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1.
Erika Cecon Anna Ivanova Marine Luka Florence Gbahou Anne Friederich Jean‐Luc Guillaume Patrick Keller Klaus Knoch Raise Ahmad Philippe Delagrange Michele Solimena Ralf Jockers 《Journal of pineal research》2019,66(2)
Melatonin receptors play important roles in the regulation of circadian and seasonal rhythms, sleep, retinal functions, the immune system, depression, and type 2 diabetes development. Melatonin receptors are approved drug targets for insomnia, non‐24‐hour sleep‐wake disorders, and major depressive disorders. In mammals, two melatonin receptors (MTRs) exist, MT1 and MT2, belonging to the G protein‐coupled receptor (GPCR) superfamily. Similar to most other GPCRs, reliable antibodies recognizing melatonin receptors proved to be difficult to obtain. Here, we describe the development of the first monoclonal antibodies (mABs) for mouse MT1 and MT2. Purified antibodies were extensively characterized for specific reactivity with mouse, rat, and human MT1 and MT2 by Western blot, immunoprecipitation, immunofluorescence, and proximity ligation assay. Several mABs were specific for either mouse MT1 or MT2. None of the mABs cross‐reacted with rat MTRs, and some were able to react with human MTRs. The specificity of the selected mABs was validated by immunofluorescence microscopy in three established locations (retina, suprachiasmatic nuclei, pituitary gland) for MTR expression in mice using MTR‐KO mice as control. MT2 expression was not detected in mouse insulinoma MIN6 cells or pancreatic beta‐cells. Collectively, we report the first monoclonal antibodies recognizing recombinant and native mouse melatonin receptors that will be valuable tools for future studies. 相似文献
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Peffault de Latour Rgis Huynh Lynn Ivanova Jasmina I. Totev Todor Bilginsoy Mehmet Antin Joseph Roy Anuja Duh Mei Sheng 《Annals of hematology》2020,99(4):743-752
Annals of Hematology - This study assessed treatment patterns and healthcare resource utilization (HRU) of patients with severe aplastic anemia (SAA) with insufficient response to immunosuppressive... 相似文献
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M Iu Barantseva L N Mukhamedieva B S Fedorenko S M Ivanova A A Pakhomova S V Vorozhtsova 《Aviakosmicheskaia i ekologicheskaia meditsina》2007,41(2):54-60
Combined exposure of mice to a mixture of chemicals in small quantities and gamma-radiation at a total dose of 30 sGy cause partial summation of biological effects assessed by cytogenetic disorders in nuclear cells of the bone marrow and changes in erythrocyte metabolism. The level of cytogenetic damages in bone marrow cells remained increased till day 14 of recovery, whereas following exposure to chemicals or radiation alone the number of chromosomal aberrations (ChA) was nearly same as in control at this point of recovery The anaphase method showed prevalence of ChA in the form of fragments over bridges in marrow karyocites. The combination of factors suppressed energy-producing processes in erythrocytes (reliable reductions in lactate dehydrogenase and lactate) and activated oxidation processes (reliable decrease in reduced glutathione). Functional shifts in erythrocyte metabolism persisted till day 30 of recovery Based on results of the investigation, functional status of organism following low-intensity exposures can be assessed, along with cytogenetic, also by indices of erythrocyte metabolism. 相似文献
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Inclusion of ketonazole (in a daily dose of 400 mg/kg for 8 days) into the diet of intact and cholesterol-fed (5% dietary cholesterol) rats produced a respective 20- and 30-percent lowering of cholesterol content in blood serum. In all the animals, the hypocholesterolemic effect of ketoconazole was realized via a decrease of the concentration of very low and low density lipoproteins. Ketoconazole also gave rise to a reduction of the concentration of cholesterol and bile acids in bile of the intact rats and of cholesterol in bile of the cholesterol-fed animals. 相似文献