排序方式: 共有8条查询结果,搜索用时 15 毫秒
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Marzieh JABBARZARE Voon Kin CHIN Herni TALIB Mun Fei YAM Siti Khadijah ADAM Haniza HASSAN Roslaini ABDUL MAJID Che Norma MAT TAIB Mohamad Aris MOHD MOKLAS Mohamad TAUFIK HIDAYAT Hasidah MOHD SIDEK Rusliza BASIR 《Iranian Journal of Parasitology》2015,10(3):389-401
Background: Interleukin 18 (IL-18) exerts pleiotropic roles in many inflammatory-related diseases including parasitic infection. Previous studies have demonstrated the promising therapeutic potential of modulating IL-18 bioactivity in various pathological conditions. However, its involvement during malaria infection has yet to be established. In this study, we demonstrated the effect of modulating IL-18 on the histopathological conditions of malaria infected mice.
Methods:
Plasmodium berghei ANKA infection in male ICR mice was used as a model for malaria infection. Modulation of IL-18 release was carried out by treatment of malarial mice with recombinant mouse IL-18 (rmIL-18) and recombinant mouse IL-18 Fc chimera (rmIL-18Fc) intravenously. Histopathological study and analysis were performed on major organs including brain, liver, spleen, lungs and kidney.
Results: Treatment with rmIL-18Fc resulted in significant improvements on the histopathological conditions of the organs in malaria-infected mice.
Conclusion: IL-18 is an important mediator of malaria pathogenesis and targeting IL-18 could prove beneficial in malaria-infected host.Key Words: Malaria, Interleukin-18, Plasmodium berghei, Histopathology 相似文献
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Objective
The aim of this study was to examine prior studies relating to carers’ needs from mental health services for their own wellbeing.Method
A systematic approach was adopted for the literature review. The databases searched included MEDLINE, PSycINFO, EMBASE, and CINAHL, involving the use of search terms such as carers, mental health, and needs. The search was conducted in April 2012 and updated in December 2015. In total, 40 published papers were included in the review and were subsequently assessed for quality. For the data synthesis, a thematic analysis approach was employed to integrate the quantitative and qualitative evidence relating to carers’ needs.Results
Twenty-five of the reviewed studies were qualitative, 12 were quantitative, and 3 were mixed. Four major carer needs emerged from the synthesis: (1) holistic wellbeing of service users, (2) holistic wellbeing of carers, (3) supportive attitudes of professionals, and (4) carer involvement. All four of these needs, in fact, revolved around the carers’ ill relatives.Conclusions
The studies reviewed suggest that while carers of people suffering from mental illness have a range of needs, they generally fail to offer straightforward information about their own needs. 相似文献4.
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AHMED KARIM TALIB M.D. Ph.D. NOBUYUKI SATO M.D. Ph.D. NAOKO KAWABATA M.D. EITARO SUGIYAMA M.D. NAKA SAKAMOTO M.D. YASUKO TANABE M.D. Ph.D. TAKAYUKI FUJINO M.D. Ph.D. TOSHIHARU TAKEUCHI M.D. YASUAKI SAIJO M.D. Ph.D. KAZUMI AKASAKA M.D. Ph.D. YUICHIRO KAWAMURA M.D. Ph.D. NAOYUKI HASEBE M.D. Ph.D. 《Journal of cardiovascular electrophysiology》2014,25(12):1376-1384
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AHMED KARIM TALIB M.D. NOBUYUKI SATO M.D. Ph.D. NAKA SAKAMOTO M.D. YASUKO TANABE M.D. Ph.D. TOSHIHARU TAKEUCHI M.D. YASUAKI SAIJO M.D. Ph.D. YUICHIRO KAWAMURA M.D. Ph.D. NAOYUKI HASEBE M.D Ph.D. 《Journal of cardiovascular electrophysiology》2012,23(10):1109-1114
J Wave Syndromes . Introduction: Recently, great attention has been paid to the risk stratification of asymptomatic patients with an electrocardiographic early repolarization (ER) pattern. We investigated several repolarization parameters including the Tpeak‐Tend interval and Tpeak‐Tend/QT ratio in healthy individuals and patients with J wave syndrome who were aborted from sudden cardiac death. Methods and Results: Ninety‐two subjects were enrolled: 12 patients with ventricular fibrillation associated with J waves, 40 healthy subjects with an uneventful ER pattern and 40 healthy control subjects (C) without any evident J waves. Using ambulatory electrocardiogram recordings, the average QT interval, corrected QT interval (QTc), Tpeak‐Tend (Tp‐e) interval, which is the interval from the peak to the end of the T wave, and Tp‐e/QT ratio were calculated. Using ANOVA and post hoc analysis, there was no significant difference in the average QT and QTc in all 3 groups (QT; 396 ± 27 vs 405 ± 27 vs 403 ± 27 m, QTc; 420 ± 26 vs 421 ± 21 vs 403 ± 19 milliseconds in the C, ER pattern and J groups, respectively). The Tp‐e interval and Tp‐e/QT ratio were significantly more increased in the J wave group than the ER Pattern group (Tp‐e: 86.7 ± 14 milliseconds vs 68 ± 13.2 milliseconds, P < 0.001, Tp‐e/QT; 0.209 ± 0.04 vs 0.171 ± 0.03, P < 0.001), but they did not significantly differ between the C and ER pattern groups (Tp‐e: 68.6 ± 7.5 vs 68 ± 13.2, P = 0.97, Tp‐e/QT 0.174 ± 0.02 vs 0.171 ± 0.03, P = 0.4). Conclusion: As novel markers of heterogeneity of ventricular repolarization, Tpeak‐Tend interval and Tp‐Te/QT ratio are significantly increased in patients with J wave syndromes compared to age and sex‐matched uneventful ER. (J Cardiovasc Electrophysiol, Vol. 23 pp. 1109‐1114, October 2012) 相似文献
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Objective
The research identified the influence of assertiveness training against teenage depression in high scholars in Kepahiang Regency, Bengkulu, Indonesia.Method
This study used a quasi-experiment approach with pre-test and post-test design and a control group. Eighty students were engaged through simple random sampling.Results
The study found the frequency of depression in teenagers and considered the effect of assertiveness training. 14.10 teens were counted as depressed before assertiveness training provision, while the post-training average was 7.98 (p = .000). Assertiveness training had a significant effect on the prevalence of depression in the intervention group.Conclusions
The study recommends schools to cooperate with health services to increase mental health programs such as building peer groups, delivering assertiveness training, and teaching stress management to prevent depression in teenagers. 相似文献8.
AHMED KARIM TALIB M.D. Ph.D. NOBUYUKI SATO M.D. Ph.D. AKIRA ASANOME M.D. TAKUYA MYOJO M.D. TAKESHI NISHIURA M.D. MASARU YAMAKI M.D. NAOKI NAKAGAWA M.D. Ph.D. NAKA SAKAMOTO M.D. HISANOBU OTA M.D. YASUKO TANABE M.D. Ph.D. TOSHIHARU TAKEUCHI M.D. YUICHIRO KAWAMURA M.D. Ph.D. NAOYUKI HASEBE M.D. Ph.D. 《Journal of cardiovascular electrophysiology》2013,24(5):556-561
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