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1.
INTRODUCTIONThemaintreatmenttodateforovariancarcinomaissurgicalresection,thesocalledcytoreductivesurgery.Toperformacompleteresection,surgeonsusuallydependonvisualandtactilesensesaswellassurgicalinstinctswhicharerelativelycrudeinidentifyingsubclinicalmicroscopictumor.Radioimmuno--guidedsurgerysystem(RIGS)hasbeentakenoverthelast10yearsinbothlaboratoryandclinicalsettings.However,onlyafewreportswereseenaboutitsstudyinovariancancerworldwideespeciallyinourcountry.OurstudyincludeestablishingaR… 相似文献
2.
Gordon A Francis Gang Li Robin Casey Jian Wang Henian Cao Todd Leff Robert A Hegele 《BMC medical genetics》2006,7(1):3-7
Background
Familial partial lipodystrophy (Dunnigan) type 3 (FPLD3, Mendelian Inheritance in Man [MIM] 604367) results from heterozygous mutations in PPARG encoding peroxisomal proliferator-activated receptor-γ. Both dominant-negative and haploinsufficiency mechanisms have been suggested for this condition. 相似文献3.
空肠弯曲菌HSP43诱导自身免疫机理──分子模拟和抗原优势 总被引:3,自引:0,他引:3
我们曾发现空肠弯曲菌43kD热休克蛋白(HSP43)能诱导小鼠产生自身免疫应答,本文则进一步分析了这种诱导作用的机理。二株针对HSP60保守区序列的单克隆抗体IIH9和ML-30不但能结合人及小鼠细胞中HSP60家族成员,而且也能结合HSP43,表明HSP43、人及小鼠HSP60三者均属同一家族成员,具有序列上的高度同源性。小鼠用空肠弯曲菌免疫后出现了针对10种菌体蛋白的抗体,其中最早被诱导的抗体是针对HSP43的,并且该种抗体在随后80d观察期间内保持了较高活性,表明HSP43是优势抗原。本文结果提示,HSP43较易被免疫系统识别而产生应答,通过和宿主HSP60高度序列同源性而可能呈现分子模拟,从而诱导自身免疫损伤。 相似文献
4.
Because mutations in human SHP1 underlie obesity and diabetes, SHP1 is a candidate gene for human lipodystrophy syndromes. To identify possible disease mutations and/or common single-nucleotide
polymorphisms (SNPs), we developed primer pairs to amplify the promoter and coding region of SHP1. We used these pairs to sequence SHP1 in lipodystrophy patients who had no mutations in known lipodystrophy genes, and also in normal control subjects. We found
no rare SHP1 coding sequence variants that were exclusive to patients with lipodystrophy. However, we found four polymorphisms, namely,
an SNP [−394]C>T in the promoter, a micro-deletion polymorphism [−195]delCTGA in the promoter, a missense SNP 541G>C in exon
1 (which changed the amino acid sequence G171A), and an SNP 903C>T in exon 2. The findings suggest that SHP1 mutations are not commonly seen in patients with lipodystrophy who had no mutations in known disease genes. However, the identification
of amplification primers and polymorphisms provides tools to further investigate SHP1 for association with other phenotypes.
Received: April 1, 2002 / Accepted: April 22, 2002 相似文献
5.
目的:观察半夏泻心汤加减治疗肝胃不和证反流性食管炎合并反酸的临床疗效及对血清胃泌
素(GAS)、胃动素(MLT) 水平的影响。方法:选取80 例肝胃不和证反流性食管炎合并反酸患者,随机分为
研究组和对照组各40 例。对照组给予常规治疗,研究组在对照组基础上结合半夏泻心汤加减治疗。比较2 组
疗效,以及治疗前后中医证候评分及GAS、MLT 水平。结果:研究组总有效率为92.5%,对照组为75.0%,
2 组比较,差异有统计学意义(P<0.05)。治疗前,2 组呃逆嗳气、吞酸烧心、胸胁胀满、情志抑郁等中医证
候评分比较,差异无统计学意义(P>0.05);治疗后,2 组上述各项中医证候评分均较治疗前降低(P<
0.05),且研究组各项评分均低于对照组(P<0.05)。治疗前,2 组GAS、MLT 水平比较,差异无统计学意
义(P>0.05);治疗后,2 组GAS、MLT 水平均较治疗前升高(P<0.05),且研究组GAS、MLT 水平均高于对
照组(P<0.05)。结论:半夏泻心汤加减治疗肝胃不和证反流性食管炎合并反酸疗效显著,有助于改善患者中
医证候,增强胃肠运动功能。 相似文献
6.
卵巢上皮性癌155例的治疗与预后 总被引:11,自引:0,他引:11
目的:探讨卵巢上皮性癌的治疗与影响预后的因素。方法:对1970年1月至1992年12月在我院治疗的155例卵巢上皮性癌进行回顾性分析。全部手术切除标本经病理检查诊断并按FIGO分期标准进行分期,42例行2次手术,4例行3次手术。除6例外,余149例均于手术后行化疗,32例于第2次术后再次行化疗,9例因复发再次化疗。结果:2年、5年、10年的生存率分别为Ⅰ期92.4%、87.0%、70.6%;Ⅱ期91.9%、63.6%、47.8%;Ⅲ期59.9%、38.2%、19.2%;Ⅳ期25.0%、25.0%、0.0%(P<0.001)。6例未化疗者均在术后2年内死亡。结果表明,预后与临床分期、细胞分化、残留癌灶大小有关。5年生存率中,Ⅰ期为87.0%和Ⅲ期为38.2%(P<0.001);G1的5年生存率为95.9%,G3为11.8%(P<0.001);无残留癌灶者为97.6%,残留癌灶>2cm者为21.2%(P<0.001)。结论:在卵巢上皮性癌初次手术时残留癌灶<2cm,并于术后尽早开始化疗,可提高生存率。 相似文献
7.
目的:总结三分支主动脉弓覆膜支架治疗Stanford A型主动脉夹层的临床经验。方法:2009年3月至2011年4月,13例Stanford A型主动脉夹层患者在体外循环下先进近心端操作,降温至20℃,停循环,选择性脑灌注,经无名动脉近端升主动脉横断切口,采用三分支主动脉弓覆膜支架重建主动脉弓,主干支架血管近端与替换近端升主动脉的人造血管端端吻合,主动脉根部用自体心包片与右房建立分流,出院复查心脏彩超和主动脉电子束CT。结果:所有患者术中均顺利植入三分支主动脉弓覆膜支架,体外循环时间(221.33±37.98)min,心肌阻断时间(124.77±50.00)min,停循环时间(28.38±8.12)min,选择性脑灌注时间(19.30±9.57)min。术后早期死亡1例,死因分别为不完全肠梗阻以及急性缺血性脑病,最终引起多器官功能衰竭。出院时复查主动脉电子束CT提示:主干支架血管及分支血管通畅,无扭曲,主动脉弓和胸降主动脉假腔部分血栓形成。结论:采用三分支主动脉弓覆膜支架治疗Stanford A型主动脉夹层可简化主动脉弓部手术,降低手术风险,适合于人多数Stanford A型主动脉夹层患者的治疗,长期效果尚需进一步观察。 相似文献
8.
卵巢癌单抗放免显像(RID应用于临床术前诊断已有十多年历史,我们用自制单抗^131I标记后RⅡ敏感性94.7%,特异性89.7%。在追踪治疗后的患者中,发现Ⅲ期进行过RⅡ患者,三年生存率较未进行过者延长,分别为63.49%及25%。两组在临床分期,病理类型、分级、手术方法、化疗方案等均大致相同。 相似文献
9.
Cohen P Chen H Kasen S Johnson JG Crawford T Gordon K 《Development and psychopathology》2005,17(2):549-568
Cluster A odd or eccentric personality disorder (PD) symptoms may reflect a schizophrenia spectrum biological vulnerability in at least some persons. Consequently, this symptom pattern may have particularly negative effects on the transition from adolescent to adult roles. A general population sample of 200 young adults was assessed on Cluster A PD at mean ages 17 and 22, and subsequently provided detailed narratives about their monthly experiences and behaviors between these two ages. Adolescent Cluster A PD was related to the developmental trajectories of residential, career, financial, romantic, and family formation roles during this period, and trajectories were related to a change in symptoms over this period. Symptoms were associated with early parenthood and less advanced education, but for other developmental outcomes tended to differ for men and women. These gender differences were attributable, in part, to the differential meaning and consequences of early parenthood for men and women. 相似文献
10.
A single nucleotide polymorphism in protein tyrosine phosphatase PTP-1B is associated with protection from diabetes or impaired glucose tolerance in Oji-Cree 总被引:11,自引:0,他引:11
Mok A Cao H Zinman B Hanley AJ Harris SB Kennedy BP Hegele RA 《The Journal of clinical endocrinology and metabolism》2002,87(2):724-727
Several lines of evidence support a role for protein tyrosine phosphatase 1B (PTP-1B) in metabolism, and specifically in insulin sensitivity and obesity. We report the development of reagents for the amplification and sequencing of the PTP-1B gene, which has resulted in the identification of a novel single nucleotide polymorphism (SNP), designated 981C-->T. We found a significant association between this SNP and the risk of either impaired glucose tolerance (IGT) or type 2 diabetes in the Oji-Cree of Sandy Lake, Ontario, Canada. Six hundred and fifty-three subjects were genotyped using PCR amplification of exon 8, followed by digestion with the restriction enzyme AvaI. Sixty-eight subjects were heterozygotes, and none was a homozygote. Thus, the overall frequencies of the C allele and the T allele were 0.948 and 0.052, respectively. Subjects with the PTP-1B 981T/981C genotype were approximately 40% less likely to have IGT or diabetes as subjects with the 981C/981C genotype (P = 0.040). There was no difference in quantitative traits among subjects grouped according to the PTP-1B 981C-->T SNP genotype. These very preliminary findings suggest that genomic variation in PTP-1B is associated with a reduced risk of diabetes and are consistent with the idea that this protein is important in metabolism. 相似文献