全文获取类型
收费全文 | 1624篇 |
免费 | 72篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 51篇 |
妇产科学 | 86篇 |
基础医学 | 73篇 |
口腔科学 | 58篇 |
临床医学 | 136篇 |
内科学 | 405篇 |
皮肤病学 | 11篇 |
神经病学 | 73篇 |
特种医学 | 57篇 |
外科学 | 423篇 |
综合类 | 23篇 |
预防医学 | 35篇 |
眼科学 | 93篇 |
药学 | 61篇 |
肿瘤学 | 113篇 |
出版年
2023年 | 9篇 |
2022年 | 14篇 |
2021年 | 66篇 |
2020年 | 22篇 |
2019年 | 43篇 |
2018年 | 48篇 |
2017年 | 45篇 |
2016年 | 78篇 |
2015年 | 93篇 |
2014年 | 98篇 |
2013年 | 125篇 |
2012年 | 151篇 |
2011年 | 118篇 |
2010年 | 78篇 |
2009年 | 77篇 |
2008年 | 137篇 |
2007年 | 110篇 |
2006年 | 101篇 |
2005年 | 106篇 |
2004年 | 70篇 |
2003年 | 43篇 |
2002年 | 47篇 |
2001年 | 12篇 |
2000年 | 6篇 |
1999年 | 7篇 |
1998年 | 1篇 |
1997年 | 5篇 |
1996年 | 4篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1992年 | 1篇 |
1986年 | 1篇 |
排序方式: 共有1719条查询结果,搜索用时 15 毫秒
1.
Targeting in a cellular level is still one of the major challenges in biomedical treatments. However, new synthetic and analytical techniques now allow the development of precisely prepared macromolecules. Thus, glycopolymer chains are reported to be prepared with controlled length, monomer sequences, as well as chain‐folded structures. A high level of complexity in synthetic macromolecules also allows increased selectivity in targeting, which is a key factor in biomedical applications. 相似文献
2.
Stoma Adjustable Silicone Gastric Banding versus Vertical Banded Gastroplasty for the Treatment of Morbid Obesity 总被引:1,自引:0,他引:1
Background: Among gastric restrictive operations, the procedure of choice is still controversial. The aim of this study is
to compare the results of two different gastric restrictive procedures: vertical banded gastroplasty (VBG) and stoma adjustable
silicone gastric banding (ASGB). Methods: Between 1991 and 1996, 51 patients were treated surgically for morbid obesity: 27
underwent VBG and 24 underwent ASGB. Preoperative body weight (BW), body mass index (BMI) and percentage of ideal body weight
(% IBW) were (mean ± SD): 145.7 ± 45.3 kg; 53.9 ± 15.9 kg/m2; 249.1 ± 73.5% respectively in the VBG group. Corresponding figures for the ASBG group were 132.5 ± 22.7 kg; 46.9 ± 7.8 kg/m2 and 207.2 ± 35.0%. Results: In the VBG group, the median follow-up period was 26 months (range: 7-47). Eighteen months after
the operation BW, BMI, % IBW and percentage of excess weight loss (% EWL) were 85.5 ± 26.8 kg, 31.9 ± 9.8 kg/m2, 145.4 ± 43.9% and 74 ± 1% respectively. Complications included incisional hernia (n = 1), and bowel obstruction (n = 1).
One patient died of acute myocardial infarction on the third postoperative day. In the ASGB group, median follow-up time was
19.7 months (range: 18-26). At 18 months postoperation BW, BMI, % IBW and % EWL values were 86.6 ± 20.6 kg 30.6 ± 6.6 kg/m2
140.6 ± 29.3% and 64 ± 1% respectively. Gastric wall erosion occurred in two patients and the bands had to be removed. These
patients underwent VBG 6 months later. Complications encountered in this group were incisional hernia (n = 1), outlet stenosis
and reflux esophagitis (n = 1), reservoir leakage (n = 1) and gastrointestinal bleeding (n = 1). Two patients died of pulmonary
embolism and acute gastrointestinal bleeding. Conclusions: Weight reduction was not statistically significant between the
two groups. ASGB was easier to perform and less invasive than VBG. 相似文献
3.
Engin Altinta? Dilek O?uz Sabite Ka?ar Yasemin Ozderin Orhan Sezgin Neslihan Inci Zengin 《The Turkish journal of gastroenterology》2004,15(1):49-52
Dydrogesterone, similar to women's natural progesterone, has been used in a wide range of gynecological conditions. Despite its widespread use, dydrogesterone-induced hepatotoxicity and dydrogesterone-induced hemolytic anemia have, to the best of our knowledge, never been reported previously. We describe a case of hepatitis and warm antibody hemolytic anemia due to dydrogesterone. 相似文献
4.
Lipid peroxidation, erythrocyte superoxide-dismutase activity and trace metals in young male footballers 总被引:6,自引:0,他引:6
Metin G Atukeren P Alturfan AA Gulyasar T Kaya M Gumustas MK 《Yonsei medical journal》2003,44(6):979-986
Physical training is known to induce oxidative stress in individuals subjected to intense exercise. In this study, we investigated plasma malondialdehyde (MDA) levels and erythrocyte superoxide dismutase (SOD) activity of 25 young male footballers and a control group of similar age. Red blood cell (RBC) count, haemoglobin (Hb) and haematocrit (Hct) values, and copper (Cu) and zinc (Zn) levels were also examined. The maximal oxygen uptake (VO2max) of all subjects was determined in order to establish their functional capacity. The main finding of the present study was that plasma MDA levels, one of the most commonly used markers of lipid peroxidation, of this group of footballers aged under 21 decreased slightly when compared with those of the control group (p < 0.001). In contrast, erythrocyte SOD activity was higher in the footballer group than in the controls (p < 0.001). Footballers who are under regular training showed an improved antioxidant activity in comparison to sedentary controls. Plasma copper concentration, RBC count and Hb concentration of the footballer group were all significantly lower than those of the control group, (p < 0.001, p < 0.01, p < 0.01, respectively). Investigating the footballers' data with Spearman's correlation analyses, the correlation coefficients (r) between Zn/Cu ratio and SOD was positive (r=0.44; p < 0.05); and between VO2max and SOD (r=0.42; p < 0.05) were both positive. On the basis of statistical analysis, we suggest that regular exercise may be beneficial in cases of oxidative damage by reducing the amount of lipid peroxidation and increasing the activity of the antioxidant enzyme SOD. 相似文献
5.
Alexandra P. Key Hatun Zengin‐Bolatkale Anastasia Dimitropoulos Ellen Doernberg 《American journal of medical genetics. Part A》2020,182(7):1655-1663
This study examined sensitivity of eye tracking measures to hyperphagia severity in Prader‐Willi syndrome (PWS). Gaze data were collected in 57 children with PWS, age 3–11 years, and 47 typically developing peers at two study sites during free visual exploration of complex stimulus arrays that included images of food, animals, and household objects. Analysis of the number and duration of fixations as well as gaze perseverations revealed that food items are not exceptionally salient for children with PWS. Instead, increased attention to food in the context of other high‐interest items (e.g., animals) was associated with caregiver reports of more severe hyperphagia and more advanced nutritional phase. The study also provided preliminary evidence of possible genetic subtype and sex differences as well as demonstrated that multiple investigators in a wide range of settings can effectively implement the eye tracking protocol. The results indicate that gaze characteristics derived from eye tracking may be a promising objective marker of hyperphagia in PWS for use in research and clinical trials. 相似文献
6.
Mustafa Sacar Gokhan Onem Ahmet Baltalarli Suzan Sacar Huseyin Turgut Ibrahim Goksin Vefa Ozcan Serhan Sakarya 《Journal of artificial organs》2007,10(3):177-180
Because slime-forming microorganisms are the major causative agents of graft infections, we aimed to investigate bacterial
adherence in slime-forming and nonslime-forming Staphylococcus aureus and to determine the role of neuraminidase (NANase) on adherence to gelatin-impregnated polyester fiber graft fabric. An
in vitro model was developed to quantitatively measure bacterial adherence to the surface of the graft. The grafts were divided
into two groups – those colonized with slime-forming S. aureus and those colonized with nonslime-forming S. aureus. The grafts were put into sterile tubes and human plasma was instilled and incubated at 37°C to perform fibrin deposition
on the grafts. After 48 h of incubation, grafts were drained and inoculated with slime-forming or nonslime-forming S. aureus in triptic soy broth in the presence or absence of NANase. Following 36 h of incubation at 36°C, grafts were vortexed and
cultured to perform a colony count. Bacterial counts were expressed as total colony-forming units per square centimeter of
graft. Slime-forming S. aureus had greater affinity with the graft compared with nonslime-forming S. aureus (P < 0.05). The adherence of slime-forming S. aureus was impaired by NANase treatment (P < 0.001) but NANase treatment of nonslime-forming S. aureus did not change the adherence to the graft (P > 0.05). These results show that slime plays an important role in the pathogenesis of vascular graft infection. Adherence
of slime-forming S. aureus can be decreased by NANase treatment. This may have implications for the development of neuraminidase-embedded vascular grafts
to diminish biomaterial-related infections. 相似文献
7.
Yamac D Celenkoglu G Coskun U Akyurek N Akcali Z Dursun A Koybasioglu F 《Pathology, research and practice》2005,201(7):497-502
A relationship between cyclooxygenase-2 (COX-2) expression and the pathogenesis of colorectal cancer has been reported in recent studies. Moreover, it has been indicated that COX-2 expression may have a prognostic role in colorectal cancer patients. In this study, we investigated the prognostic significance of COX-2 expression in 83 patients with colorectal cancer. COX-2 expression was assessed using immunohistochemical methods and was evaluated by grading both staining intensity and staining extension. The relationships between COX-2 expression and clinicopathological features of the patients and patient survival were evaluated. There was no relationships between COX-2 expression and tumor size (tm < 3 cm or tm > or = 3 cm), tumor histopathological differentiation (poorly differentiated or moderately + well differentiated), number of metastatic lymph nodes (< 4 or 3 > or = 4), histopathology of the tumor, localization of the tumor (colon or rectum), distant metastasis, and vascular invasion of the tumor. In the multivariate analysis, COX-2 expression was not found as an independent prognostic factor. We demonstrated that COX-2 expression was not correlated with clinicopathological characteristics of colon carcinoma and disease outcome. 相似文献
8.
Tahir
ztürk Mehmet Burta Eren aatay Zengin Orhan Balta Mete Gedikba Frat Erpala 《Indian Journal of Orthopaedics》2021,55(2):471
PurposeThis study aimed to evaluate the effects of not using a drain or placing a drain in the glenohumeral (GH) or subacromial (SA) joint spaces on fluid retention and pain in the early postoperative period and late clinical outcomes.MethodsPatients who underwent arthroscopic rotator cuff repair between 2018 and 2020 were included in the study. Before the operation, demographic data, range of motion (ROM), visual analog scale (VAS) scores, Constant–Murley scores has documented. Deltoid muscle diameter (DMD) were measured. The total amount of irrigation used during the surgery and the operation duration were recorded, and the active amount of fluid coming from the drain in patients with a drain was recorded. The first postoperative DMD measure was made in the operating room and accepted as day 0. DMD measurements repeated postoperative first and second day. VAS assessments were performed on the postoperative first and second days. At the outpatient clinic, these measurements were repeated on the first and second weeks after discharge. Functional evaluations were made with ROM and Constant–Murley scores at the final follow-up examination.ResultsThere was no difference in the amount of drainage between the two groups in which a drain was used. When the three groups were compared among themselves regarding preoperative and postoperative VAS scores, Constant–Murley scores, and DMD, no significant difference was found.ConclusionsWe do not recommend the routine use of drains after arthroscopic rotator cuff surgery in terms of cost-effectiveness.Level of evidenceLevel II: Prospective Cohort Study. 相似文献
9.
Ugur Selek Mustafa Cengiz Gokhan Ozyigit Ferah Yildiz Ibtisam Lale Atahan 《Radiotherapy and oncology》2005,76(1):107-8; author reply 108
10.
Suleyman Ercan M.D. Gokhan Gokaslan M.D. Vedat Davutoglu M.D. Ibrahim Halil Inanc M.D. Vuslat Bosnak M.D. Hayati Deniz M.D. 《Echocardiography (Mount Kisco, N.Y.)》2013,30(8):E236-E238
Herein, we present a case of asymptomatic isolated cardiac cystic echinococcosis localized entirely to the inter‐atrial septum in a pregnant woman. The patient underwent successful surgery. Cardiac cystic echinococcosis is rarely seen in pregnancy. A high index of suspicion is necessary for the diagnosis of a cardiac cyst hydatid. The treatment of cardiac cyst hydatid is surgical and should not be delayed during pregnancy. Early surgery might prevent septic embolization and cardiac life‐threatening complications and save the lives of both mother and baby as in the present case. 相似文献