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1.
International Journal of Clinical Pharmacy - 相似文献
2.
Joost P. Bruijntjes C. Frieke Kuper Joke E. Robinson Henk-Jan Schuurman 《Clinical & developmental immunology》1993,3(2):113-122
The histology of epithelium-free areas in the subcapsular region of the thymus was
studied in Wistar rats. Lymphocytes in these areas were CD4/CD8 double-positive, TCR
α/β positive in low intensity, and in CD5 labeling either negative or positive in low
intensity. There was a high proliferative activity as assessed by bromodeoxyuridine
incorporation in vivo and detected by immunohistochemistry. Various macrophage
types were observed. They were either large and round to slightly dendritic, or small
and dendritic. Most large cells were positive for MHC Class II, and labeled by the
antimacrophage antibodies ED1 and ED2. A few cells were strongly positive for Sudan
black, Oil red O, nonspecific esterase, and acid phosphatase; they resembled the large
rounded macrophages in the corticomedullary zone, although their MHC Class II and
ED2 staining was more intense. A few cells showed features of tingible body
macrophages, as they contained cellular debris.Serial sections showed that epithelium-free areas run from the subcapsular area to
deep in the cortex, and often border the medulla. This opens the opportunity for
immature lymphocytes to move into the medulla and corticomedullary zone without
contacting and potential selection with cortical stromal elements other than
macrophages in the epithelium-free areas. In this case, the epithelium-free areas may
offer a separate intrathymic pathway for T lymphocytes. 相似文献
3.
Boersema Henk-Jan Hoekstra Tialda Abma Femke Brouwer Sandra 《Journal of occupational rehabilitation》2021,31(4):796-806
Journal of Occupational Rehabilitation - Purpose Inability to work fulltime is an important outcome in the assessment of workers applying for a disability benefit. However, limited knowledge is... 相似文献
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Martin Gotthardt Decio L. Eizirik Henk-Jan Aanstoot Olle Korsgren Dick Mul Frank Martin Marti Boss Tom J. P. Jansen Sanne A. M. van Lith Mijke Buitinga Olof Eriksson Miriam Cnop Maarten Brom 《Diabetologia》2018,61(12):2516-2519
In this issue of Diabetologia, Alavi and Werner ( https://doi.org/10.1007/s00125-018-4676-1) criticise the attempts to use positron emission tomography (PET) for in vivo imaging of pancreatic beta cells, which they consider as ‘futile’. In support of this strong statement, they point out the limitations of PET imaging, which they believe render beta cell mass impossible to estimate using this method. In our view, the Alavi and Werner presentation of the technical limitations of PET imaging does not reflect the current state of the art, which leads them to questionable conclusions towards the feasibility of beta cell imaging using this approach. Here, we put forward arguments in favour of continuing the development of innovative technologies enabling in vivo imaging of pancreatic beta cells and concisely present the current state of the art regarding putative technical limitations of PET imaging. Indeed, far from being a ‘futile’ effort, we demonstrate that beta cell imaging is now closer than ever to becoming a long-awaited clinical reality. 相似文献
6.
Henk-Jan Schuurman W. Slingerland Klaus Mennninger Miriam Ossevoort Jean-Claude Hengy Birgit Dorobek Jacky Vonderscher Jan Ringers Mamoun Odeh Margreet Jonker 《Transplant international》2001,14(5):320-328
In cynomolgus and rhesus monkeys, the dose-normalized exposure of cyclosporine administered orally as microemulsion preconcentrate
(Neoral) was lower than that upon intramuscular administration. For oral administration, mean values ( ± SD) of Cmax, 24-h area-under-the curve (AUC) and 24-h trough level, all normalized for a 1 mg/kg dose, were 20 ± 9 ng kg/mg ml, 210 ±
70 ng h kg/mg ml and 2.6 ± 0.9 ng kg/mg ml, respectively. For intramuscular administration, levels were about 5.5-fold, 9-fold
and 22-fold higher. Based on pharmacokinetic data, the efficacy of oral cyclosporine treatment (without any other immunosuppressant)
was evaluated in life-supporting cynomolgus monkey kidney allotransplantation. Rejection-free kidney allograft survival could
be achieved using oral cyclosporine monotherapy with average 24-h trough concentrations above 100 ng/ml during maintenance
treatment. Typically, daily oral doses of 100 mg/kg–150 mg/kg during the first two weeks post-transplantation, followed by
daily 30 mg/kg–100 mg/kg dose levels during subsequent maintenance can result in long-term allograft survival, with 24-h average
trough levels in individual animals during maintenance between 110 ng/ml and 700 ng/ml.
Received: 1 October 1997 Revised: 20 April 2001 Accepted: 7 June 2001 相似文献
7.
Van der Woude HJ Hazelbag HM Bloem JL Taminiau AH Hogendoorn PC 《AJR. American journal of roentgenology》2004,183(6):1737-1744
OBJECTIVE: The purposes of this retrospective study were to assess specific MRI features of adamantinoma, including classic adamantinoma and its osteofibrous dysplasia-like variant, and to assess the role of adamantinoma in surgical planning. MATERIALS AND METHODS: MR images of 22 patients with histologically proven adamantinoma, subtyped according to defined criteria, were analyzed, with emphasis on morphologic features, signal intensities, and enhancement parameters. Intra- and extraosseous tumor extent was determined. In all patients, examination of the corresponding resected specimens was performed with regard to tumor extent and presence of multicentricity. Moreover, radiographs were reviewed, and radiographic features derived from the literature were determined. RESULTS: All tumors were primarily localized in the tibia diaphysis (including one patient with additional lesions in the fibula), most frequently in the anterior cortical bone (19/22) with extension toward the bone marrow in 12 patients. We distinguished two morphologic patterns: a solitary lobulated focus versus a pattern of multiple small nodules in one or more foci. Separated tumor foci, defined as foci of high signal intensity on either T2-weighted images or T1-weighted contrast-enhanced images, interspersed with normal-appearing cortical or spongious bone were seen in six patients. All tumors showed intense and homogeneous static enhancement, but there was no uniform dynamic enhancement pattern. No relationship between MRI features and histologic subtype of adamantinoma was found. CONCLUSION: Some uniform MRI characteristics, along with those of radiography, may contribute to the diagnosis of adamantinoma; however, these are not related to the histologic subtype. MRI is pivotal for precise locoregional staging, especially for depiction of distant cortical foci, soft tissue, and intramedullary extension and thus is useful for determining tumor-free margins and strategies for reconstructive surgery. 相似文献
8.
BACKGROUND: In vivo xenotransplantation modeling in large animal species is often performed in nonhuman primates, including baboons. For proper data interpretation, reference values for clinical chemistry and hematology are required. METHODS: These values are available from baseline levels in animals subjected to tolerability/pharmacokinetic studies. For each individual study two tests for clinical chemistry and hematology were performed before the start of treatment. RESULTS AND CONCLUSION: We present such data from 17 male and 16 female baboons, with body weights ranging between 4.4 and 14.0 kg (males) and 4.1 and 15.0 kg (females), respectively. The number of duplicate samples per animal determined before each individual study ranged between one and five. These data are reported here to provide baseline values for veterinarians and investigators using baboons in experimental studies, particularly in xenotransplantation. 相似文献
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10.
Hannon JP Tigani B Schuurman HJ Fozard JR 《The Journal of pharmacology and experimental therapeutics》2002,302(2):725-730
Dexamethasone increases the expression of adenosine A(3) receptors and augments degranulation in response to their activation in the rat basophilic leukemia cell line, RBL-2H3. We have studied the effects of dexamethasone on mast cell activation induced by A(3) receptor stimulation in vivo. Administration of the A(3) receptor agonist APNEA [N(6)-2-(4 aminophenyl)ethyladenosine; 10-30 microg kg(-1) i.v.] to anesthetized Sprague-Dawley rats induced falls in blood pressure. Pretreatment with dexamethasone (1 mg kg(-1), i.p., -24 h) blocked the hypotensive response to APNEA but not those induced by the A(1) receptor agonist N(6)-cyclopentyladenosine, the A(2A) receptor agonist 2-[p-(2-carboxyethyl)phenylamino]-5'-N-ethylcarboxamidoadenosine, or the mast cell degranulating agent compound 48/80 (100-300 microg kg(-1), i.v.). APNEA (10 and 30 microg kg(-1), i.v.) and compound 48/80 (100 and 300 microg kg(-1), i.v.) increased plasma histamine concentrations dose dependently. Pretreatment with dexamethasone significantly inhibited the increases induced by the lower doses of each compound. APNEA induced degranulation of mast cells in thymus but not in skin or skeletal muscle, whereas compound 48/80 induced degranulation in each tissue. Pretreatment with dexamethasone inhibited APNEA-induced degranulation of mast cells in the thymus and slightly, yet significantly, reduced degranulation induced by compound 48/80. Thus, in contrast to the findings in RBL-2H3 cells in vitro, in the whole animal, dexamethasone down-regulates the response of the mast cell to A(3) receptor activation. The qualitatively similar effects on compound 48/80 suggest that dexamethasone suppresses mast cell responsiveness by modulating site(s) downstream from the adenosine A(3) receptor, possibly at the level of the G(i) family of trimeric GTP-binding proteins. 相似文献