全文获取类型
收费全文 | 1270篇 |
免费 | 91篇 |
国内免费 | 14篇 |
专业分类
耳鼻咽喉 | 24篇 |
儿科学 | 73篇 |
妇产科学 | 27篇 |
基础医学 | 171篇 |
口腔科学 | 33篇 |
临床医学 | 85篇 |
内科学 | 294篇 |
皮肤病学 | 48篇 |
神经病学 | 91篇 |
特种医学 | 155篇 |
外科学 | 115篇 |
综合类 | 22篇 |
预防医学 | 101篇 |
眼科学 | 10篇 |
药学 | 49篇 |
中国医学 | 1篇 |
肿瘤学 | 76篇 |
出版年
2023年 | 9篇 |
2022年 | 10篇 |
2021年 | 27篇 |
2020年 | 13篇 |
2019年 | 24篇 |
2018年 | 29篇 |
2017年 | 25篇 |
2016年 | 23篇 |
2015年 | 33篇 |
2014年 | 27篇 |
2013年 | 46篇 |
2012年 | 65篇 |
2011年 | 62篇 |
2010年 | 58篇 |
2009年 | 46篇 |
2008年 | 51篇 |
2007年 | 56篇 |
2006年 | 49篇 |
2005年 | 58篇 |
2004年 | 73篇 |
2003年 | 39篇 |
2002年 | 37篇 |
2001年 | 55篇 |
2000年 | 36篇 |
1999年 | 16篇 |
1998年 | 28篇 |
1997年 | 41篇 |
1996年 | 26篇 |
1995年 | 23篇 |
1994年 | 20篇 |
1993年 | 9篇 |
1992年 | 18篇 |
1991年 | 6篇 |
1990年 | 15篇 |
1989年 | 19篇 |
1988年 | 19篇 |
1987年 | 26篇 |
1986年 | 16篇 |
1985年 | 13篇 |
1984年 | 11篇 |
1983年 | 14篇 |
1982年 | 7篇 |
1981年 | 11篇 |
1980年 | 15篇 |
1978年 | 7篇 |
1977年 | 9篇 |
1976年 | 9篇 |
1975年 | 7篇 |
1974年 | 7篇 |
1965年 | 6篇 |
排序方式: 共有1375条查询结果,搜索用时 15 毫秒
1.
Bryan E.K. Guevara Suhail Saleem Wan‐Ting Chen Pa‐Fan Hsiao Yu‐Hung Wu 《Journal of cutaneous pathology》2019,46(5):347-352
Lucio phenomenon is an atypical reaction of leprosy, characterized by vasculitic lesions that can mimic antiphospholipid syndrome (APS) clinically. Distinguishing the two can be difficult as antiphospholipid autoantibodies may be present in patients with leprosy. We report on a 32‐year‐old female patient presenting with a sudden onset of fever, hemorrhagic bullae, and skin necrosis on her lower legs. She was treated for APS due to the presence of antiphospholipid antibodies but had an inadequate response. A skin biopsy revealed thrombotic vasculopathy and necrotizing vasculitis associated with aggregation of foam cells in the perivascular area and subcutis, with acid‐fast bacilli in the histiocytes and blood vessel walls. Direct immunofluorescence showed IgM, C3, and fibrinogen deposition in the superficial and deep dermal blood vessels. The pathology confirmed the diagnosis of Lucio phenomenon, and appropriate therapy was given. It is essential to evaluate the patient comprehensively, including clinical, serological, and pathological aspects, to obtain the correct diagnosis. 相似文献
2.
3.
4.
Julieta Ramos-Loyo Andrés Antonio Gonzalez-Garrido Claudia Amezcua Miguel A Guevara 《International journal of psychophysiology》2004,54(3):251-262
In spite of previous reports on the relationship between ongoing EEG and ERPs, there remains a lack of agreement on the nature of their nexuses. The aim of the present study was to evaluate the relationship between resting EEG and the ERP components in two groups of healthy subjects with different levels of performance in a highly demanding selective visual attention task. Young adults were classified according to the amount of their correct responses in the task, into high (HP; averaged hits (AH): 86%) and low performance groups (LP; AH: 59%). EEG was recorded during rest, prior to task performance and absolute (AP) and relative power (RP), as well as inter- (rTER) and intrahemispheric (rTRA) correlation were calculated. ERPs during task performance were also obtained and their amplitude and latency measures were assessed. Results showed that individuals with better behavioral performance had a higher synchronization between both hemispheres during rest as well as higher amplitude and shorter latencies of N2 and P3. Principal Component Analysis revealed that alpha2 AP and RP were inversely related to P2 and N2 latency. Higher values of alpha1 and alpha2 rTER were clustered with higher P3 amplitude and shorter reaction time. In conclusion, the differences in the cortical organization of HP and LP at rest (EEG) seem to be associated to the way the brain reacts during information processing (ERPs). 相似文献
5.
AG Nettetal 《MedR Medizinrecht》2007,25(11):664-666
Abstrakt 1. Nimmt ein Patient einen ihm von seinem (Zahn-)Arzt einger?umten Exklusiv-Termin nicht wahr, obwohl er auf dessen Eigenschaft
ausdrücklich hingewiesen wurde, so hat er dem (Zahn-)Arzt den Behandlungsausfall abzüglich eines angemessenen Eigenanteils
des (Zahn-)Arztes zu ersetzen.
2. Die Ersatzpflicht tritt auch dann ein, wenn der Patient den Termin nicht in der in dem Behandlungsvertrag vorgesehenen
Frist absagt. Eine hierfür seitens des (Zahn-)Arztes bestimmte Frist von zwei Tagen vor Behandlungsbeginn stellt sich für
den Patienten grunds?tzlich auch nicht als unangemessene Benachteiligung i.S. des § 307 BGB dar.
3. Ein Anspruch des Arztes entf?llt auch bei nur mündlicher Vereinbarung nicht unter dem Gesichtspunkt des § 4 Abs. 5b BMV-Z,
denn diese Vorschrift ist teleologisch dahin zu reduzieren, dass nur zahn?rztliche Honoraransprüche aus erfolgten Behandlungen
schriftlich vereinbart werden müssen. Soweit es jedoch um einen vertraglichen Anspruch wegen einer Leistungsst?rung geht,
vermag das Schriftformerfordernis des § 4 Abs. 5b BMV-Z grunds?tzlich nicht einzugreifen. (Leits?tze des Bearbeiters) 相似文献
6.
7.
Early during rat thymus ontogeny, an important proportion of thymocytes
expresses IL-2R and contains IL-2 mRNA. To investigate the role of the
IL-2-IL-2R complex in rat T cell maturation, we supplied either recombinant
rat IL-2 or blocking anti-CD25 mAb to rat fetal thymus organ cultures
(FTOC) under several experimental conditions. The IL-2 treatment initially
stimulated the growth of thymocytes and, as a result, induced T cell
differentiation, but the continuous addition of IL-2 to rat FTOC, as well
as the anti-CD25 administration, resulted in cell number decrease and
inhibition of thymocyte maturation. These results indicate that immature
rat thymocytes bear functional high- affinity IL-2R and that IL-2 promotes
T cell differentiation as a consequence of its capacity to stimulate cell
proliferation. Modifications in TCR alpha beta repertoire and increased
numbers of NKR- P1+ cells, largely NK cells, were also observed in
IL-2-treated FTOC. Furthermore, IL-2-responsiveness of different thymocyte
subsets changed throughout thymic ontogeny. Immature CD4-CD8-cells
responded to IL-2 in two stages, early in thymus development and around
birth, in correlation with the maturation of two distinct waves of thymic
cell progenitors. Mature CD8+ thymocytes maximally responded to IL-2 around
birth, supporting a role for IL-2 in the increased proliferation of mature
thymocytes observed in vivo in the perinatal period. Taken together, these
findings support a role for IL-2 in rat T cell development.
相似文献
8.
Ghosh D; Stewart DR; Nayak NR; Lasley BL; Overstreet JW; Hendrickx AG; Sengupta J 《Human reproduction (Oxford, England)》1997,12(5):914-920
The present study was undertaken to assess the temporal association between
the profiles of serum concentrations of oestradiol-17beta, progesterone,
chorionic gonadotrophin (CG) and relaxin in pregnancies established
naturally, and after embryo transfer, as well as in failed pregnancies in
rhesus monkeys. In naturally mated cycles (group 1) a conception rate of
75% was obtained. In group 1, the mean day of CG detection in serum was
11.5 +/- 1.9 day post-ovulation, and for relaxin, 9.0 +/- 2.5 day
post-ovulation. In group 2, embryo transfer to synchronous, non-mated
surrogate recipients was performed; seven embryo transfer cycles yielded
three pregnancies which were allowed to continue to term and normal infants
were delivered. In embryo transfer cycles the mean day of CG detection was
14.8 +/- 1.8 day post- ovulation, and for relaxin, 11.4 +/- 2.6 day
post-ovulation. A delay of about 3 days was observed in the appearance in
circulation of CG (P < 0.05) and also of relaxin (P < 0.05) between
natural mated and embryo transfer conception cycles. Significant
differences (P < 0.05 for progesterone and P < 0.03 for oestradiol)
were obtained for the areas under the curves for progesterone and
oestradiol between days 12 and 16 in conception cycles compared with failed
pregnancies. These data provide the first observation of the normal
hormonal signals associated with maternal recognition of transferred
embryos during the peri- implantation period, and suggest that the use of
such an experimental primate embryo transfer model may help to elucidate
components of maternal and embryonic signal-response mechanisms during
embryo implantation.
相似文献
9.
A rapid microagglutination test for the diagnosis of Legionella pneumophila (serogroup 1) infection 总被引:4,自引:3,他引:4
下载免费PDF全文
![点击此处可从《Journal of clinical pathology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
A rapid microagglutination test has been developed which can be performed in 30 minutes. Ninety-seven percent of 96 patients diagnosed as having Legionella pneumophila (serogroup 1) infection by indirect immunofluorescence were also detected by the rapid microagglutination test. 相似文献
10.
Chiurillo MA Crisante G Rojas A Peralta A Dias M Guevara P Añez N Ramírez JL 《Clinical and diagnostic laboratory immunology》2003,10(5):775-779
We used the species specificity and repetitious nature of subtelomeric kinetoplastida sequences to generate a duplex PCR assay for the simultaneous detection of Trypanosoma cruzi and Trypanosoma rangeli in experimentally and naturally infected triatomine (Reduviid) bugs and in infected human subjects. The assay was species specific and was capable of detecting 1/20th of T. cruzi and 1/4th of T. rangeli cell equivalents without complementary hybridization. In addition, the PCR-based assay was robust enough for direct application to difficult biological samples such as Reduviid feces or guts and was capable of recognizing all T. cruzi and T. rangeli strains and lineages. Because the assay primers amplify entirely different target sequences, no reaction interference was observed, facilitating future adaptation of this assay to an automated format. 相似文献