 subjects from NHIS 2001. Most age and sex categories had instrument completion rates above 85%. Females reported lower scores than males across all ages and instruments. In general, those in older age groups reported lower scores than younger age groups, with the exception of the mental component summary from the SF-12. CONCLUSION: This is one of the first sets of publicly available, nationally representative US values for any standardized HRQoL measure. These values are important for use in both generalized comparisons of health status and in cost-effectiveness analyses.     

Coaching for competence.

The preceptors and leadership team on a busy acute care general medical unit collaborated on a temporary plan to provide clinical support for 38 nurses who had been hired during the year. A pilot role was created and designated "unit coach." Each coach questioned and prompted reflective practice in building confidence and critical thinking.     

Hyperkeratosis in cystathionine beta synthase-deficient mice: an animal model of hyperhomocysteinemia

Cystathionine beta synthase (CBS) is a crucial regulator of plasma concentrations of homocysteine. Severe hyperhomocysteinemia due to CBS deficiency confers diverse clinical manifestations. Patients with severe hyperhomocysteinemia have fine hair and thin skin, but it is unclear whether these changes are related to CBS deficiency or are coincidental. To investigate these aspects of hyperhomocysteinemia, we characterized skin abnormalities of CBS-deficient mice, a murine model of severe hyperhomocysteinemia. Histological and histomorphometric analyses revealed that CBS-deficient mice have wrinkled skin with hyperkeratinosis of the epidermis and thinning of the dermis.