全文获取类型
收费全文 | 6838篇 |
免费 | 752篇 |
国内免费 | 31篇 |
专业分类
耳鼻咽喉 | 103篇 |
儿科学 | 315篇 |
妇产科学 | 203篇 |
基础医学 | 936篇 |
口腔科学 | 139篇 |
临床医学 | 1048篇 |
内科学 | 1478篇 |
皮肤病学 | 104篇 |
神经病学 | 384篇 |
特种医学 | 480篇 |
外国民族医学 | 2篇 |
外科学 | 662篇 |
综合类 | 96篇 |
一般理论 | 12篇 |
预防医学 | 854篇 |
眼科学 | 57篇 |
药学 | 369篇 |
中国医学 | 3篇 |
肿瘤学 | 376篇 |
出版年
2023年 | 72篇 |
2021年 | 92篇 |
2020年 | 84篇 |
2019年 | 91篇 |
2018年 | 145篇 |
2017年 | 94篇 |
2016年 | 127篇 |
2015年 | 141篇 |
2014年 | 186篇 |
2013年 | 247篇 |
2012年 | 243篇 |
2011年 | 273篇 |
2010年 | 184篇 |
2009年 | 192篇 |
2008年 | 298篇 |
2007年 | 303篇 |
2006年 | 260篇 |
2005年 | 235篇 |
2004年 | 260篇 |
2003年 | 214篇 |
2002年 | 199篇 |
2001年 | 205篇 |
2000年 | 232篇 |
1999年 | 175篇 |
1998年 | 147篇 |
1997年 | 143篇 |
1996年 | 130篇 |
1995年 | 113篇 |
1994年 | 117篇 |
1993年 | 105篇 |
1992年 | 157篇 |
1991年 | 143篇 |
1990年 | 157篇 |
1989年 | 174篇 |
1988年 | 144篇 |
1987年 | 141篇 |
1986年 | 137篇 |
1985年 | 145篇 |
1984年 | 80篇 |
1983年 | 76篇 |
1982年 | 66篇 |
1981年 | 76篇 |
1980年 | 54篇 |
1979年 | 74篇 |
1978年 | 63篇 |
1977年 | 70篇 |
1976年 | 57篇 |
1975年 | 50篇 |
1974年 | 66篇 |
1973年 | 44篇 |
排序方式: 共有7621条查询结果,搜索用时 15 毫秒
1.
2.
Lisa A. Lang DDS MS David C. Holmes DDS MS Craig Passon DDS MS Robert M. Trombly DDS JD Jeffrey D. Astroth DDS MSPH Arnold F. Tavel DMD 《Journal of prosthodontics》2003,12(3):206-210
Using complete denture treatment as an introduction to clinical patient care for dental students, the purposes of the Complete Denture Prosthodontics Transition Clinic at the University of Colorado School of Dentistry are to reduce the time lapse between the preclinical complete denture prosthodontics course and the first denture patient experience, and to encourage development of student self-confidence and skills. In the 2002 spring semester, faculty at the University of Colorado School of Dentistry initiated the Complete Denture Prosthodontics Transition Clinic for DS-II (second-year) dental students, as an introduction to clinical patient care. Each patient was assigned to a team of two dental students. Three Division of Prosthodontics faculty members staffed each clinic session, providing a student-to-faculty ratio of approximately 6.6:1 and a patient-to-faculty ratio of approximately 3.3:1. All DS-II students in the Class of 2004 delivered their first complete dentures no later than 8 months (average, 184 days) after the last day of the preclinical complete denture prosthodontics course. The time from the diagnostic appointment through the denture placement appointment averaged 39 days for patients treated in this program, compared with an average of 98 days or more for previous classes. The program was successful in achieving the goal of reducing the time lapse between the preclinical complete denture prosthodontics course and the first denture patient experience. 相似文献
3.
Intracranial venous thrombosis has been described in newborns, but there have been no reports of intractable neonatal seizures due to this condition. We report cortical venous sinus thrombosis in two term neonates who presented with seizures in the first 24 hours of life. The diagnosis was made by cranial computed tomography and was confirmed by cerebral angiography. Both patients improved clinically after the intracranial venous thrombosis resolved. These patients demonstrate that intracranial venous thrombosis should be considered in the differential diagnosis of neonatal seizures. 相似文献
4.
Allergic autoimmune reaction after exposure to heavy metals such as mercury may play a causal role in autism, a developmental disorder of the central nervous system. As metallothionein (MT) is the primary metal-detoxifying protein in the body, we conducted a study of the MT protein and antibodies to metallothionein (anti-MT) in normal and autistic children whose exposure to mercury was only from thimerosal-containing vaccines. Laboratory analysis by immunoassays revealed that the serum level of MT did not significantly differ between normal and autistic children. Furthermore, autistic children harboured normal levels of anti-MT, including antibodies to isoform MT-I (anti-MT-I) and MT-II (anti-MT-II), without any significant difference between normal and autistic children. Our findings indicate that because autistic children have a normal profile of MT and anti-MT, the mercury-induced autoimmunity to MT may not be implicated in the pathogenesis of autism. 相似文献
5.
6.
Quantification of Basal and Stimulated ROS Levels as Predictors of Islet Potency and Function 总被引:2,自引:0,他引:2
B. Armann M. S. Hanson E. Hatch A. Steffen L. A. Fernandez 《American journal of transplantation》2007,7(1):38-47
We have developed a luminol-based assay using intact islets, which allows for quantification of reactive oxygen species (ROS). In addition, an index capable of characterizing metabolic and mitochondrial integrity prior to transplantation was created based on the capacity of islets to respond to high glucose and rotenone (mitochondrial respiratory chain complex I inhibitor) by production of ROS. To validate this assay, lipid peroxidation and antioxidative defense capacity were evaluated by detection of malondialdehyde (MDA) levels and glutathione peroxidase activity (GPx), respectively. Also, flow cytometric analyses of ROS (dihydroethidine), apoptosis (Annexin V, active caspases), necrosis (Topro3), and mitochondrial membrane potential (JC-1) were done in parallel to correlate with changes in luminol-measured ROS. ATP/ADP ratios were quantified by HPLC and the predictive value of ROS measurement on islet functional potency was correlated with capacity to reverse diabetes in a streptozotocin-induced diabetic NOD.scid mouse model as well as in human transplant recipients. Our data demonstrate that levels of ROS in islets correlate with the percentage of apoptotic cells and their functional potency in vivo. The ROS indices following glucose and rotenone exposure are indicative of metabolic potency and mitochondrial integrity and can be used as surrogate markers to evaluate the quality of islets prior to transplantation. 相似文献
7.
Peter B. Richman MD Shari Dominguez MD David Kasper MD Frederick Chen MD Jeremy Friese MD Joseph Wood MD JD Joseph Collins MD Jeffrey A. Kline MD 《Academic emergency medicine》2006,13(3):295-301
Objectives: To determine interobserver agreement between radiologists for computed tomography (CT) angiography and venography. CT venography of the lower extremities combined with standard CT angiography of the chest may result in an increased overall diagnosis rate of venous thromboembolism (pulmonary embolism or deep venous thrombosis).
Methods: The study had a retrospective cohort design. The population consisted of emergency department patients who were evaluated for suspected pulmonary embolism. A random sample of 50 patients diagnosed and treated for venous thromboembolism and 50 age- and gender-matched patients whose CT angiograms and venograms were read as negative were enrolled. The original reading (R1) was compared with readings of two study radiologists: R2, a general radiologist, and R3, a radiologist with fellowship training in cross-sectional imaging. All readers were blinded to each other.
Results: Both R2 and R3 found both CT angiogram and venogram components technically adequate in 95% (95% CI = 89% to 98%) and 86% (95% CI = 78% to 92%) of studies, respectively. The agreement was very good for CT angiography (lowest agreement = 92%; lowest κ = 0.83) and was good for CT venography (85%, κ = 0.65). In nine cases, R1 read the CT angiogram as negative but the venogram as positive for DVT, whereas both R2 and R3 read both components as negative in four of these nine, suggesting a false-positive isolated DVT rate of 44% (95% CI = 19% to 73%). In no case did R1 read both scan components as negative when R2 and R3 agreed on presence of pulmonary embolism or DVT.
Conclusions: Diagnosis of pulmonary embolism on CT angiography is more reliable than diagnosis of isolated DVT on CT venography. 相似文献
Methods: The study had a retrospective cohort design. The population consisted of emergency department patients who were evaluated for suspected pulmonary embolism. A random sample of 50 patients diagnosed and treated for venous thromboembolism and 50 age- and gender-matched patients whose CT angiograms and venograms were read as negative were enrolled. The original reading (R1) was compared with readings of two study radiologists: R2, a general radiologist, and R3, a radiologist with fellowship training in cross-sectional imaging. All readers were blinded to each other.
Results: Both R2 and R3 found both CT angiogram and venogram components technically adequate in 95% (95% CI = 89% to 98%) and 86% (95% CI = 78% to 92%) of studies, respectively. The agreement was very good for CT angiography (lowest agreement = 92%; lowest κ = 0.83) and was good for CT venography (85%, κ = 0.65). In nine cases, R1 read the CT angiogram as negative but the venogram as positive for DVT, whereas both R2 and R3 read both components as negative in four of these nine, suggesting a false-positive isolated DVT rate of 44% (95% CI = 19% to 73%). In no case did R1 read both scan components as negative when R2 and R3 agreed on presence of pulmonary embolism or DVT.
Conclusions: Diagnosis of pulmonary embolism on CT angiography is more reliable than diagnosis of isolated DVT on CT venography. 相似文献
8.
9.
10.
Joyce J. Fitzpatrick Sheila Ryan DeWitt Baldwin Roger Bulger Jean Johnson-Pawlson Christopher McLaughlin Maureen Kelley Leopold Selketr Bernardine Lacey Charlene Hanson Robin Harvan Patricia Hinton Walker David Sluyter Mary Joan Ladden Neal Vanselow 《Journal of Midwifery & Women's Health》1998,43(1):61-65
In 1995, the National League for Nursing commissioned a Panel on Interdisciplinary/Transdisciplinary Education. The focus of the Panel's work was to examine educational issues that transcend the health professions and to make recommendations for future implementation of an interdisciplinary approach to addressing them. This article is being simultaneously published by several professional journals. The goal is to seek as much feedback as possible. 相似文献